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    ERR3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855373, updated on 11-Sep-2024

    Summary

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    Official Symbol
    ERR3
    Primary source
    SGD:S000004942
    Locus tag
    YMR323W
    See related
    AllianceGenome:SGD:S000004942; FungiDB:YMR323W; VEuPathDB:YMR323W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphopyruvate hydratase activity. Predicted to be involved in glycolytic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease and prostate cancer. Orthologous to human ENO1 (enolase 1); ENO2 (enolase 2); and ENO3 (enolase 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (920088..921401)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene glutathione-independent methylglyoxalase family protein Neighboring gene seripauperin PAU19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence analysis of the right end of chromosome XV in Saccharomyces cerevisiae: an insight into the structural and functional significance of sub-telomeric repeat sequences. Pryde FE, et al. Yeast, 1995 Apr 15. PMID 7785338
    2. The Saccharomyces cerevisiae enolase-related regions encode proteins that are active enolases. Kornblatt MJ, et al. Yeast, 2013 Feb. PMID 23359425
    3. The COG database: a tool for genome-scale analysis of protein functions and evolution. Tatusov RL, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592175, Free PMC Article
    4. Tritium suicide selection identifies proteins involved in the uptake and intracellular transport of sterols in Saccharomyces cerevisiae. Sullivan DP, et al. Eukaryot Cell, 2009 Feb. PMID 19060182, Free PMC Article
    5. Yeast Ssd1 is a non-enzymatic member of the RNase II family with an alternative RNA recognition site. Bayne RA, et al. Nucleic Acids Res, 2022 Mar 21. PMID 34302485, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopyruvate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopyruvate hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphopyruvate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopyruvate hydratase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    part_of phosphopyruvate hydratase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphopyruvate hydratase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphopyruvate hydratase ERR3
    NP_014056.3
    • Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant in glucose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      920088..921401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182836.3 → NP_014056.3  TPA: phosphopyruvate hydratase ERR3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014056.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0F0, P42222
      UniProtKB/TrEMBL
      A6ZLP5, A6ZVX7
      Conserved Domains (1) summary
      PTZ00081
      Location:1 → 428
      PTZ00081; enolase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42222.2

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