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    ATP6V0A1 ATPase H+ transporting V0 subunit a1 [ Homo sapiens (human) ]

    Gene ID: 535, updated on 9-Jun-2024

    Summary

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    Official Symbol
    ATP6V0A1provided by HGNC
    Official Full Name
    ATPase H+ transporting V0 subunit a1provided by HGNC
    Primary source
    HGNC:HGNC:865
    See related
    Ensembl:ENSG00000033627 MIM:192130; AllianceGenome:HGNC:865
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    a1; Stv1; VPP1; Vph1; ATP6N1; DEE104; NEDEBA; ATP6N1A
    Summary
    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 46.5), kidney (RPKM 12.3) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ATP6V0A1 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42458878..42522579)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43316076..43379766)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40610896..40674597)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12200 Neighboring gene caveolae associated protein 1 Neighboring gene uncharacterized LOC102725238 Neighboring gene RNA, U7 small nuclear 97 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8529 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8530 Neighboring gene microRNA 548at Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40668625-40669124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8531 Neighboring gene microRNA 5010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8533 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40688565-40689302 Neighboring gene PTP4A2 pseudogene 1 Neighboring gene N-acetyl-alpha-glucosaminidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. V-ATPase V0a1 promotes Weibel-Palade body biogenesis through the regulation of membrane fission. Yamazaki Y, et al. Elife, 2021 Dec 14. PMID 34904569, Free PMC Article
    2. Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum. Hsin IL, et al. Br J Pharmacol, 2012 Nov. PMID 22708544, Free PMC Article
    3. Vacuolar H(+)-ATPase mutants transform cells and define a binding site for the papillomavirus E5 oncoprotein. Andresson T, et al. J Biol Chem, 1995 Mar 24. PMID 7896830
    4. ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice. Aoto K, et al. Nat Commun, 2021 Apr 8. PMID 33833240, Free PMC Article
    5. Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer. Brisson L, et al. Cancer Cell, 2016 Sep 12. PMID 27622334

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. V-ATPase V0a1 promotes Weibel-Palade body biogenesis through the regulation of membrane fission.
      Title: V-ATPase V0a1 promotes Weibel-Palade body biogenesis through the regulation of membrane fission.
    2. ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice.
      Title: ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice.
    3. The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells.
      Title: The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells.
    4. Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum. ATP6V0A1 plays an important role in mediating autophagosome-lysosome fusion.
      Title: Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum.
    5. a series of events whereby ATP6V0A1 3'-UTR variant T+3246C functioned: ATP6V0A1 expression probably was affected through differential micro-RNA effects, altering vacuolar pH and consequently CHGA processing and exocytotic secretion.
      Title: A common genetic variant in the 3'-UTR of vacuolar H+-ATPase ATP6V0A1 creates a micro-RNA motif to alter chromogranin A processing and hypertension risk.
    6. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
    7. The mRNA levels of POLR2F, ATP6V0A1 and PRNP were evaluated by quantitative RT-PCR in 70 colorectal carcinomas and 17 normal tissue specimens and were correlated with clinicopathological parameters.
      Title: POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Developmental and epileptic encephalopathy 104
    MedGen: C5774183 OMIM: 619970 GeneReviews: Not available
    		not available
    Neurodevelopmental disorder with epilepsy and brain atrophy
    MedGen: C5774184 OMIM: 619971 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of ATPase, H+ transporting, lysosomal V0 subunit a1 (ATP6V0A1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp781J1951

