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    Slc15a3 solute carrier family 15, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 65221, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Slc15a3provided by MGI
    Official Full Name
    solute carrier family 15, member 3provided by MGI
    Primary source
    MGI:MGI:1929691
    See related
    Ensembl:ENSMUSG00000024737 AllianceGenome:MGI:1929691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ci1; cI-1
    Summary
    Enables peptidoglycan transmembrane transporter activity. Involved in peptidoglycan transport and positive regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway. Located in endosome membrane and lysosomal membrane. Is expressed in several structures, including brain; gut; hemolymphoid system; liver lobe; and testis. Orthologous to human SLC15A3 (solute carrier family 15 member 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in spleen adult (RPKM 18.7), lung adult (RPKM 15.6) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc15a3 in Genome Data Viewer
    Location:
    19 A; 19 7.23 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10819908..10835279)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10842544..10857915)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A430093F15 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10861955-10862189 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10862842-10863029 Neighboring gene CD6 antigen Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10903953-10904062 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10904315-10904608 Neighboring gene STARR-seq mESC enhancer starr_45559 Neighboring gene STARR-positive B cell enhancer ABC_E5688 Neighboring gene transmembrane protein 132A Neighboring gene STARR-positive B cell enhancer ABC_E2520 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10956481-10956590 Neighboring gene transmembrane protein 109 Neighboring gene STARR-positive B cell enhancer ABC_E8738 Neighboring gene pre-mRNA processing factor 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SLC15A3 plays a crucial role in pulmonary fibrosis by regulating macrophage oxidative stress. Luo J, et al. Cell Death Differ, 2024 Apr. PMID 38374230,
    2. The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid-sensing TLRs and ligands to endolysosomes. Rimann I, et al. Proc Natl Acad Sci U S A, 2022 Apr 5. PMID 35349343, Free PMC Article
    3. The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy. Kitakaze T, et al. Biochem Biophys Res Commun, 2016 Sep 23. PMID 27553280
    4. Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. Nakamura N, et al. Nature, 2014 May 8. PMID 24695226
    5. Identification of cAMP analogue inducible genes in RAW264 macrophages. Takahashi Y, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 11004510

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC15A3 plays a crucial role in pulmonary fibrosis by regulating macrophage oxidative stress.
      Title: SLC15A3 plays a crucial role in pulmonary fibrosis by regulating macrophage oxidative stress.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (6) 
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dipeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dipeptide transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptidoglycan transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dipeptide import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dipeptide import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dipeptide import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 15 member 3
    Names
    cAMP inducible gene 1
    cAMP-inducible gene 1 protein
    peptide transporter 3
    peptide/histidine transporter 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023044.2 → NP_075531.2  solute carrier family 15 member 3

      See identical proteins and their annotated locations for NP_075531.2

      Status: VALIDATED

      Source sequence(s)
      AC132402
      Consensus CDS
      CCDS29588.1
      UniProtKB/Swiss-Prot
      Q8BPX9, Q9WU80
      Related
      ENSMUSP00000025646.3, ENSMUST00000025646.3
      Conserved Domains (2) summary
      COG3104
      Location:41 → 567
      PTR2; Dipeptide/tripeptide permease [Amino acid transport and metabolism]
      cl21472
      Location:179 → 515
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10819908..10835279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BPX9.1 GenPept UniProtKB/Swiss-Prot:Q8BPX9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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