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    COS8 Cos8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856337, updated on 17-May-2024

    Summary

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    Gene symbol
    COS8
    Gene description
    Cos8p
    Primary source
    FungiDB:YHL048W
    Locus tag
    YHL048W
    See related
    SGD:S000001040; AllianceGenome:SGD:S000001040; VEuPathDB:YHL048W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See COS8 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (6401..7546)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene siderophore transporter Neighboring gene seripauperin PAU13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Finding undetected protein associations in cell signaling by belief propagation. Bailly-Bechet M, et al. Proc Natl Acad Sci U S A, 2011 Jan 11. PMID 21187432, Free PMC Article
    2. ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes. Spode I, et al. J Mol Biol, 2002 May 31. PMID 12051917
    3. An evolutionary scenario for one of the largest yeast gene families. Despons L, et al. Trends Genet, 2006 Jan. PMID 16269202
    4. ATP-binding cassette transporters and sterol O-acyltransferases interact at membrane microdomains to modulate sterol uptake and esterification. Gulati S, et al. FASEB J, 2015 Nov. PMID 26220175, Free PMC Article
    5. A family of tetraspans organizes cargo for sorting into multivesicular bodies. MacDonald C, et al. Dev Cell, 2015 May 4. PMID 25942624, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cos8p
    NP_011815.1
    • Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      6401..7546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179128.1 → NP_011815.1  TPA: Cos8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011815.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKS3, P38723
      UniProtKB/TrEMBL
      A0A8H4C1W3
      Conserved Domains (1) summary
      pfam00674
      Location:261 → 353
      DUP; DUP family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38723.1

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