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosomal lumen acidification NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in lysosomal lumen acidification NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proton transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle lumen acidification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar acidification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in endosome membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in lysosomal membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of proton-transporting V-type ATPase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase 116 kDa subunit a 1
    Names
    ATPase, H+ transporting, lysosomal V0 subunit a1
    ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD)
    H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1
    V-ATPase 116 kDa subunit a 1
    V-ATPase 116 kDa subunit a1
    V-ATPase subunit a1
    V-type proton ATPase 116 kDa subunit a
    V-type proton ATPase 116 kDa subunit a1
    clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit
    vacuolar adenosine triphosphatase subunit Ac116
    vacuolar proton pump subunit 1
    vacuolar proton translocating ATPase 116 kDa subunit A
    vacuolar-type H(+)-ATPase 115 kDa subunit
    NP_001123492.1
    NP_001123493.1
    NP_001365451.1
    NP_001365452.1
    NP_001365459.1
    NP_001365460.1
    NP_001365461.1
    NP_001365462.1
    NP_001365463.1
    NP_001365464.1
    NP_001365465.1
    NP_001365466.1
    NP_001365467.1
    NP_001365468.1
    NP_001365469.1
    NP_001365470.1
    NP_001365471.1
    NP_001365472.1
    NP_001365473.1
    NP_001365474.1
    NP_001365475.1
    NP_001365476.1
    NP_001365477.1
    NP_001365478.1
    NP_001365479.1
    NP_001365480.1
    NP_001365481.1
    NP_001365483.1
    NP_001365485.1
    NP_001365486.1
    NP_005168.2
    XP_047292260.1
    XP_047292261.1
    XP_054172489.1
    XP_054172490.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047037.1 RefSeqGene

      Range
      5035..68736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130020.3 → NP_001123492.1  V-type proton ATPase 116 kDa subunit a 1 isoform 2

      See identical proteins and their annotated locations for NP_001123492.1

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      Consensus CDS
      CCDS45683.1
      UniProtKB/TrEMBL
      Q5CZH6
      Related
      ENSP00000264649.5, ENST00000264649.10
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 828
      V_ATPase_I; V-type ATPase 116kDa subunit family

    2. NM_001130021.3 → NP_001123493.1  V-type proton ATPase 116 kDa subunit a 1 isoform 1

      See identical proteins and their annotated locations for NP_001123493.1

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      Consensus CDS
      CCDS45684.1
      UniProtKB/Swiss-Prot
      B7Z3B7, Q8N5G7, Q93050, Q9NSX0
      UniProtKB/TrEMBL
      Q53ET5
      Related
      ENSP00000342951.3, ENST00000343619.9
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 827
      V_ATPase_I; V-type ATPase 116kDa subunit family

    3. NM_001378522.1 → NP_001365451.1  V-type proton ATPase 116 kDa subunit a 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      Q5CZH6
      Related
      ENSP00000515529.1, ENST00000703892.1
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 834
      V_ATPase_I; V-type ATPase 116kDa subunit family

    4. NM_001378523.1 → NP_001365452.1  V-type proton ATPase 116 kDa subunit a 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      Q5CZH6
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 792
      V_ATPase_I; V-type ATPase 116kDa subunit family

    5. NM_001378530.1 → NP_001365459.1  V-type proton ATPase 116 kDa subunit a 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      Q53ET5
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 893
      V_ATPase_I; V-type ATPase 116kDa subunit family

    6. NM_001378531.1 → NP_001365460.1  V-type proton ATPase 116 kDa subunit a 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      Q5CZH6
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 875
      V_ATPase_I; V-type ATPase 116kDa subunit family

    7. NM_001378532.1 → NP_001365461.1  V-type proton ATPase 116 kDa subunit a 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      Consensus CDS
      CCDS92317.1
      UniProtKB/TrEMBL
      A0A994J3Z0, Q5CZH6
      Related
      ENSP00000515525.1, ENST00000703888.1
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 869
      V_ATPase_I; V-type ATPase 116kDa subunit family

    8. NM_001378533.1 → NP_001365462.1  V-type proton ATPase 116 kDa subunit a 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      Consensus CDS
      CCDS92318.1
      UniProtKB/TrEMBL
      K7EN36, Q53ET5
      Related
      ENSP00000466767.2, ENST00000592324.2
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 868
      V_ATPase_I; V-type ATPase 116kDa subunit family

