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    ZFAND2A zinc finger AN1-type containing 2A [ Homo sapiens (human) ]

    Gene ID: 90637, updated on 28-Oct-2024

    Summary

    Official Symbol
    ZFAND2Aprovided by HGNC
    Official Full Name
    zinc finger AN1-type containing 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:28073
    See related
    Ensembl:ENSG00000178381 MIM:610699; AllianceGenome:HGNC:28073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIRAP
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein targeting to ER. Predicted to act upstream of or within cellular response to arsenic-containing substance and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of proteasome complex. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 5.6), liver (RPKM 4.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZFAND2A in Genome Data Viewer
    Location:
    7p22.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (1148850..1160196, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (1248817..1259769, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1188486..1199832, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene chromosome 7 open reading frame 50 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1135129-1135838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1140145-1140645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1147881-1148424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1149827-1150667 Neighboring gene G protein-coupled estrogen receptor 1 Neighboring gene uncharacterized LOC102723758 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:1156037-1157236 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_97501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17843 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25488 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17845 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1185078-1185771 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:1198934-1199448 Neighboring gene hESC enhancers GRCh37_chr7:1199449-1199961 and GRCh37_chr7:1199962-1200475 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1200476-1200988 Neighboring gene ZFAND2A divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1209085-1210060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1210061-1211034 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17848 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:1220431-1221630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1232959-1233460 Neighboring gene Sharpr-MPRA regulatory region 5475 Neighboring gene VISTA enhancer hs293 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1273513-1274057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1274230-1275058 Neighboring gene UNC homeobox

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    AN1-type zinc finger protein 2A
    Names
    arsenite inducible RNA associated protein
    zinc finger, AN1-type domain 2A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365381.2NP_001352310.1  AN1-type zinc finger protein 2A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC091729
      Conserved Domains (1) summary
      pfam01428
      Location:1046
      zf-AN1; AN1-like Zinc finger
    2. NM_001365383.1NP_001352312.1  AN1-type zinc finger protein 2A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC091729
      Consensus CDS
      CCDS94044.1
      UniProtKB/TrEMBL
      A8K2A5, J3KQ25
      Related
      ENSP00000386031.1, ENST00000401903.6
      Conserved Domains (1) summary
      pfam01428
      Location:1046
      zf-AN1; AN1-like Zinc finger
    3. NM_182491.4NP_872297.2  AN1-type zinc finger protein 2A isoform 1

      See identical proteins and their annotated locations for NP_872297.2

      Status: VALIDATED

      Source sequence(s)
      AC091729, AI435373, BC029558
      Consensus CDS
      CCDS5323.1
      UniProtKB/Swiss-Prot
      A4D220, Q8N6M9
      UniProtKB/TrEMBL
      A8K2A5
      Related
      ENSP00000314619.3, ENST00000316495.8
      Conserved Domains (1) summary
      pfam01428
      Location:1046
      zf-AN1; AN1-like Zinc finger

    RNA

    1. NR_158186.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091729, BC016963, CD109464
      Related
      ENST00000397083.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      1148850..1160196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      1248817..1259769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)