KIF3C kinesin family member 3C [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIF3Cprovided by HGNC
Official Full Name: kinesin family member 3Cprovided by HGNC
Primary source: HGNC:HGNC:6321
See related: Ensembl:ENSG00000084731 MIM:602845; AllianceGenome:HGNC:6321
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable microtubule binding activity and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to act upstream of or within organelle transport along microtubule. Predicted to be located in microtubule cytoskeleton; neuronal cell body; and neuronal ribonucleoprotein granule. Predicted to be part of kinesin complex. Predicted to be active in microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in brain (RPKM 57.3), adrenal (RPKM 4.3) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 2p23.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (25926598..25982497, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (25961945..26017861, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (26149467..26205366, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis.
Title: Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis.
Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p).
Title: Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p).
KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
Title: KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway.
Title: KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway.
Results suggest that high expression of KIF3C in breast cancer may be associated with tumor progression and metastasis.
Title: Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-β signaling.
FMRP acts also as a molecular adaptor between RNA granules and the neurospecific kinesin KIF3C.
Title: The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of kinesin family member 3C (KIF3C) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

KIF3C_8426 (e-PCR)
- UniSTS:467738

RH66315 (e-PCR)
- UniSTS:47688

D2S1253 (e-PCR)
- UniSTS:149156

NoName (e-PCR)
- UniSTS:67245

HSC2CB052 (e-PCR)
- UniSTS:51408

RH12717 (e-PCR)
- UniSTS:32747

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	TAS Traceable Author Statement more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in ciliary tip	TAS Traceable Author Statement more info
located_in cilium	TAS Traceable Author Statement more info
located_in cytosol	TAS Traceable Author Statement more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin-like protein KIF3C

Names: KIF3C variant protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002254.8 → NP_002245.4 kinesin-like protein KIF3C

See identical proteins and their annotated locations for NP_002245.4

Status: VALIDATED

Source sequence(s)

AC013449, AC064847, KF456639

Consensus CDS

CCDS1719.1

UniProtKB/Swiss-Prot

O14782, O43544, Q4ZG18, Q53SX5, Q562F7

UniProtKB/TrEMBL

A2RU78, B7ZM25, Q7Z2W5

Related

ENSP00000264712.3, ENST00000264712.8

Conserved Domains (4) summary

cd01371
Location:9 → 365

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

pfam00225
Location:16 → 365

Kinesin; Kinesin motor domain

cd16269
Location:538 → 549

GBP_C; coiled coil [structural motif]

cl20817
Location:461 → 569

GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

25926598..25982497 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005264299.4 → XP_005264356.2 kinesin-like protein KIF3C isoform X1

UniProtKB/TrEMBL

B7ZM25

Conserved Domains (4) summary

cd01371
Location:9 → 365

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

pfam00225
Location:16 → 365

Kinesin; Kinesin motor domain

cd16269
Location:538 → 549

GBP_C; coiled coil [structural motif]

cl20817
Location:461 → 569

GBP_C; Guanylate-binding protein, C-terminal domain