    9. NM_001378534.1 → NP_001365463.1  V-type proton ATPase 116 kDa subunit a 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      Q5CZH6
      Related
      ENSP00000515531.1, ENST00000703894.1
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 859
      V_ATPase_I; V-type ATPase 116kDa subunit family

    10. NM_001378535.1 → NP_001365464.1  V-type proton ATPase 116 kDa subunit a 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      Consensus CDS
      CCDS92319.1
      UniProtKB/TrEMBL
      K7ENA1, Q53ET5
      Related
      ENSP00000466852.2, ENST00000588138.2
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 852
      V_ATPase_I; V-type ATPase 116kDa subunit family

    11. NM_001378536.1 → NP_001365465.1  V-type proton ATPase 116 kDa subunit a 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      Consensus CDS
      CCDS92322.1
      UniProtKB/TrEMBL
      A0A994J3Z4, A0A994J473
      Related
      ENSP00000515530.1, ENST00000703893.1
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 791
      V_ATPase_I; V-type ATPase 116kDa subunit family

    12. NM_001378537.1 → NP_001365466.1  V-type proton ATPase 116 kDa subunit a 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      Q53ET5
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 785
      V_ATPase_I; V-type ATPase 116kDa subunit family

    13. NM_001378538.1 → NP_001365467.1  V-type proton ATPase 116 kDa subunit a 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      Consensus CDS
      CCDS92323.1
      UniProtKB/TrEMBL
      A0A994J473, B7Z2A9
      Related
      ENSP00000466878.1, ENST00000585525.5
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 784
      V_ATPase_I; V-type ATPase 116kDa subunit family

    14. NM_001378539.1 → NP_001365468.1  V-type proton ATPase 116 kDa subunit a 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      A0A994J6N0
      Related
      ENSP00000515526.1, ENST00000703889.1
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 760
      V_ATPase_I; V-type ATPase 116kDa subunit family

    15. NM_001378540.1 → NP_001365469.1  V-type proton ATPase 116 kDa subunit a 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      Consensus CDS
      CCDS92324.1
      UniProtKB/TrEMBL
      A0A994J473, B7Z641
      Related
      ENSP00000443991.1, ENST00000537728.5
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 778
      V_ATPase_I; V-type ATPase 116kDa subunit family

    16. NM_001378541.1 → NP_001365470.1  V-type proton ATPase 116 kDa subunit a 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      A0A994J6N0
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 754
      V_ATPase_I; V-type ATPase 116kDa subunit family

    17. NM_001378542.1 → NP_001365471.1  V-type proton ATPase 116 kDa subunit a 1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      Consensus CDS
      CCDS92320.1
      UniProtKB/TrEMBL
      A0A994J4L9, K7ERA6
      Related
      ENSP00000468177.2, ENST00000586201.6
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 753
      V_ATPase_I; V-type ATPase 116kDa subunit family

    18. NM_001378543.1 → NP_001365472.1  V-type proton ATPase 116 kDa subunit a 1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      Q5CZH6
      Conserved Domains (1) summary
      pfam01496
      Location:1 → 768
      V_ATPase_I; V-type ATPase 116kDa subunit family

    19. NM_001378544.1 → NP_001365473.1  V-type proton ATPase 116 kDa subunit a 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      A0A994J4L9
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 747
      V_ATPase_I; V-type ATPase 116kDa subunit family

    20. NM_001378545.1 → NP_001365474.1  V-type proton ATPase 116 kDa subunit a 1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      Consensus CDS
      CCDS92321.1
      UniProtKB/TrEMBL
      A0A994J3Z9, A0A994J473
      Related
      ENSP00000515535.1, ENST00000703897.1
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 757
      V_ATPase_I; V-type ATPase 116kDa subunit family

    21. NM_001378546.1 → NP_001365475.1  V-type proton ATPase 116 kDa subunit a 1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      Q53ET5
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 756
      V_ATPase_I; V-type ATPase 116kDa subunit family

