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    CCNF cyclin F [ Homo sapiens (human) ]

    Gene ID: 899, updated on 28-Oct-2024

    Summary

    Official Symbol
    CCNFprovided by HGNC
    Official Full Name
    cyclin Fprovided by HGNC
    Primary source
    HGNC:HGNC:1591
    See related
    Ensembl:ENSG00000162063 MIM:600227; AllianceGenome:HGNC:1591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBX1; FBXO1; FTDALS5
    Summary
    This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lymph node (RPKM 3.5), bone marrow (RPKM 2.7) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CCNF in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2429447..2458854)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2451862..2480982)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2479448..2508855)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7042 Neighboring gene ribosomal protein S16 pseudogene 7 Neighboring gene ATP binding cassette subfamily A member 17, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10264 Neighboring gene Sharpr-MPRA regulatory region 3130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2450358-2451105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2472691-2473456 Neighboring gene conserved acetylation island sequence C01 enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2478509-2479088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7045 Neighboring gene uncharacterized LOC105371050 Neighboring gene microRNA 6767 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2508584-2509398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10267 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7049 Neighboring gene TEDC2 antisense RNA 1 Neighboring gene microRNA 6768 Neighboring gene tubulin epsilon and delta complex 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
     
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cyclin-F
    Names
    F-box only protein 1
    G2/mitotic-specific cyclin-F

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001323538.2NP_001310467.1  cyclin-F isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB208829, AC106820, BQ009827, HY027359
      UniProtKB/TrEMBL
      Q59HD0
    2. NM_001761.3NP_001752.2  cyclin-F isoform 1

      See identical proteins and their annotated locations for NP_001752.2

      Status: REVIEWED

      Source sequence(s)
      AB208829, BC012349, DB523776, Z36714
      Consensus CDS
      CCDS10467.1
      UniProtKB/Swiss-Prot
      B2R8H3, P41002, Q96EG9
      UniProtKB/TrEMBL
      Q59HD0
      Related
      ENSP00000380256.4, ENST00000397066.9
      Conserved Domains (5) summary
      smart00256
      Location:3573
      FBOX; A Receptor for Ubiquitination Targets
      COG0790
      Location:88146
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:88112
      SLR; SLR repeat [structural motif]
      pfam00134
      Location:281406
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:421531
      Cyclin_C; Cyclin, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      2429447..2458854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      2451862..2480982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)