Pde3a phosphodiesterase 3A, cGMP inhibited [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pde3aprovided by MGI
Official Full Name: phosphodiesterase 3A, cGMP inhibitedprovided by MGI
Primary source: MGI:MGI:1860764
See related: Ensembl:ENSMUSG00000041741 AllianceGenome:MGI:1860764
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A930022O17Rik
Summary: Enables 3',5'-cyclic-AMP phosphodiesterase activity. Acts upstream of or within several processes, including oocyte maturation; positive regulation of oocyte development; and regulation of meiotic nuclear division. Located in cytosol and membrane. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 3.5), heart adult (RPKM 3.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G2; 6 71.87 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (141194995..141452588)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (141249269..141506862)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism.
Title: Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism.
Nitration of protein kinase G-Ialpha modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury.
Title: Nitration of protein kinase G-Iα modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury.
Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure.
Title: Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure.
High PDE3A expression is associated with adverse cardiac remodeling.
Title: Phosphodiesterase type 3A (PDE3A), but not type 3B (PDE3B), contributes to the adverse cardiac remodeling induced by pressure overload.
Study demonstrated the presence of PDE3 protein and mRNA in human and murine airway tissues and concluded that PDE3A or PDE3B deficiency or pharmacological inhibition of PDE3 may alleviate the symptoms of allergic airway inflammation in a house dust mite-driven allergic airway inflammation mouse model.
Title: A pathophysiological role of PDE3 in allergic airway inflammation.
NO-GC modulates PDE3A expression.
Title: Phosphodiesterase 3A expression and activity in the murine vasculature is influenced by NO-sensitive guanylyl cyclase.
Data show that phosphodiesterase 3A (PDE3A) was expressed throughout interstitial cells of Cajal (ICC) development and that ICC density was halved in PDE3A-deficient mice.
Title: Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST).
PDE3A is a low-affinity and high-velocity enzyme for hydrolysis of cUMP in cardiac myocytes.
Title: cUMP hydrolysis by PDE3A.
These together indicate that PDE3A1 negatively regulates beta-AR signaling and protects against I/R injury by inhibiting cardiomyocyte apoptosis.
Title: Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury.
PDE3A is the primary isozyme modulating basal myocardial contractility and sarcoplasmic reticulum divalent calcium ion (Ca2+) content.
Title: Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heart.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

31.MMHAP63FLC4.seq (e-PCR)
- UniSTS:123949

NoName (e-PCR)
- UniSTS:235570

BB361933 (e-PCR)
- UniSTS:208045

Pde3a (e-PCR), detects polymorphism
- UniSTS:507121

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3',5'-cyclic-AMP phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables estrogen binding	ISO Inferred from Sequence Orthology more info
enables estrogen binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cGMP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cGMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cAMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular permeability	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of oocyte development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within oocyte maturation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of oocyte development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of vascular permeability	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of meiotic nuclear division	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of ribonuclease activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of ribonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

Names: CGI-PDE A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cGMP-inhibited phosphodiesterase; cyclic GMP-inhibited phosphodiesterase A

NP_061249.1

EC 3.1.4.17

XP_006507042.1

EC 3.1.4.17

XP_011239897.1

EC 3.1.4.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018779.2 → NP_061249.1 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

See identical proteins and their annotated locations for NP_061249.1

Status: VALIDATED

Source sequence(s)

AC155835, AF099187

Consensus CDS

CCDS20676.1

UniProtKB/Swiss-Prot

Q9Z0X4

UniProtKB/TrEMBL

B2RR84

Related

ENSMUSP00000038749.8, ENSMUST00000043259.10

Conserved Domains (1) summary

pfam00233
Location:751 → 1012

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

141194995..141452588

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506979.5 → XP_006507042.1 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X2

Conserved Domains (1) summary

pfam00233
Location:451 → 712

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_011241595.4 → XP_011239897.1 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1

Conserved Domains (1) summary

pfam00233
Location:456 → 717

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase