Wnt4 wingless-type MMTV integration site family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 22417, updated on 2-Nov-2024

Summary

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Official Symbol: Wnt4provided by MGI
Official Full Name: wingless-type MMTV integration site family, member 4provided by MGI
Primary source: MGI:MGI:98957
See related: Ensembl:ENSMUSG00000036856 AllianceGenome:MGI:98957
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wnt-4
Summary: Enables frizzled binding activity and transcription corepressor activity. Involved in several processes, including negative regulation of testosterone biosynthetic process; positive regulation of cellular component biogenesis; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including epithelial cell differentiation; morphogenesis of an epithelium; and negative regulation of signal transduction. Located in cell surface; extracellular matrix; and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Orthologous to human WNT4 (Wnt family member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in adrenal adult (RPKM 48.0), ovary adult (RPKM 25.7) and 13 other tissues See more
Orthologs: human all
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Genomic context

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See Wnt4 in Genome Data Viewer

Location:: 4 D3; 4 69.8 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (137004946..137026812)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (137277635..137299501)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calcium signaling induces partial EMT and renal fibrosis in a Wnt4[mCherry] knock-in mouse model.
Title: Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model.
TEA domain transcription factor 1(TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway.
Title: TEA domain transcription factor 1(TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway.
A common allele increases endometrial Wnt4 expression, with antagonistic implications for pregnancy, reproductive cancers, and endometriosis.
Title: A common allele increases endometrial Wnt4 expression, with antagonistic implications for pregnancy, reproductive cancers, and endometriosis.
A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis.
Title: A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis.
CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice.
Title: CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice.
Loss of WNT4 in the gubernaculum causes unilateral cryptorchidism and fertility defects.
Title: Loss of WNT4 in the gubernaculum causes unilateral cryptorchidism and fertility defects.
Mice Lacking Wnt9a or Wnt4 Are Prone to Develop Spontaneous Osteoarthritis With Age and Display Alteration in Either the Trabecular or Cortical Bone Compartment.
Title: Mice Lacking Wnt9a or Wnt4 Are Prone to Develop Spontaneous Osteoarthritis With Age and Display Alteration in Either the Trabecular or Cortical Bone Compartment.
Wnt4 regulates bone metabolism through IKK-NF-kappaB and ROCK signaling under occlusal traumatic periodontitis.
Title: Wnt4 regulates bone metabolism through IKK-NF-κB and ROCK signaling under occlusal traumatic periodontitis.
Cell-intrinsic Wnt4 promotes hematopoietic stem and progenitor cell self-renewal.
Title: Cell-intrinsic Wnt4 promotes hematopoietic stem and progenitor cell self-renewal.
Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex.
Title: Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex.

Submit: New GeneRIF Correction See all GeneRIFs (93)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (13) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt4 (e-PCR), detects polymorphism
- UniSTS:465421

Wnt4 (e-PCR), detects polymorphism
- UniSTS:526100

Wnt4 (e-PCR), detects polymorphism
- UniSTS:471325

Wnt4 (e-PCR), detects polymorphism
- UniSTS:527139

Wnt4 (e-PCR), detects polymorphism
- UniSTS:525955

Wnt4 (e-PCR), detects polymorphism
- UniSTS:259460

Wnt4 (e-PCR), detects polymorphism
- UniSTS:259461

Wnt4 (e-PCR), detects polymorphism
- UniSTS:516494

NoName (e-PCR)
- UniSTS:485020

Wnt4 (e-PCR), detects polymorphism
- UniSTS:507319

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Sertoli cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell differentiation in thymus	IDA Inferred from Direct Assay more info	PubMed
involved_in adrenal gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anatomical structure development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-cell signaling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic epithelial tube formation	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female sex determination	ISO Inferred from Sequence Orthology more info
involved_in female sex determination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gamete generation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hormone metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immature T cell proliferation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in liver development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of meiotic nuclear division	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mesenchymal to epithelial transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesonephric tubule development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mesonephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric mesenchymal cell differentiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within metanephric nephron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephric nephron morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephric tubule formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephros development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of androgen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of androgen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of male gonad development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of male gonad development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of steroid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of testicular blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of testicular blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of testosterone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of wound healing	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within nephron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within non-canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oocyte development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within paramesonephric duct development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in paramesonephric duct development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in paramesonephric duct development	ISO Inferred from Sequence Orthology more info
involved_in paramesonephric duct development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within pericyte cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pericyte cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of aldosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of aldosterone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cortisol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cortisol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dermatome development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dermatome development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of focal adhesion assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of meiotic nuclear division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of stress fiber assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within renal vesicle formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within renal vesicle induction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within smooth muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatotropin secreting cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tertiary branching involved in mammary gland duct morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thyroid-stimulating hormone-secreting cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein Wnt-4

Names: signal molecule; wingless-related MMTV integration site 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.