Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gdpd3provided by MGI
Official Full Name: glycerophosphodiester phosphodiesterase domain containing 3provided by MGI
Primary source: MGI:MGI:1915866
See related: Ensembl:ENSMUSG00000030703 AllianceGenome:MGI:1915866
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110015E22Rik
Summary: Enables lysophospholipase activity and phosphoric diester hydrolase activity. Involved in N-acylethanolamine metabolic process and phosphatidylcholine catabolic process. Located in endoplasmic reticulum membrane and perinuclear region of cytoplasm. Orthologous to human GDPD3 (glycerophosphodiester phosphodiesterase domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 24.7), kidney adult (RPKM 15.0) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.25 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126365586..126374817)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (126766414..126775645)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GDPD3 Deficiency Alleviates Neuropathic Pain and Reprograms Macrophagic Polarization Through PGE2 and PPARgamma Pathway.
Title: GDPD3 Deficiency Alleviates Neuropathic Pain and Reprograms Macrophagic Polarization Through PGE2 and PPARγ Pathway.
Characterization of recombinant murine GDE4 and GDE7, enzymes producing lysophosphatidic acid and/or cyclic phosphatidic acid.
Title: Characterization of recombinant murine GDE4 and GDE7, enzymes producing lysophosphatidic acid and/or cyclic phosphatidic acid.
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Title: The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
this study identified Gdpd3 as a candidate genetic marker for memory T cells
Title: CD4 memory T cells develop and acquire functional competence by sequential cognate interactions and stepwise gene regulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3) 1 citation

General gene information

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Markers

Prkm3-rs1 (e-PCR), detects polymorphism
- UniSTS:144262

Mapk3 (e-PCR), detects polymorphism
- UniSTS:143826

Mapk3 (e-PCR), detects polymorphism
- UniSTS:143827

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lysophospholipase activity	EXP Inferred from Experiment more info	PubMed
enables lysophospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoric diester hydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphoric diester hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-acylethanolamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in N-acylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerophospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lysophospholipase D GDPD3

Names: glycerophosphodiester phosphodiesterase 7; glycerophosphodiester phosphodiesterase domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024228.2 → NP_077190.2 lysophospholipase D GDPD3

See identical proteins and their annotated locations for NP_077190.2

Status: VALIDATED

Source sequence(s)

AK003726, AW045753, BY101331

Consensus CDS

CCDS40130.1

UniProtKB/Swiss-Prot

Q99LY2, Q9D1C0

Related

ENSMUSP00000032944.8, ENSMUST00000032944.9

Conserved Domains (2) summary

cd08612
Location:13 → 310

GDPD_GDE4; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE4 and similar proteins

COG0584
Location:34 → 311

UgpQ; Glycerophosphoryl diester phosphodiesterase [Lipid transport and metabolism]