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    SIGLEC10 sialic acid binding Ig like lectin 10 [ Homo sapiens (human) ]

    Gene ID: 89790, updated on 6-Jun-2024

    Summary

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    Official Symbol
    SIGLEC10provided by HGNC
    Official Full Name
    sialic acid binding Ig like lectin 10provided by HGNC
    Primary source
    HGNC:HGNC:15620
    See related
    Ensembl:ENSG00000142512 MIM:606091; AllianceGenome:HGNC:15620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLG2; PRO940; SIGLEC-10
    Summary
    SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
    Expression
    Biased expression in appendix (RPKM 14.2), spleen (RPKM 13.0) and 12 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SIGLEC10 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51410020..51417642, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54498651..54506273, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51913274..51920896, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene chromosome 19 open reading frame 84 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:51897116-51897712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15015 Neighboring gene NIFK pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51912204-51912704 Neighboring gene SIGLEC10 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15018 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51941886-51942056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15020 Neighboring gene sialic acid binding Ig like lectin 8 Neighboring gene sialic acid binding Ig like lectin 25, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long-Term Elevated Siglec-10 in Cerebral Spinal Fluid Heralds Better Prognosis for Patients with Aneurysmal Subarachnoid Hemorrhage. Gao S, et al. Dis Markers, 2022. PMID 36188429, Free PMC Article
    2. Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples. Zhang C, et al. Front Med, 2022 Aug. PMID 35075579
    3. A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides. Alborzian Deh Sheikh A, et al. J Autoimmun, 2021 Jan. PMID 33223341
    4. Siglec-10 expression is up-regulated in activated human CD4(+) T cells. Bandala-Sanchez E, et al. Hum Immunol, 2020 Feb-Mar. PMID 32046870
    5. Siglec-10 is associated with survival and natural killer cell dysfunction in hepatocellular carcinoma. Zhang P, et al. J Surg Res, 2015 Mar. PMID 25450598

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Siglec10 Expression on Tumor-associated Macrophages Is an Independent Prognostic Factor in Stage I Lung Adenocarcinoma.
      Title: Siglec10 Expression on Tumor-associated Macrophages Is an Independent Prognostic Factor in Stage I Lung Adenocarcinoma.
    2. Gene expression patterns of CRYM and SIGLEC10 in Alzheimer's disease: potential early diagnostic indicators.
      Title: Gene expression patterns of CRYM and SIGLEC10 in Alzheimer's disease: potential early diagnostic indicators.
    3. High Expression and Significance of Siglec10/CD24 in Unexplained Missed Abortion.
      Title: High Expression and Significance of Siglec10/CD24 in Unexplained Missed Abortion.
    4. Long-Term Elevated Siglec-10 in Cerebral Spinal Fluid Heralds Better Prognosis for Patients with Aneurysmal Subarachnoid Hemorrhage.
      Title: Long-Term Elevated Siglec-10 in Cerebral Spinal Fluid Heralds Better Prognosis for Patients with Aneurysmal Subarachnoid Hemorrhage.
    5. Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples.
      Title: Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples.
    6. A Guillain-Barre syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides.
      Title: A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides.
    7. Novel insights into the function of CD24: A driving force in cancer.
      Title: Novel insights into the function of CD24: A driving force in cancer.
    8. Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10.
      Title: Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10.
    9. Siglec-10 expression is up-regulated in activated human CD4(+) T cells.
      Title: Siglec-10 expression is up-regulated in activated human CD4(+) T cells.
    10. Genetic ablation of either CD24 or Siglec-10, as well as blockade of the CD24-Siglec-10 interaction using monoclonal antibodies, robustly augment the phagocytosis of all CD24-expressing human tumours that we tested. Genetic ablation and therapeutic blockade of CD24 resulted in a macrophage-dependent reduction of tumour growth in vivo and an increase in survival time.
      Title: CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126774

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH2 domain binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sialic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of inflammatory response to wounding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sialic acid-binding Ig-like lectin 10
    Names
    sialic acid binding Ig-like lectin 10 Ig-like lectin 7
    siglec-like gene 2
    siglec-like protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171156.2 → NP_001164627.1  sialic acid-binding Ig-like lectin 10 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001164627.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC008750
      Consensus CDS
      CCDS54303.1
      UniProtKB/TrEMBL
      B7ZL06
      Related
      ENSP00000389132.2, ENST00000439889.6
      Conserved Domains (4) summary
      cd00096
      Location:320 → 381
      Ig; Immunoglobulin domain
      smart00408
      Location:211 → 272
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:309 → 384
      IG_like; Immunoglobulin like
      cl11960
      Location:23 → 140
      Ig; Immunoglobulin domain

    2. NM_001171157.2 → NP_001164628.1  sialic acid-binding Ig-like lectin 10 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001164628.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC008750
      Consensus CDS
      CCDS54305.1
      UniProtKB/TrEMBL
      B7ZL04
      Related
      ENSP00000342389.5, ENST00000353836.9
      Conserved Domains (3) summary
      cd00096
      Location:146 → 150
      Ig; Ig strand A [structural motif]
      cd05712
      Location:21 → 140
      IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
      cl11960
      Location:146 → 233
      Ig; Immunoglobulin domain

    3. NM_001171158.2 → NP_001164629.1  sialic acid-binding Ig-like lectin 10 isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame segment and an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (4) lacks two internal segments, as compared to isoform 1.
      Source sequence(s)
      AC008750
      Consensus CDS
      CCDS54304.1
      UniProtKB/TrEMBL
      B7ZL04
      Related
      ENSP00000414324.2, ENST00000436984.6
      Conserved Domains (4) summary
      cd00096
      Location:330 → 391
      Ig; Immunoglobulin domain
      smart00408
      Location:221 → 282
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:319 → 394
      IG_like; Immunoglobulin like
      cl11960
      Location:23 → 140
      Ig; Immunoglobulin domain

