Arrdc1 arrestin domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arrdc1provided by RGD
Official Full Name: arrestin domain containing 1provided by RGD
Primary source: RGD:1309961
See related: EnsemblRapid:ENSRNOG00000007622 AllianceGenome:RGD:1309961
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including arrestin family protein binding activity; ubiquitin ligase-substrate adaptor activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; extracellular vesicle biogenesis; and negative regulation of Notch signaling pathway. Predicted to be located in cytoplasmic vesicle; extracellular vesicle; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ARRDC1 (arrestin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 198.9), Kidney (RPKM 99.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28133190..28140378, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (7735002..7742195, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2129876..2137161, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arrestin family protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in extracellular transport	ISO Inferred from Sequence Orthology more info
involved_in extracellular transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in extracellular vesicle biogenesis	ISO Inferred from Sequence Orthology more info
involved_in extracellular vesicle biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
NOT located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular vesicle	ISO Inferred from Sequence Orthology more info
located_in extracellular vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: arrestin domain-containing protein 1

Names: alpha-arrestin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100770.1 → NP_001094240.1 arrestin domain-containing protein 1

See identical proteins and their annotated locations for NP_001094240.1

Status: PROVISIONAL

Source sequence(s)

BC158871

UniProtKB/Swiss-Prot

B0BNL6, Q68FT0

Related

ENSRNOP00000010169.4, ENSRNOT00000010169.7

Conserved Domains (3) summary

PHA03247
Location:285 → 423

PHA03247; large tegument protein UL36; Provisional

pfam02752
Location:162 → 284

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

cl22903
Location:7 → 139

Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

28133190..28140378 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105577.2 → XP_038961505.1 arrestin domain-containing protein 1 isoform X4

Conserved Domains (3) summary

PHA03247
Location:274 → 412

PHA03247; large tegument protein UL36; Provisional

pfam02752
Location:125 → 273

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

cl22903
Location:14 → 102

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_039105576.2 → XP_038961504.1 arrestin domain-containing protein 1 isoform X2

Conserved Domains (3) summary

PHA03247
Location:310 → 448

PHA03247; large tegument protein UL36; Provisional

pfam02752
Location:162 → 309

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

cl22903
Location:7 → 139

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_039105575.2 → XP_038961503.1 arrestin domain-containing protein 1 isoform X1

Conserved Domains (3) summary

PHA03247
Location:311 → 449

PHA03247; large tegument protein UL36; Provisional

pfam02752
Location:162 → 310

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

cl22903
Location:7 → 139

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_006233631.5 → XP_006233693.1 arrestin domain-containing protein 1 isoform X5

See identical proteins and their annotated locations for XP_006233693.1

UniProtKB/TrEMBL

A6JSZ3

Related

ENSRNOP00000105854.1, ENSRNOT00000160561.1

Conserved Domains (2) summary

pfam02752
Location:125 → 247

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

cl22903
Location:14 → 102

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_006233630.5 → XP_006233692.1 arrestin domain-containing protein 1 isoform X3

Conserved Domains (3) summary

PHA03247
Location:284 → 422

PHA03247; large tegument protein UL36; Provisional

pfam02752
Location:162 → 283

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

cl22903
Location:7 → 139

Arrestin_N; Arrestin (or S-antigen), N-terminal domain