    22. NM_001378547.1 → NP_001365476.1  V-type proton ATPase 116 kDa subunit a 1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      Q53ET5
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 750
      V_ATPase_I; V-type ATPase 116kDa subunit family

    23. NM_001378548.1 → NP_001365477.1  V-type proton ATPase 116 kDa subunit a 1 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      Q53ET5
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 745
      V_ATPase_I; V-type ATPase 116kDa subunit family

    24. NM_001378549.1 → NP_001365478.1  V-type proton ATPase 116 kDa subunit a 1 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      Q53ET5
      Conserved Domains (1) summary
      pfam01496
      Location:1 → 767
      V_ATPase_I; V-type ATPase 116kDa subunit family

    25. NM_001378550.1 → NP_001365479.1  V-type proton ATPase 116 kDa subunit a 1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      A0A994J473
      Conserved Domains (1) summary
      pfam01496
      Location:28 → 785
      V_ATPase_I; V-type ATPase 116kDa subunit family

    26. NM_001378551.1 → NP_001365480.1  V-type proton ATPase 116 kDa subunit a 1 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      Q53ET5
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 862
      V_ATPase_I; V-type ATPase 116kDa subunit family

    27. NM_001378552.1 → NP_001365481.1  V-type proton ATPase 116 kDa subunit a 1 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      A0A994J4L9
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 788
      V_ATPase_I; V-type ATPase 116kDa subunit family

    28. NM_001378554.1 → NP_001365483.1  V-type proton ATPase 116 kDa subunit a 1 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      Q53ET5
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 751
      V_ATPase_I; V-type ATPase 116kDa subunit family

    29. NM_001378556.1 → NP_001365485.1  V-type proton ATPase 116 kDa subunit a 1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      A0A994J4L9
      Conserved Domains (1) summary
      pfam01496
      Location:28 → 711
      V_ATPase_I; V-type ATPase 116kDa subunit family

    30. NM_001378557.1 → NP_001365486.1  V-type proton ATPase 116 kDa subunit a 1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      UniProtKB/TrEMBL
      A0A994J4L9
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 711
      V_ATPase_I; V-type ATPase 116kDa subunit family

    31. NM_005177.5 → NP_005168.2  V-type proton ATPase 116 kDa subunit a 1 isoform 3

      See identical proteins and their annotated locations for NP_005168.2

      Status: REVIEWED

      Source sequence(s)
      AC067852, AC107993
      Consensus CDS
      CCDS11426.1
      UniProtKB/TrEMBL
      Q53ET5
      Related
      ENSP00000377415.2, ENST00000393829.6
      Conserved Domains (1) summary
      pfam01496
      Location:27 → 821
      V_ATPase_I; V-type ATPase 116kDa subunit family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      42458878..42522579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436305.1 → XP_047292261.1  V-type proton ATPase 116 kDa subunit a 1 isoform X2

      UniProtKB/TrEMBL
      A0A994J6N0

    2. XM_047436304.1 → XP_047292260.1  V-type proton ATPase 116 kDa subunit a 1 isoform X1

      UniProtKB/TrEMBL
      A0A994J728

    RNA

    1. XR_007065303.1 RNA Sequence

    2. XR_007065304.1 RNA Sequence

    3. XR_007065306.1 RNA Sequence

    4. XR_007065305.1 RNA Sequence

    5. XR_007065307.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      43316076..43379766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316515.1 → XP_054172490.1  V-type proton ATPase 116 kDa subunit a 1 isoform X2

      UniProtKB/TrEMBL
      A0A994J6N0

    2. XM_054316514.1 → XP_054172489.1  V-type proton ATPase 116 kDa subunit a 1 isoform X1

      UniProtKB/TrEMBL
      A0A994J728

    RNA

    1. XR_008484834.1 RNA Sequence

    2. XR_008484835.1 RNA Sequence

    3. XR_008484837.1 RNA Sequence

    4. XR_008484836.1 RNA Sequence

    5. XR_008484838.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93050.3 GenPept UniProtKB/Swiss-Prot:Q93050

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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