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    CCK cholecystokinin [ Sus scrofa (pig) ]

    Gene ID: 397468, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CCKprovided by VGNC
    Official Full Name
    cholecystokininprovided by VGNC
    Primary source
    VGNC:VGNC:86334
    See related
    Ensembl:ENSSSCG00000011277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Restricted expression toward heart (RPKM 472.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See CCK in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 13 NC_010455.5 (25940674..25945879, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 13 NC_010455.4 (28610211..28615371, complement)

    Chromosome 13 - NC_010455.5Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene trafficking kinesin protein 1 Neighboring gene uncharacterized LOC110256272 Neighboring gene lysozyme like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Synthesis of cholecystokinin-pancreozymin. I. The C-terminal dodecapeptide. Ondetti MA, et al. J Am Chem Soc, 1970 Jan 14. PMID 5410106
    2. Cloned cDNA to cholecystokinin mRNA predicts an identical preprocholecystokinin in pig brain and gut. Gubler U, et al. Proc Natl Acad Sci U S A, 1984 Jul. PMID 6205394, Free PMC Article
    3. Analysis of sequence requirements for protein tyrosine sulfation. Rosenquist GL, et al. Protein Sci, 1993 Feb. PMID 8443599, Free PMC Article
    4. Polymerase chain reaction-based polymorphisms in the porcine cholecystokinin (CCK) gene and assignment to chromosome 13. Clutter AC, et al. Anim Genet, 1996 Oct. PMID 8930082
    5. Nonsulfated cholecystokinins in cerebral neurons. Agersnap M, et al. Neuropeptides, 2016 Dec. PMID 27535680

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Haemodynamic changes seem to regulate regional proCCK expression in the mammalian heart.
      Title: Cardiac procholecystokinin expression during haemodynamic changes in the mammalian heart.
    2. We conclude that only a small fraction of neuronal CCK is nonsulfated. The intracellular distribution of nonsulfated CCK in neurons suggests that they contribute only modestly to the CCK transmitter activity.
      Title: Nonsulfated cholecystokinins in cerebral neurons.
    3. Cardiac expression of pro-cholecystokinin is cell-specific, which differentiates the expression from that of intestinal endocrine cells and cerebral neurons.
      Title: Cardiomyocyte expression and cell-specific processing of procholecystokinin.
    4. This review explores the role of luminal cholecystokinin on the regulation of exocrine pancreatic secretion in author's studies of neonatal pigs.
      Title: Luminal CCK and its neuronal action on exocrine pancreatic secretion.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cholecystokinin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214237.2 → NP_999402.1  cholecystokinin precursor

      See identical proteins and their annotated locations for NP_999402.1

      Status: VALIDATED

      Source sequence(s)
      AEMK02000085, EW238422
      UniProtKB/Swiss-Prot
      P01356
      UniProtKB/TrEMBL
      A0A4X1TLX5
      Related
      ENSSSCP00000012023.4, ENSSSCT00000012346.5
      Conserved Domains (1) summary
      pfam00918
      Location:4 → 114
      Gastrin; Gastrin/cholecystokinin family

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010455.5 Reference Sscrofa11.1 Primary Assembly

      Range
      25940674..25945879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021068544.1 → XP_020924203.1  cholecystokinin isoform X2

      UniProtKB/TrEMBL
      A0A2C9F3A0, A0A8D0UFZ8, A0A8D1A2Z0
      Conserved Domains (1) summary
      pfam00918
      Location:44 → 154
      Gastrin; Gastrin/cholecystokinin family

    2. XM_005669402.3 → XP_005669459.3  cholecystokinin isoform X1

      UniProtKB/TrEMBL
      A0A8D1A2Z0
      Conserved Domains (1) summary
      pfam00918
      Location:44 → 164
      Gastrin; Gastrin/cholecystokinin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01356.1 GenPept UniProtKB/Swiss-Prot:P01356

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.