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    AKR1B10 aldo-keto reductase family 1 member B10 [ Homo sapiens (human) ]

    Gene ID: 57016, updated on 11-Apr-2024

    Summary

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    Official Symbol
    AKR1B10provided by HGNC
    Official Full Name
    aldo-keto reductase family 1 member B10provided by HGNC
    Primary source
    HGNC:HGNC:382
    See related
    Ensembl:ENSG00000198074 MIM:604707; AllianceGenome:HGNC:382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12
    Summary
    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in duodenum (RPKM 190.1), stomach (RPKM 138.2) and 4 other tissues See more
    Orthologs
    all
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    Genomic context

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    See AKR1B10 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (134527567..134541412)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (135835650..135849492)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134212319..134226164)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:134132907-134134106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18673 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:134147917-134148417 Neighboring gene endogenous retrovirus group 3 member 1 pseudogene Neighboring gene aldo-keto reductase family 1 member B Neighboring gene Sharpr-MPRA regulatory region 13664 Neighboring gene uncharacterized LOC105375520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26690 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:134247191-134248390 Neighboring gene aldo-keto reductase family 1 member B15 Neighboring gene uncharacterized LOC124901750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26691 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26693 Neighboring gene Sharpr-MPRA regulatory region 13526 Neighboring gene bisphosphoglycerate mutase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of AKR1B10 Predicts Poor Prognosis in Gastric Cancer Patients Undergoing Surgical Resection. Liu YY, et al. Curr Oncol, 2022 Dec 21. PMID 36661656, Free PMC Article
    2. AKR1B10 accelerates the production of proinflammatory cytokines via the NF-κB signaling pathway in colon cancer. Liu C, et al. J Mol Histol, 2022 Oct. PMID 35920984
    3. Plasma Aldo-Keto Reductase Family 1 Member B10 as a Biomarker Performs Well in the Diagnosis of Nonalcoholic Steatohepatitis and Fibrosis. Park A, et al. Int J Mol Sci, 2022 May 1. PMID 35563425, Free PMC Article
    4. AKR1B10, One of the Triggers of Cytokine Storm in SARS-CoV2 Severe Acute Respiratory Syndrome. Chabert C, et al. Int J Mol Sci, 2022 Feb 8. PMID 35163833, Free PMC Article
    5. AKR1B10 inhibits the proliferation and migration of gastric cancer via regulating epithelial-mesenchymal transition. Shao X, et al. Aging (Albany NY), 2021 Sep 22. PMID 34552036, Free PMC Article

    See all (139) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aldo-keto Reductase 1B10 Restrains Cell Migration, Invasion, and Adhesion of Gastric Cancer via Regulating Integrin Subunit Alpha 5.
      Title: Aldo-keto Reductase 1B10 Restrains Cell Migration, Invasion, and Adhesion of Gastric Cancer via Regulating Integrin Subunit Alpha 5.
    2. Serum AKR1B10 as an indicator of unfavorable survival of hepatocellular carcinoma.
      Title: Serum AKR1B10 as an indicator of unfavorable survival of hepatocellular carcinoma.
    3. AKR1B10 regulates M2 macrophage polarization to promote the malignant phenotype of gastric cancer.
      Title: AKR1B10 regulates M2 macrophage polarization to promote the malignant phenotype of gastric cancer.
    4. RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression.
      Title: RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression.
    5. Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis.
      Title: Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis.
    6. Overexpression of AKR1B10 Predicts Poor Prognosis in Gastric Cancer Patients Undergoing Surgical Resection.
      Title: Overexpression of AKR1B10 Predicts Poor Prognosis in Gastric Cancer Patients Undergoing Surgical Resection.
    7. AKR1B10 accelerates the production of proinflammatory cytokines via the NF-kappaB signaling pathway in colon cancer.
      Title: AKR1B10 accelerates the production of proinflammatory cytokines via the NF-κB signaling pathway in colon cancer.
    8. Plasma Aldo-Keto Reductase Family 1 Member B10 as a Biomarker Performs Well in the Diagnosis of Nonalcoholic Steatohepatitis and Fibrosis.
      Title: Plasma Aldo-Keto Reductase Family 1 Member B10 as a Biomarker Performs Well in the Diagnosis of Nonalcoholic Steatohepatitis and Fibrosis.
    9. E2F1-mediated AUF1 upregulation promotes HCC development and enhances drug resistance via stabilization of AKR1B10.
      Title: E2F1-mediated AUF1 upregulation promotes HCC development and enhances drug resistance via stabilization of AKR1B10.
    10. AKR1B10, One of the Triggers of Cytokine Storm in SARS-CoV2 Severe Acute Respiratory Syndrome.
      Title: AKR1B10, One of the Triggers of Cytokine Storm in SARS-CoV2 Severe Acute Respiratory Syndrome.
    Submit: New GeneRIF Correction See all GeneRIFs (111)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC14103

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldo-keto reductase (NADPH) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables allyl-alcohol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables geranylgeranyl reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables indanol dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables retinal dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular detoxification of aldehyde IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in daunorubicin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in doxorubicin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in farnesol catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retinoid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retinoid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    aldo-keto reductase family 1 member B10
    Names
    ARP
    SI reductase
    aldo-keto reductase family 1, member B10 (aldose reductase)
    aldo-keto reductase family 1, member B11 (aldose reductase-like)
    aldose reductase-like 1
    aldose reductase-like peptide
    aldose reductase-related protein
    hARP
    small intestine reductase
    NP_064695.3
    XP_011514718.1
    XP_011514719.1
    XP_047276590.1
    XP_054214657.1
    XP_054214658.1
    XP_054214659.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020299.5 → NP_064695.3  aldo-keto reductase family 1 member B10

      See identical proteins and their annotated locations for NP_064695.3

      Status: REVIEWED

      Source sequence(s)
      AC078847, AF052577, AF524864, BC008837, BM975664
      Consensus CDS
      CCDS5832.1
      UniProtKB/Swiss-Prot
      A4D1P1, O60218, O75890, Q6FHF3, Q8IWZ1
      UniProtKB/TrEMBL
      A4D1P0
      Related
      ENSP00000352584.4, ENST00000359579.5
      Conserved Domains (1) summary
      cd19107
      Location:10 → 316
      AKR_AKR1B1-19; AKR1B family of aldo-keto reductase (AKR)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      134527567..134541412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516416.2 → XP_011514718.1  aldo-keto reductase family 1 member B10 isoform X2

      Conserved Domains (2) summary
      COG0656
      Location:1 → 258
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:16 → 250
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    2. XM_047420634.1 → XP_047276590.1  aldo-keto reductase family 1 member B10 isoform X1

    3. XM_011516417.3 → XP_011514719.1  aldo-keto reductase family 1 member B10 isoform X3

      Conserved Domains (2) summary
      COG0656
      Location:1 → 120
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:16 → 113
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      135835650..135849492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358683.1 → XP_054214658.1  aldo-keto reductase family 1 member B10 isoform X2

    2. XM_054358682.1 → XP_054214657.1  aldo-keto reductase family 1 member B10 isoform X1

    3. XM_054358684.1 → XP_054214659.1  aldo-keto reductase family 1 member B10 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60218.2 GenPept UniProtKB/Swiss-Prot:O60218

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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