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    ZNF438 zinc finger protein 438 [ Homo sapiens (human) ]

    Gene ID: 220929, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF438provided by HGNC
    Official Full Name
    zinc finger protein 438provided by HGNC
    Primary source
    HGNC:HGNC:21029
    See related
    Ensembl:ENSG00000183621 MIM:620749; AllianceGenome:HGNC:21029
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    bA330O11.1
    Summary
    Enables DNA-binding transcription factor activity. Involved in negative regulation of DNA-templated transcription. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.5), testis (RPKM 2.0) and 24 other tissues See more
    Orthologs
    mouse all
    NEW
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    Genomic context

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    See ZNF438 in Genome Data Viewer
    Location:
    10p11.23
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (30844632..31032411, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (30875934..31063684, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (31133561..31320794, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3227 Neighboring gene long intergenic non-protein coding RNA 2644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31072075-31072575 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31106665-31107586 Neighboring gene uncharacterized LOC124902405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31135691-31136191 Neighboring gene MPRA-validated peak916 silencer Neighboring gene DEAD-box helicase 10 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2271 Neighboring gene uncharacterized LOC105376481 Neighboring gene MPRA-validated peak918 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3233 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3234 Neighboring gene uncharacterized LOC105376482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2272 Neighboring gene uncharacterized LOC105376483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31435102-31435653 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31435654-31436204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:31498085-31498585 Neighboring gene long intergenic non-protein coding RNA 2664 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:31531588-31532787 Neighboring gene RNA, 5S ribosomal pseudogene 309

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel human zinc finger gene, ZNF438, with transcription inhibition activity. Zhong Z, et al. J Biochem Mol Biol, 2007 Jul 31. PMID 17669267
    2. Genome-wide association study of maternal and inherited effects on left-sided cardiac malformations. Mitchell LE, et al. Hum Mol Genet, 2015 Jan 1. PMID 25138779, Free PMC Article
    3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. International Multiple Sclerosis Genetics Consortium, et al. Nature, 2011 Aug 10. PMID 21833088, Free PMC Article
    4. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Okada Y, et al. Nature, 2014 Feb 20. PMID 24390342, Free PMC Article
    5. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. He M, et al. Hum Mol Genet, 2015 Mar 15. PMID 25429064, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    3. The transcriptional activity of ZNF438 was studied by transfecting recombinant pM-ZNF438 into mammalian cells. The subsequent analysis based on the duel luciferase assay system showed that ZNF438 was a transcriptional repressor.
      Title: Identification of a novel human zinc finger gene, ZNF438, with transcription inhibition activity.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog
    Genome-wide association study of maternal and inherited effects on left-sided cardiac malformations.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32761, MGC126671

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 438

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143766.2 → NP_001137238.1  zinc finger protein 438 isoform a

      See identical proteins and their annotated locations for NP_001137238.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1-4 encode the same isoform.
      Source sequence(s)
      AF428258, AI703004, AK292730, AL359532, DA513699
      Consensus CDS
      CCDS7168.1
      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    2. NM_001143767.2 → NP_001137239.1  zinc finger protein 438 isoform a

      See identical proteins and their annotated locations for NP_001137239.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      AF428258, AI703004, AL359532, DA402463
      Consensus CDS
      CCDS7168.1
      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Related
      ENSP00000387546.1, ENST00000413025.5
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    3. NM_001143768.2 → NP_001137240.1  zinc finger protein 438 isoform a

      See identical proteins and their annotated locations for NP_001137240.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      AF428258, AI703004, AL359532, DA479799
      Consensus CDS
      CCDS7168.1
      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Related
      ENSP00000406934.2, ENST00000436087.7
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    4. NM_001143769.2 → NP_001137241.1  zinc finger protein 438 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences in the 5' UTR, which results in the primary ORF beginning at a downstream start codon, compared to variant 1. The resulting protein (isoform c) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AF428258, AI703004, AK131357, AL359532, AL596113
      Consensus CDS
      CCDS53504.1
      UniProtKB/Swiss-Prot
      Q7Z4V0
      Related
      ENSP00000445461.1, ENST00000538351.6
      Conserved Domains (3) summary
      sd00017
      Location:460 → 480
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:472 → 497
      zf-H2C2_2; Zinc-finger double domain
      cl26464
      Location:49 → 315
      Atrophin-1; Atrophin-1 family

    5. NM_001143770.2 → NP_001137242.1  zinc finger protein 438 isoform b

      See identical proteins and their annotated locations for NP_001137242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and includes an additional exon in the 5' coding region which results in the primary ORF beginning at a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus, compared to isoform a. Both variants 6 and 7 encode the same isoform.
      Source sequence(s)
      AI703004, AL359532, DA513699, DQ356011
      Consensus CDS
      CCDS44369.1
      UniProtKB/Swiss-Prot
      Q7Z4V0
      Related
      ENSP00000413060.1, ENST00000452305.5
      Conserved Domains (2) summary
      sd00017
      Location:499 → 519
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:511 → 536
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001143771.2 → NP_001137243.1  zinc finger protein 438 isoform b

