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    ZNF831 zinc finger protein 831 [ Homo sapiens (human) ]

    Gene ID: 128611, updated on 17-Jun-2024

    Summary

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    Official Symbol
    ZNF831provided by HGNC
    Official Full Name
    zinc finger protein 831provided by HGNC
    Primary source
    HGNC:HGNC:16167
    See related
    Ensembl:ENSG00000124203 AllianceGenome:HGNC:16167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C20orf174
    Summary
    Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lymph node (RPKM 2.3), spleen (RPKM 1.1) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF831 in Genome Data Viewer
    Location:
    20q13.32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (59123388..59259113)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (60906490..61042393)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (57698443..57834168)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904943 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:57638504-57639703 Neighboring gene NANOG hESC enhancer GRCh37_chr20:57681118-57681619 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:57697082-57697631 Neighboring gene mitochondrial ribosomal protein S16 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:57724967-57725189 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:57734401-57735226 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:57770614-57771813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13089 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:57893004-57893504 Neighboring gene Sharpr-MPRA regulatory region 9189 Neighboring gene endothelin 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:57950919-57951420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:57979490-57979990 Neighboring gene NANOG hESC enhancer GRCh37_chr20:58013205-58013760 Neighboring gene piezo type mechanosensitive ion channel component 1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genomewide association study of movement-related adverse antipsychotic effects. Aberg K, et al. Biol Psychiatry, 2010 Feb 1. PMID 19875103, Free PMC Article
    2. Genome-wide association study of blood pressure and hypertension. Levy D, et al. Nat Genet, 2009 Jun. PMID 19430479, Free PMC Article
    3. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. International Consortium for Blood Pressure Genome-Wide Association Studies, et al. Nature, 2011 Sep 11. PMID 21909115, Free PMC Article
    4. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Wain LV, et al. Nat Genet, 2011 Sep 11. PMID 21909110, Free PMC Article
    5. Identification of host proteins required for HIV infection through a functional genomic screen. Brass AL, et al. Science, 2008 Feb 15. PMID 18187620

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study of blood pressure and hypertension.
    EBI GWAS Catalog
    Genomewide association study of movement-related adverse antipsychotic effects.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 831 (ZNF831; C20orf174) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 831

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384354.1 → NP_001371283.1  zinc finger protein 831

      Status: VALIDATED

      Source sequence(s)
      AL121919, AL136532
      Consensus CDS
      CCDS42894.1
      UniProtKB/Swiss-Prot
      Q5JPB2, Q5TDR4, Q8TCP0
      Related
      ENSP00000490240.1, ENST00000637017.1
      Conserved Domains (2) summary
      sd00017
      Location:146 → 166
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:159 → 183
      zf-H2C2_2; Zinc-finger double domain

    2. NM_178457.3 → NP_848552.1  zinc finger protein 831

      See identical proteins and their annotated locations for NP_848552.1

      Status: VALIDATED

      Source sequence(s)
      AL121919
      Consensus CDS
      CCDS42894.1
      UniProtKB/Swiss-Prot
      Q5JPB2, Q5TDR4, Q8TCP0
      Related
      ENSP00000360069.2, ENST00000371030.4
      Conserved Domains (2) summary
      sd00017
      Location:146 → 166
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:159 → 183
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      59123388..59259113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439881.1 → XP_047295837.1  zinc finger protein 831 isoform X1

      UniProtKB/Swiss-Prot
      Q5JPB2, Q5TDR4, Q8TCP0

    2. XM_047439880.1 → XP_047295836.1  zinc finger protein 831 isoform X1

      UniProtKB/Swiss-Prot
      Q5JPB2, Q5TDR4, Q8TCP0

    3. XM_011528534.3 → XP_011526836.1  zinc finger protein 831 isoform X1

      See identical proteins and their annotated locations for XP_011526836.1

      UniProtKB/Swiss-Prot
      Q5JPB2, Q5TDR4, Q8TCP0
      Conserved Domains (2) summary
      sd00017
      Location:146 → 166
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:159 → 183
      zf-H2C2_2; Zinc-finger double domain

    4. XM_006723698.4 → XP_006723761.1  zinc finger protein 831 isoform X1

      See identical proteins and their annotated locations for XP_006723761.1

      UniProtKB/Swiss-Prot
      Q5JPB2, Q5TDR4, Q8TCP0
      Conserved Domains (2) summary
      sd00017
      Location:146 → 166
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:159 → 183
      zf-H2C2_2; Zinc-finger double domain

    5. XM_011528540.3 → XP_011526842.1  zinc finger protein 831 isoform X2

      Conserved Domains (2) summary
      sd00017
      Location:146 → 166
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:159 → 183
      zf-H2C2_2; Zinc-finger double domain

    6. XM_011528536.3 → XP_011526838.1  zinc finger protein 831 isoform X1

      See identical proteins and their annotated locations for XP_011526838.1

      UniProtKB/Swiss-Prot
      Q5JPB2, Q5TDR4, Q8TCP0
      Conserved Domains (2) summary
      sd00017
      Location:146 → 166
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:159 → 183
      zf-H2C2_2; Zinc-finger double domain

    7. XM_047439882.1 → XP_047295838.1  zinc finger protein 831 isoform X1

      UniProtKB/Swiss-Prot
      Q5JPB2, Q5TDR4, Q8TCP0

    8. XM_011528537.3 → XP_011526839.1  zinc finger protein 831 isoform X1

      See identical proteins and their annotated locations for XP_011526839.1

      UniProtKB/Swiss-Prot
      Q5JPB2, Q5TDR4, Q8TCP0
      Conserved Domains (2) summary
      sd00017
      Location:146 → 166
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:159 → 183
      zf-H2C2_2; Zinc-finger double domain

    9. XM_005260273.4 → XP_005260330.1  zinc finger protein 831 isoform X1

      See identical proteins and their annotated locations for XP_005260330.1

      UniProtKB/Swiss-Prot
      Q5JPB2, Q5TDR4, Q8TCP0
      Conserved Domains (2) summary
      sd00017
      Location:146 → 166
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:159 → 183
      zf-H2C2_2; Zinc-finger double domain

    10. XM_011528538.3 → XP_011526840.1  zinc finger protein 831 isoform X1

      See identical proteins and their annotated locations for XP_011526840.1

      UniProtKB/Swiss-Prot
      Q5JPB2, Q5TDR4, Q8TCP0
      Conserved Domains (2) summary
      sd00017
      Location:146 → 166
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:159 → 183
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      60906490..61042393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322952.1 → XP_054178927.1  zinc finger protein 831 isoform X1

    2. XM_054322953.1 → XP_054178928.1  zinc finger protein 831 isoform X1

    3. XM_054322955.1 → XP_054178930.1  zinc finger protein 831 isoform X1

    4. XM_054322960.1 → XP_054178935.1  zinc finger protein 831 isoform X2

    5. XM_054322954.1 → XP_054178929.1  zinc finger protein 831 isoform X1

    6. XM_054322959.1 → XP_054178934.1  zinc finger protein 831 isoform X1

    7. XM_054322956.1 → XP_054178931.1  zinc finger protein 831 isoform X1

    8. XM_054322958.1 → XP_054178933.1  zinc finger protein 831 isoform X1

    9. XM_054322957.1 → XP_054178932.1  zinc finger protein 831 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JPB2.4 GenPept UniProtKB/Swiss-Prot:Q5JPB2

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