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    comA two-component response quorum-sensing regulator [ Bacillus subtilis subsp. subtilis str. 168 ]

    Gene ID: 937179, updated on 6-Oct-2023

    Summary

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    Gene symbol
    comA
    Gene description
    two-component response quorum-sensing regulator
    Locus tag
    BSU_31680
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
    Lineage
    Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
    Old locus tag
    BSU31680
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    Genomic context

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    Sequence:
    NC_000964.3 (3252804..3253448, complement)

    NC_000964.3Genomic Context describing neighboring genes Neighboring gene efflux transporter for Na+ and cholate Neighboring gene non essential component of Na+/H+ antiporter Neighboring gene putative proofreading thioesterase in bacillibactin biosynthesis Neighboring gene two-component sensor histidine kinase Neighboring gene competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified) Neighboring gene isoprenyl transferase (pre-ComX modification)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000964.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The quorum-sensing regulator ComA from Bacillus subtilis activates transcription using topologically distinct DNA motifs.
      Title: The quorum-sensing regulator ComA from Bacillus subtilis activates transcription using topologically distinct DNA motifs.
    2. Using NMR spectroscopy, the high-resolution 3D solution structure of the C-terminal DNA-binding domain of ComA (ComAC) has been determined.
      Title: NMR solution structure and DNA-binding model of the DNA-binding domain of competence protein A.
    3. Data show that purified ComA forms a dimer in solution, and proposed a model for how two dimers of ComA bind to an odd number of DNA-binding determinants to activate transcription of target genes.
      Title: A degenerate tripartite DNA-binding site required for activation of ComA-dependent quorum response gene expression in Bacillus subtilis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    two-component response quorum-sensing regulator
    NP_391046.1
    • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000964.3 Reference assembly

      Range
      3252804..3253448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_391046.1 two-component response quorum-sensing regulator [Bacillus subtilis subsp. subtilis str. 168]

      See identical proteins and their annotated locations for NP_391046.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A386RVJ5
      Conserved Domains (1) summary
      COG2197
      Location:3 → 214
      CitB; DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14204.1

    Gene LinkOut

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    Other Literature Sources
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    Research Materials