OAZ1 ornithine decarboxylase antizyme 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: OAZ1provided by VGNC
Official Full Name: ornithine decarboxylase antizyme 1provided by VGNC
Primary source: VGNC:VGNC:98166
See related: Ensembl:ENSSSCG00000013460
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: AZ1
Summary: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jul 2014]
Expression: Ubiquitous expression in spleen (RPKM 341.8), lung (RPKM 292.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	2	NC_010444.4 (76293142..76296626, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	2	NC_010444.3 (76854941..76858425, complement)

Chromosome 2 - NC_010444.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression patterns showed that in Lantang pig, the AZ1 gene is differentially expressed in various tissues and displayed higher expression in lung and skeletal muscle
Title: Molecular characterization, tissue expression and nucleotide variation of the porcine AZ1 gene.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:495122

RH71137 (e-PCR)
- UniSTS:53041

OAZ1 (e-PCR)
- UniSTS:278862

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ornithine decarboxylase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ornithine decarboxylase antizyme 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122994.2 → NP_001116466.1 ornithine decarboxylase antizyme 1

See identical proteins and their annotated locations for NP_001116466.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the protein-coding transcript.

Source sequence(s)

AK392488, BW984205, EW617964

UniProtKB/TrEMBL

B2CR15, F1S8I3

Related

ENSSSCP00000014307.5, ENSSSCT00000014704.5

Conserved Domains (1) summary

pfam02100
Location:136 → 217

ODC_AZ; Ornithine decarboxylase antizyme

RNA

NR_125342.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an additional internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK392488, BW967753, BW984205, EW617964