RXFP4 relaxin family peptide/INSL5 receptor 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RXFP4provided by HGNC
Official Full Name: relaxin family peptide/INSL5 receptor 4provided by HGNC
Primary source: HGNC:HGNC:14666
See related: Ensembl:ENSG00000173080 MIM:609043; AllianceGenome:HGNC:14666
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPR100; RLN3R2; RXFPR4; GPCR142
Summary: GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
Orthologs: mouse all
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Genomic context

Location:: 1q22

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (155941638..155943087)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (155079771..155081220)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (155911429..155912878)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4).
Title: Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4).
Expression of the relaxin family peptide 4 receptor by enterochromaffin cells of the mouse large intestine.
Title: Expression of the relaxin family peptide 4 receptor by enterochromaffin cells of the mouse large intestine.
present work shed new light on the interaction mechanism of RXFP3 and RXFP4 with agonists and antagonists, and also provided a novel approach for interaction studies of some plasma membrane receptors with their ligands.
Title: Exploring electrostatic interactions of relaxin family peptide receptor 3 and 4 with ligands using a NanoBiT-based binding assay.
The results confirmed the presence of RXFP4 in human spermatozoa, which localized in the neck and midpiece of sperm.
Title: Expression and localization of relaxin family peptide receptor 4 in human spermatozoa and impact of insulin-like peptide 5 on sperm functions.
The role of these four INSL5 determinants in distinguishing RXFP4 from RXFP3.
Title: Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4.
analysis of the interaction mechanism of INSL5 with its receptor RXFP4
Title: Interaction mechanism of insulin-like peptide 5 with relaxin family peptide receptor 4.
Relaxin-3 is a high-efficacy agonist at RXFP4 with a comparable signal transduction profile to INSL5.
Title: The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.
The C-terminus of the B-chain of human INSL5 is critical for cognate RXFP4 receptor activity.
Title: The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity.
electrostatic interactions between INSL5 and RXFP4
Title: Identification of important residues of insulin-like peptide 5 and its receptor RXFP4 for ligand-receptor interactions.
Mutant relaxin-3 shows a significant decrease in receptor-activation potency towards RXFP4.
Title: The electrostatic interactions of relaxin-3 with receptor RXFP4 and the influence of its B-chain C-terminal conformation.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GPR100_3738 (e-PCR)
- UniSTS:462217

NoName (e-PCR)
- UniSTS:483228

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of feeding behavior	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: relaxin-3 receptor 2

Names: G protein-coupled receptor 100; G-protein coupled receptor GPCR142; RLN3 receptor 2; insulin-like peptide INSL5 receptor; relaxin family peptide receptor 4; relaxin/insulin like family peptide receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.