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    Fstl1 follistatin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 14314, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fstl1provided by MGI
    Official Full Name
    follistatin-like 1provided by MGI
    Primary source
    MGI:MGI:102793
    See related
    Ensembl:ENSMUSG00000022816 AllianceGenome:MGI:102793
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fstl; TSC-36
    Summary
    Predicted to enable calcium ion binding activity and heparin binding activity. Involved in endothelial cell differentiation; endothelial cell migration; and negative regulation of apoptotic process. Acts upstream of or within hematopoietic stem cell homeostasis. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; limb; and sensory organ. Used to study pulmonary emphysema. Orthologous to human FSTL1 (follistatin like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 177.9), bladder adult (RPKM 102.9) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fstl1 in Genome Data Viewer
    Location:
    16 B3; 16 26.48 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (37597417..37656878)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (37777055..37836516)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9 pseudogene Neighboring gene predicted gene, 46547 Neighboring gene STARR-seq mESC enhancer starr_40793 Neighboring gene STARR-seq mESC enhancer starr_40795 Neighboring gene STARR-seq mESC enhancer starr_40798 Neighboring gene predicted gene, 41452 Neighboring gene butyrophilin-like 12 Neighboring gene leucine rich repeat containing 58 Neighboring gene actin, beta, cytoplasmic (Actb) pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model. Shen H, et al. Stem Cell Res Ther, 2019 Jan 11. PMID 30635025, Free PMC Article
    2. Follistatin-like 1 deficiency impairs T cell development to promote lung metastasis of triple negative breast cancer. Ma J, et al. Aging (Albany NY), 2021 Feb 26. PMID 33639614, Free PMC Article
    3. Follistatin-like protein-1 is a novel proinflammatory molecule. Miyamae T, et al. J Immunol, 2006 Oct 1. PMID 16982916
    4. Muscle-derived follistatin-like 1 functions to reduce neointimal formation after vascular injury. Miyabe M, et al. Cardiovasc Res, 2014 Jul 1. PMID 24743592, Free PMC Article
    5. Knockdown of Follistatin-like 1 disrupts synaptic transmission in hippocampus and leads to cognitive impairments. Xiang S, et al. Exp Neurol, 2020 Nov. PMID 32721453

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Follistatin-like 1 protects against doxorubicin-induced cardiotoxicity by preventing mitochondrial dysfunction through the SIRT6/Nrf2 signaling pathway.
      Title: Follistatin-like 1 protects against doxorubicin-induced cardiotoxicity by preventing mitochondrial dysfunction through the SIRT6/Nrf2 signaling pathway.
    2. Endothelial extracellular vesicles induce acute lung injury via follistatin-like protein 1.
      Title: Endothelial extracellular vesicles induce acute lung injury via follistatin-like protein 1.
    3. Single-cell transcriptome analysis reveals cellular heterogeneity and highlights Fstl1-regulated alveolar myofibroblasts in mouse lung at birth.
      Title: Single-cell transcriptome analysis reveals cellular heterogeneity and highlights Fstl1-regulated alveolar myofibroblasts in mouse lung at birth.
    4. FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation.
      Title: FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation.
    5. miR-125a-3p regulates the expression of FSTL1, a pro-inflammatory factor, during adipogenic differentiation, and inhibits adipogenesis in mice.
      Title: miR-125a-3p regulates the expression of FSTL1, a pro-inflammatory factor, during adipogenic differentiation, and inhibits adipogenesis in mice.
    6. Follistatin-like 1 mitigates intermittent hypoxia-induced melanoma lung metastasis in mice.
      Title: Follistatin-like 1 mitigates intermittent hypoxia-induced melanoma lung metastasis in mice.
    7. FSTL1-knockdown improves neural oscillation via decreasing neuronal-inflammation regulating apoptosis in Abeta1-42 induced AD model mice.
      Title: FSTL1-knockdown improves neural oscillation via decreasing neuronal-inflammation regulating apoptosis in Aβ(1-42) induced AD model mice.
    8. FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2.
      Title: FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2.
    9. Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/beta-catenin signaling in obstructed kidneys in vivo.
      Title: Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo.
    10. Knockdown of FSTL1 inhibits microglia activation and alleviates depressive-like symptoms through modulating TLR4/MyD88/NF-kappaB pathway in CUMS mice.
      Title: Knockdown of FSTL1 inhibits microglia activation and alleviates depressive-like symptoms through modulating TLR4/MyD88/NF-κB pathway in CUMS mice.
    Submit: New GeneRIF Correction See all GeneRIFs (74)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endothelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space HDA PubMed 

    General protein information

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    Preferred Names
    follistatin-related protein 1
    Names
    TGF-beta-inducible protein TSC-36
    follistatin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008047.5 → NP_032073.2  follistatin-related protein 1 precursor

      See identical proteins and their annotated locations for NP_032073.2

      Status: PROVISIONAL

      Source sequence(s)
      AC129539
      Consensus CDS
      CCDS37339.1
      UniProtKB/Swiss-Prot
      Q62356, Q6GTX2, Q99JI9
      Related
      ENSMUSP00000110411.3, ENSMUST00000114763.3
      Conserved Domains (5) summary
      smart00274
      Location:29 → 51
      FOLN; Follistatin-N-terminal domain-like
      smart00280
      Location:52 → 96
      KAZAL; Kazal type serine protease inhibitors
      pfam13499
      Location:147 → 218
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:147 → 218
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl17735
      Location:231 → 278
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      37597417..37656878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62356.2 GenPept UniProtKB/Swiss-Prot:Q62356

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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