      See identical proteins and their annotated locations for NP_001137243.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and includes an additional exon in the 5' coding region which results in the primary ORF beginning at a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus, compared to isoform a. Both variants 6 and 7 encode the same isoform.
      Source sequence(s)
      AI703004, AL359532, DA513699, DQ356012
      Consensus CDS
      CCDS44369.1
      UniProtKB/Swiss-Prot
      Q7Z4V0
      Conserved Domains (2) summary
      sd00017
      Location:499 → 519
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:511 → 536
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001387405.1 → NP_001374334.1  zinc finger protein 438 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL359532, AL596113
      Consensus CDS
      CCDS7168.1
      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    8. NM_001387411.1 → NP_001374340.1  zinc finger protein 438 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL359532, AL359546
      Consensus CDS
      CCDS7168.1
      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    9. NM_001387412.1 → NP_001374341.1  zinc finger protein 438 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL359532, AL359546, AL596113
      Consensus CDS
      CCDS7168.1
      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    10. NM_182755.3 → NP_877432.1  zinc finger protein 438 isoform a

      See identical proteins and their annotated locations for NP_877432.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      AF428258, AI703004, AL359532, DA513699
      Consensus CDS
      CCDS7168.1
      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Related
      ENSP00000412363.1, ENST00000442986.5
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    RNA

    1. NR_026560.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and has an alternate splice pattern in the coding region, compared to variant 1. It is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AF428258, AI703004, AK057323, AL359532

    2. NR_170659.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL359532, AL359546

    3. NR_170660.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL359532, AL359546

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      30844632..31032411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424729.1 → XP_047280685.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    2. XM_024447871.2 → XP_024303639.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    3. XM_011519372.3 → XP_011517674.1  zinc finger protein 438 isoform X2

      See identical proteins and their annotated locations for XP_011517674.1

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    4. XM_047424739.1 → XP_047280695.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    5. XM_047424733.1 → XP_047280689.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    6. XM_047424746.1 → XP_047280702.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    7. XM_047424741.1 → XP_047280697.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    8. XM_024447872.2 → XP_024303640.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    9. XM_024447873.2 → XP_024303641.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    10. XM_047424734.1 → XP_047280690.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    11. XM_047424737.1 → XP_047280693.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    12. XM_006717399.4 → XP_006717462.1  zinc finger protein 438 isoform X3

      See identical proteins and their annotated locations for XP_006717462.1

      UniProtKB/Swiss-Prot
      Q7Z4V0
      Conserved Domains (2) summary
      sd00017
      Location:499 → 519
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:511 → 536
      zf-H2C2_2; Zinc-finger double domain

    13. XM_011519377.3 → XP_011517679.1  zinc finger protein 438 isoform X3

      See identical proteins and their annotated locations for XP_011517679.1

      UniProtKB/Swiss-Prot
      Q7Z4V0
      Conserved Domains (2) summary
      sd00017
      Location:499 → 519
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:511 → 536
      zf-H2C2_2; Zinc-finger double domain

    14. XM_017015877.2 → XP_016871366.1  zinc finger protein 438 isoform X5

      UniProtKB/TrEMBL
      B3KQ40, Q5T427, Q7Z4T7
      Related
      ENSP00000364460.1, ENST00000375311.1
      Conserved Domains (2) summary
      COG5048
      Location:47 → 126
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:73 → 93
      ZF_C2H2; C2H2 Zn finger [structural motif]

    15. XM_047424750.1 → XP_047280706.1  zinc finger protein 438 isoform X4

    16. XM_011519376.3 → XP_011517678.1  zinc finger protein 438 isoform X3

      See identical proteins and their annotated locations for XP_011517678.1

      UniProtKB/Swiss-Prot
      Q7Z4V0
      Conserved Domains (2) summary
      sd00017
      Location:499 → 519
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:511 → 536
      zf-H2C2_2; Zinc-finger double domain

    17. XM_047424724.1 → XP_047280680.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    18. XM_024447868.2 → XP_024303636.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    19. XM_047424728.1 → XP_047280684.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    20. XM_047424748.1 → XP_047280704.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    21. XM_047424738.1 → XP_047280694.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    22. XM_047424740.1 → XP_047280696.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    23. XM_024447870.2 → XP_024303638.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    24. XM_047424731.1 → XP_047280687.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    25. XM_047424730.1 → XP_047280686.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    26. XM_047424744.1 → XP_047280700.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    27. XM_047424749.1 → XP_047280705.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    28. XM_047424742.1 → XP_047280698.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    29. XM_047424745.1 → XP_047280701.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    30. XM_017015870.3 → XP_016871359.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    31. XM_011519373.4 → XP_011517675.1  zinc finger protein 438 isoform X2

      See identical proteins and their annotated locations for XP_011517675.1

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    32. XM_047424736.1 → XP_047280692.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    33. XM_047424735.1 → XP_047280691.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    34. XM_017015869.3 → XP_016871358.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    35. XM_047424725.1 → XP_047280681.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    36. XM_047424726.1 → XP_047280682.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    37. XM_047424732.1 → XP_047280688.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    38. XM_047424727.1 → XP_047280683.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    39. XM_024447869.2 → XP_024303637.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    40. XM_047424723.1 → XP_047280679.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    41. XM_047424747.1 → XP_047280703.1  zinc finger protein 438 isoform X2

