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    spo0A response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT [ Bacillus subtilis subsp. subtilis str. 168 ]

    Gene ID: 938655, updated on 6-Oct-2023

    Summary

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    Gene symbol
    spo0A
    Gene description
    response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT
    Locus tag
    BSU_24220
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
    Lineage
    Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
    Old locus tag
    BSU24220
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    Genomic context

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    Sequence:
    NC_000964.3 (2518023..2518826, complement)

    NC_000964.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene putative NADH-dependent flavin oxidoreductase Neighboring gene regulatory membrane-associated serine protease Neighboring gene factor for double strand breaks DNA repair and genetic recombination

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000964.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MecA inhibits the transcription of several Spo0A-P activated genes, but fails to de-repress several Spo0A-P repressed promoters.
      Title: ClpC and MecA, components of a proteolytic machine, prevent Spo0A-P-dependent transcription without degradation.
    2. Cells exhibit a constant probability of attaining a high threshold level of Spo0A~P due to fluctuations in the flux of phosphoryl groups through the phosphorelay.
      Title: Noise in a phosphorelay drives stochastic entry into sporulation in Bacillus subtilis.
    3. our findings indicate that distinct Rho-controlled transcripts are functional and constitute a previously unknown built-in module for the control of cell differentiation in B. subtilis. In a broader context, our results highlight the recruitment of the termination factor Rho, for which the conserved biological role is probably to repress pervasive transcription, in highly integrated, bacterium-specific, regulatory network
      Title: Termination factor Rho: From the control of pervasive transcription to cell fate determination in Bacillus subtilis.
    4. The pulsed behavior of Spo0A~P allows the introduction of a time delay between the activations of KinA and Spo0A~P. (Review)
      Title: Coordination of cell decisions and promotion of phenotypic diversity in B. subtilis via pulsed behavior of the phosphorelay.
    5. Spo0A binds to the upstream region of epr promoter and in turn occludes the binding site of one of the co-repressor, SinR.
      Title: Spo0A positively regulates epr expression by negating the repressive effect of co-repressors, SinR and ScoC, in Bacillus subtilis.
    6. Spo0A regulates chromosome copy number during sporulation by binding to the origin of replication.
      Title: Spo0A regulates chromosome copy number during sporulation by directly binding to the origin of replication in Bacillus subtilis.
    7. Spo0A synthes is governed by a promoter switching mechanism during different growth stages.
      Title: Just-in-time control of Spo0A synthesis in Bacillus subtilis by multiple regulatory mechanisms.
    8. Phosphorylation of Spo0A by the histidine kinase KinD requires the lipoprotein med.
      Title: Phosphorylation of Spo0A by the histidine kinase KinD requires the lipoprotein med in Bacillus subtilis.
    9. The increase in spo0A transcription during early growth phase results in the synthesis of phosphorylated Spo0A.
      Title: Fluctuations in spo0A transcription control rare developmental transitions in Bacillus subtilis.
    10. kinC and kinD are responsible for expression of spo0A during logarithmical growth that are not sufficient to activate sporulation, but sufficient for suppression of the lytic cycle of phi 29.
      Title: kinC/D-mediated heterogeneous expression of spo0A during logarithmical growth in Bacillus subtilis is responsible for partial suppression of phi 29 development.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    General gene information

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    Homology

    General protein information

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    Preferred Names
    response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT
    NP_390302.1
    • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000964.3 Reference assembly

      Range
      2518023..2518826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_390302.1 response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT [Bacillus subtilis subsp. subtilis str. 168]

      See identical proteins and their annotated locations for NP_390302.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0D1L772
      Conserved Domains (1) summary
      TIGR02875
      Location:2 → 267
      spore_0_A; sporulation transcription factor Spo0A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06534.1

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials