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    Catip ciliogenesis associated TTC17 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 241112, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Catipprovided by MGI
    Official Full Name
    ciliogenesis associated TTC17 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:2685062
    See related
    Ensembl:ENSMUSG00000073650 AllianceGenome:MGI:2685062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm216
    Summary
    Predicted to be involved in actin filament polymerization and cilium organization. Predicted to be located in several cellular components, including actin cytoskeleton; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in spermatogenic failure 54. Orthologous to human CATIP (ciliogenesis associated TTC17 interacting protein). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in testis adult (RPKM 7.0), lung adult (RPKM 3.0) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Catip in Genome Data Viewer
    Location:
    1 C3; 1 38.54 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74401272..74408482)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74362113..74369323)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E175 Neighboring gene predicted gene 28364 Neighboring gene angio-associated migratory protein Neighboring gene paroxysmal nonkinesiogenic dyskinesia Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3281 Neighboring gene STARR-positive B cell enhancer ABC_E4323 Neighboring gene STARR-seq mESC enhancer starr_01333 Neighboring gene solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:74433475-74433675 Neighboring gene STARR-positive B cell enhancer ABC_E2549 Neighboring gene CTD small phosphatase 1 Neighboring gene predicted gene, 53562 Neighboring gene microRNA 26b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cilium organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ciliogenesis-associated TTC17-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379457.1 → NP_001366386.1  ciliogenesis-associated TTC17-interacting protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AC098570
      Consensus CDS
      CCDS15046.1
      UniProtKB/TrEMBL
      A0A8V5KY96, F7AAT1
      Related
      ENSMUSP00000117442.3, ENSMUST00000128445.9

    RNA

    1. NR_166731.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC098570
      Related
      ENSMUST00000097697.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      74401272..74408482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238521.1 → XP_011236823.1  ciliogenesis-associated TTC17-interacting protein isoform X1

      UniProtKB/TrEMBL
      A0A8V5KY96

    2. XM_017320632.1 → XP_017176121.1  ciliogenesis-associated TTC17-interacting protein isoform X2

      UniProtKB/Swiss-Prot
      B9EKE5, Q3UUR2
      UniProtKB/TrEMBL
      A0A8V5KY96
      Related
      ENSMUST00000191010.2
      Conserved Domains (1) summary
      cl02594
      Location:303 → 342
      DD_R_PKA_DPY30-like; dimerization/docking (D/D) domains found in the cAMP-dependent protein kinase regulatory subunit (PRKAR) and the DPY30/SDC1-like family

    3. XM_011238522.2 → XP_011236824.1  ciliogenesis-associated TTC17-interacting protein isoform X3

    4. XM_017320639.2 → XP_017176128.1  ciliogenesis-associated TTC17-interacting protein isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B9EKE5.1 GenPept UniProtKB/Swiss-Prot:B9EKE5

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