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0

    42. XM_011519374.3 → XP_011517676.1  zinc finger protein 438 isoform X2

      See identical proteins and their annotated locations for XP_011517676.1

      UniProtKB/Swiss-Prot
      A2A3J4, A8K9L5, Q5T426, Q658Q4, Q6ZN65, Q7Z4V0
      Conserved Domains (4) summary
      PHA03247
      Location:98 → 364
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:507 → 529
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:535 → 558
      zf-C2H2_4; C2H2-type zinc finger

    43. XM_017015863.3 → XP_016871352.1  zinc finger protein 438 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      30875934..31063684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365047.1 → XP_054221022.1  zinc finger protein 438 isoform X2

    2. XM_054365044.1 → XP_054221019.1  zinc finger protein 438 isoform X2

    3. XM_054365035.1 → XP_054221010.1  zinc finger protein 438 isoform X2

    4. XM_054365060.1 → XP_054221035.1  zinc finger protein 438 isoform X2

    5. XM_054365052.1 → XP_054221027.1  zinc finger protein 438 isoform X2

    6. XM_054365067.1 → XP_054221042.1  zinc finger protein 438 isoform X2

    7. XM_054365065.1 → XP_054221040.1  zinc finger protein 438 isoform X2

    8. XM_054365049.1 → XP_054221024.1  zinc finger protein 438 isoform X2

    9. XM_054365054.1 → XP_054221029.1  zinc finger protein 438 isoform X2

    10. XM_054365053.1 → XP_054221028.1  zinc finger protein 438 isoform X2

    11. XM_054365057.1 → XP_054221032.1  zinc finger protein 438 isoform X2

    12. XM_054365071.1 → XP_054221046.1  zinc finger protein 438 isoform X3

    13. XM_054365072.1 → XP_054221047.1  zinc finger protein 438 isoform X3

    14. XM_054365074.1 → XP_054221049.1  zinc finger protein 438 isoform X5

      UniProtKB/TrEMBL
      Q5T427

    15. XM_054365073.1 → XP_054221048.1  zinc finger protein 438 isoform X4

    16. XM_054365070.1 → XP_054221045.1  zinc finger protein 438 isoform X3

    17. XM_054365038.1 → XP_054221013.1  zinc finger protein 438 isoform X2

    18. XM_054365034.1 → XP_054221009.1  zinc finger protein 438 isoform X2

    19. XM_054365046.1 → XP_054221021.1  zinc finger protein 438 isoform X2

    20. XM_054365068.1 → XP_054221043.1  zinc finger protein 438 isoform X2

    21. XM_054365059.1 → XP_054221034.1  zinc finger protein 438 isoform X2

    22. XM_054365062.1 → XP_054221037.1  zinc finger protein 438 isoform X2

    23. XM_054365037.1 → XP_054221012.1  zinc finger protein 438 isoform X2

    24. XM_054365050.1 → XP_054221025.1  zinc finger protein 438 isoform X2

    25. XM_054365048.1 → XP_054221023.1  zinc finger protein 438 isoform X2

    26. XM_054365066.1 → XP_054221041.1  zinc finger protein 438 isoform X2

    27. XM_054365069.1 → XP_054221044.1  zinc finger protein 438 isoform X2

    28. XM_054365063.1 → XP_054221038.1  zinc finger protein 438 isoform X2

    29. XM_054365041.1 → XP_054221016.1  zinc finger protein 438 isoform X2

    30. XM_054365058.1 → XP_054221033.1  zinc finger protein 438 isoform X2

    31. XM_054365045.1 → XP_054221020.1  zinc finger protein 438 isoform X2

    32. XM_054365056.1 → XP_054221031.1  zinc finger protein 438 isoform X2

    33. XM_054365055.1 → XP_054221030.1  zinc finger protein 438 isoform X2

    34. XM_054365061.1 → XP_054221036.1  zinc finger protein 438 isoform X2

    35. XM_054365039.1 → XP_054221014.1  zinc finger protein 438 isoform X2

    36. XM_054365042.1 → XP_054221017.1  zinc finger protein 438 isoform X2

    37. XM_054365051.1 → XP_054221026.1  zinc finger protein 438 isoform X2

    38. XM_054365043.1 → XP_054221018.1  zinc finger protein 438 isoform X2

    39. XM_054365040.1 → XP_054221015.1  zinc finger protein 438 isoform X2

    40. XM_054365036.1 → XP_054221011.1  zinc finger protein 438 isoform X2

    41. XM_054365064.1 → XP_054221039.1  zinc finger protein 438 isoform X2

    42. XM_054365033.1 → XP_054221008.1  zinc finger protein 438 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z4V0.1 GenPept UniProtKB/Swiss-Prot:Q7Z4V0

    Gene LinkOut

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