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    GPR34 G protein-coupled receptor 34 [ Homo sapiens (human) ]

    Gene ID: 2857, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPR34provided by HGNC
    Official Full Name
    G protein-coupled receptor 34provided by HGNC
    Primary source
    HGNC:HGNC:4490
    See related
    Ensembl:ENSG00000171659 MIM:300241; AllianceGenome:HGNC:4490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPS1; LYPSR1
    Summary
    G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006]
    Expression
    Broad expression in placenta (RPKM 8.9), fat (RPKM 7.8) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR34 in Genome Data Viewer
    Location:
    Xp11.4
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (41688973..41697275)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (41093901..41102205)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (41548226..41556528)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin dependent serine protein kinase Neighboring gene YWHAZ pseudogene 10 Neighboring gene RNA, 7SL, cytoplasmic 144, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:41570764-41571264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:41571265-41571765 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:41577964-41578464 Neighboring gene G protein-coupled receptor 82 Neighboring gene ribosomal protein S15a pseudogene 39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural basis for lysophosphatidylserine recognition by GPR34. Izume T, et al. Nat Commun, 2024 Feb 7. PMID 38326347, Free PMC Article
    2. Cryo-EM structures of human GPR34 enable the identification of selective antagonists. Xia A, et al. Proc Natl Acad Sci U S A, 2023 Sep 26. PMID 37733739, Free PMC Article
    3. G-protein Coupled Receptor 34 Promotes Gliomagenesis by Inducing Proliferation and Malignant Phenotype via TGF-Beta/Smad Signaling Pathway. Cheng Y, et al. Technol Cancer Res Treat, 2022 Jan-Dec. PMID 35770303, Free PMC Article
    4. Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1. Jacobi FK, et al. Hum Genet, 2000 Jul. PMID 10982042
    5. GPR34 activation potentially bridges lymphoepithelial lesions to genesis of salivary gland MALT lymphoma. Korona B, et al. Blood, 2022 Apr 7. PMID 34086889

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for lysophosphatidylserine recognition by GPR34.
      Title: Structural basis for lysophosphatidylserine recognition by GPR34.
    2. Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.
      Title: Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.
    3. Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
      Title: Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
    4. G-protein Coupled Receptor 34 Promotes Gliomagenesis by Inducing Proliferation and Malignant Phenotype via TGF-Beta/Smad Signaling Pathway.
      Title: G-protein Coupled Receptor 34 Promotes Gliomagenesis by Inducing Proliferation and Malignant Phenotype via TGF-Beta/Smad Signaling Pathway.
    5. GPR34 activation potentially bridges lymphoepithelial lesions to genesis of salivary gland MALT lymphoma.
      Title: GPR34 activation potentially bridges lymphoepithelial lesions to genesis of salivary gland MALT lymphoma.
    6. G-protein coupled receptor 34 regulates the proliferation and growth of LS174T cells through differential expression of PI3K subunits and PTEN.
      Title: G-protein coupled receptor 34 regulates the proliferation and growth of LS174T cells through differential expression of PI3K subunits and PTEN.
    7. MicroRNA-381 targets G protein-Coupled receptor 34 (GPR34) to regulate the growth, migration and invasion of human cervical cancer cells.
      Title: MicroRNA-381 targets G protein-Coupled receptor 34 (GPR34) to regulate the growth, migration and invasion of human cervical cancer cells.
    8. Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of the Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-Coupled Receptor during Membrane Approach.
      Title: Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of the Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-Coupled Receptor during Membrane Approach.
    9. By monitoring fused FLAG-tag and conformation-sensitive native epitope during expression of GPR34 mutants, a tri-basic motif in the first intracellular loop was identified as key topogenic signal that dictates the orientation of transmembrane domain-1.
      Title: Topogenesis and cell surface trafficking of GPR34 are facilitated by positive-inside rule that effects through a tri-basic motif in the first intracellular loop.
    10. GPR34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro and provides a potential implication for therapy of gastric cancer.
      Title: G-protein coupled receptor 34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of G protein-coupled receptor 34 (GPR34) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 34
    Names
    lysophosphatidylserine receptor 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001097579.2 → NP_001091048.1  probable G-protein coupled receptor 34

      See identical proteins and their annotated locations for NP_001091048.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longer transcript. Both variants 1 and 4 encode the same protein.
      Source sequence(s)
      AK027780, AL627402, BM798913, N40174
      Consensus CDS
      CCDS14258.1
      UniProtKB/Swiss-Prot
      O95853, Q9UPC5
      UniProtKB/TrEMBL
      B3KQM5, B3KVJ9, Q5VT14
      Related
      ENSP00000367384.4, ENST00000378142.9
      Conserved Domains (1) summary
      cd15148
      Location:55 → 338
      7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_005300.4 → NP_005291.1  probable G-protein coupled receptor 34

      See identical proteins and their annotated locations for NP_005291.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Both variants 1 and 4 encode the same protein.
      Source sequence(s)
      AK027780, AW292321, BC020678, H03136
      Consensus CDS
      CCDS14258.1
      UniProtKB/Swiss-Prot
      O95853, Q9UPC5
      UniProtKB/TrEMBL
      B3KQM5, B3KVJ9, Q5VT14
      Related
      ENSP00000367378.5, ENST00000378138.5
      Conserved Domains (1) summary
      cd15148
      Location:55 → 338
      7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      41688973..41697275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272597.5 → XP_005272654.1  probable G-protein coupled receptor 34 isoform X1

      See identical proteins and their annotated locations for XP_005272654.1

      UniProtKB/Swiss-Prot
      O95853, Q9UPC5
      UniProtKB/TrEMBL
      B3KQM5, B3KVJ9, Q5VT14
      Conserved Domains (1) summary
      cd15148
      Location:55 → 338
      7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      41093901..41102205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326884.1 → XP_054182859.1  probable G-protein coupled receptor 34 isoform X1

      UniProtKB/Swiss-Prot
      O95853, Q9UPC5
      UniProtKB/TrEMBL
      Q5VT14

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033513.2: Suppressed sequence

      Description
      NM_001033513.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.

    2. NM_001033514.1: Suppressed sequence

      Description
      NM_001033514.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UPC5.2 GenPept UniProtKB/Swiss-Prot:Q9UPC5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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