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    Trim63 tripartite motif-containing 63 [ Mus musculus (house mouse) ]

    Gene ID: 433766, updated on 2-Nov-2024

    Summary

    Official Symbol
    Trim63provided by MGI
    Official Full Name
    tripartite motif-containing 63provided by MGI
    Primary source
    MGI:MGI:2447992
    See related
    Ensembl:ENSMUSG00000028834 AllianceGenome:MGI:2447992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RF1; MuRF1; Rnf28
    Summary
    Enables ubiquitin protein ligase activity. Involved in protein monoubiquitination and response to denervation involved in regulation of muscle adaptation. Acts upstream of or within several processes, including cellular response to dexamethasone stimulus; myotube cell development; and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in embryo and heart. Orthologous to human TRIM63 (tripartite motif containing 63). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 54.2) and mammary gland adult (RPKM 5.3) See more
    Orthologs
    NEW
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    Genomic context

    See Trim63 in Genome Data Viewer
    Location:
    4 D2.3; 4 66.58 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134042431..134056940)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134315120..134329629)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 110, member D Neighboring gene predicted gene, 42325 Neighboring gene STARR-positive B cell enhancer ABC_E4679 Neighboring gene PDLIM1 interacting kinase 1 like Neighboring gene STARR-seq mESC enhancer starr_11671 Neighboring gene solute carrier family 30 (zinc transporter), member 2 Neighboring gene exostosin-like glycosyltransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables titin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in M band IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in contractile muscle fiber ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM63
    Names
    MURF-1
    RING-type E3 ubiquitin transferase TRIM63
    muscle ring finger protein 1
    muscle-specific RING finger protein 1
    ring finger protein 28
    tripartite motif-containing protein 63
    NP_001034137.2
    NP_001356174.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039048.2NP_001034137.2  E3 ubiquitin-protein ligase TRIM63 isoform 1

      See identical proteins and their annotated locations for NP_001034137.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AJ278734, AL627253, AL627314, CJ131880, CK128385
      Consensus CDS
      CCDS38914.1
      UniProtKB/TrEMBL
      A2A9L4, F8VPZ1
      Related
      ENSMUSP00000101501.2, ENSMUST00000105875.8
      Conserved Domains (3) summary
      cd00162
      Location:2382
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:120159
      zf-B_box; B-box zinc finger
      cl23765
      Location:166283
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    2. NM_001369245.1NP_001356174.1  E3 ubiquitin-protein ligase TRIM63 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627253, AL627314
      UniProtKB/TrEMBL
      A2A9L4, B9EJZ0
      Conserved Domains (3) summary
      smart00502
      Location:166283
      BBC; B-Box C-terminal domain
      pfam00643
      Location:120159
      zf-B_box; B-box zinc finger
      cd16759
      Location:1880
      RING-HC_MuRF1; RING finger, HC subclass, found in muscle-specific RING finger protein 1 (MuRF-1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      134042431..134056940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)