    4. NM_001171159.2 → NP_001164630.1  sialic acid-binding Ig-like lectin 10 isoform 5 precursor

      See identical proteins and their annotated locations for NP_001164630.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an in-frame segment and an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (5) lacks two internal segments, as compared to isoform 1.
      Source sequence(s)
      AC008750
      Consensus CDS
      CCDS54302.1
      UniProtKB/TrEMBL
      B7ZL04
      Related
      ENSP00000408387.2, ENST00000441969.7
      Conserved Domains (4) summary
      cd00096
      Location:320 → 381
      Ig; Immunoglobulin domain
      smart00408
      Location:211 → 272
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:309 → 384
      IG_like; Immunoglobulin like
      cl11960
      Location:23 → 140
      Ig; Immunoglobulin domain

    5. NM_001171161.2 → NP_001164632.1  sialic acid-binding Ig-like lectin 10 isoform 7 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an in-frame segment and two in-frame exons in the CDS, as compared to variant 1. The resulting isoform (7) lacks three internal segments, as compared to isoform 1.
      Source sequence(s)
      AC008750
      Consensus CDS
      CCDS54301.1
      UniProtKB/Swiss-Prot
      Q96LC7
      Related
      ENSP00000395475.2, ENST00000442846.7
      Conserved Domains (3) summary
      cd00096
      Location:230 → 291
      Ig; Immunoglobulin domain
      smart00410
      Location:219 → 294
      IG_like; Immunoglobulin like
      cl11960
      Location:23 → 140
      Ig; Immunoglobulin domain

    6. NM_001322105.2 → NP_001309034.1  sialic acid-binding Ig-like lectin 10 isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AC008750
      Consensus CDS
      CCDS82384.1
      UniProtKB/TrEMBL
      B7ZL04, E9PL79
      Related
      ENSP00000431444.1, ENST00000525998.5
      Conserved Domains (3) summary
      cd00096
      Location:288 → 349
      Ig; Immunoglobulin domain
      smart00410
      Location:277 → 352
      IG_like; Immunoglobulin like
      cl11960
      Location:23 → 140
      Ig; Immunoglobulin domain

    7. NM_033130.5 → NP_149121.2  sialic acid-binding Ig-like lectin 10 isoform 1 precursor

      See identical proteins and their annotated locations for NP_149121.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC008750
      Consensus CDS
      CCDS12832.1
      UniProtKB/Swiss-Prot
      A8K1I5, A8K3C7, C9JJ33, C9JM10, F8W917, Q3MIR5, Q6UXI8, Q96G54, Q96LC7, Q96LC8
      UniProtKB/TrEMBL
      B7ZL06
      Related
      ENSP00000345243.4, ENST00000339313.10
      Conserved Domains (4) summary
      cd00096
      Location:378 → 439
      Ig; Immunoglobulin domain
      smart00408
      Location:269 → 330
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:367 → 442
      IG_like; Immunoglobulin like
      cl11960
      Location:23 → 140
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      51410020..51417642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439605.1 → XP_047295561.1  sialic acid-binding Ig-like lectin 10 isoform X6

      UniProtKB/TrEMBL
      B7ZL04

    2. XM_047439602.1 → XP_047295558.1  sialic acid-binding Ig-like lectin 10 isoform X3

      UniProtKB/TrEMBL
      B7ZL06

    3. XM_047439601.1 → XP_047295557.1  sialic acid-binding Ig-like lectin 10 isoform X2

      UniProtKB/TrEMBL
      B7ZL06

    4. XM_047439603.1 → XP_047295559.1  sialic acid-binding Ig-like lectin 10 isoform X4

      UniProtKB/TrEMBL
      B7ZL04

    5. XM_047439600.1 → XP_047295556.1  sialic acid-binding Ig-like lectin 10 isoform X1

      UniProtKB/TrEMBL
      B7ZL06
      Related
      ENST00000357375.4

    6. XM_005259367.5 → XP_005259424.1  sialic acid-binding Ig-like lectin 10 isoform X8

      UniProtKB/TrEMBL
      B7ZL06
      Conserved Domains (3) summary
      cd00096
      Location:230 → 291
      Ig; Immunoglobulin domain
      smart00410
      Location:219 → 294
      IG_like; Immunoglobulin like
      cl11960
      Location:23 → 140
      Ig; Immunoglobulin domain

    7. XM_047439604.1 → XP_047295560.1  sialic acid-binding Ig-like lectin 10 isoform X5

      UniProtKB/TrEMBL
      B7ZL06

    8. XM_005259366.6 → XP_005259423.1  sialic acid-binding Ig-like lectin 10 isoform X7

      UniProtKB/TrEMBL
      B7ZL06
      Conserved Domains (3) summary
      cd00096
      Location:288 → 349
      Ig; Immunoglobulin domain
      smart00410
      Location:277 → 352
      IG_like; Immunoglobulin like
      cl11960
      Location:23 → 140
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      54498651..54506273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322496.1 → XP_054178471.1  sialic acid-binding Ig-like lectin 10 isoform X8

      UniProtKB/TrEMBL
      B7ZL06

    2. XM_054322494.1 → XP_054178469.1  sialic acid-binding Ig-like lectin 10 isoform X5

      UniProtKB/TrEMBL
      B7ZL06

    3. XM_054322495.1 → XP_054178470.1  sialic acid-binding Ig-like lectin 10 isoform X7

      UniProtKB/TrEMBL
      B7ZL06

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001171160.1: Suppressed sequence

      Description
      NM_001171160.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96LC7.3 GenPept UniProtKB/Swiss-Prot:Q96LC7

    Gene LinkOut

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