TSSK1B testis specific serine kinase 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: TSSK1Bprovided by HGNC
Official Full Name: testis specific serine kinase 1Bprovided by HGNC
Primary source: HGNC:HGNC:14968
See related: Ensembl:ENSG00000212122 MIM:610709; AllianceGenome:HGNC:14968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TSK1; TSSK1; FKSG81; SPOGA4; STK22D
Summary: TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]
Orthologs: mouse all
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Genomic context

Location:: 5q22.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (113432553..113434989, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (113945250..113947686, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (112768250..112770686, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of testisspecific serine kinase 1B in undiagnosed male infertility.
Title: Role of testis‑specific serine kinase 1B in undiagnosed male infertility.
Report evolution of testis-specific kinases TSSK1B and TSSK2 in primates.
Title: Evolution of testis-specific kinases TSSK1B and TSSK2 in primates.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatid development	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatid development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in motile cilium	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: testis-specific serine/threonine-protein kinase 1

Names: TSK-1; TSSK-1; serine/threonine kinase 22D (spermiogenesis associated); serine/threonine kinase FKSG81; serine/threonine-protein kinase 22A; spermiogenesis associated 4; testis tissue sperm-binding protein Li 55e; testis-specific kinase 1; testis-specific serine kinase 1

NP_114417.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032028.4 → NP_114417.1 testis-specific serine/threonine-protein kinase 1

See identical proteins and their annotated locations for NP_114417.1

Status: VALIDATED

Source sequence(s)

AC010431, AK122904, BC022515, DB025324, DB527624

Consensus CDS

CCDS4112.1

UniProtKB/Swiss-Prot

B2R8D9, Q9BXA7

UniProtKB/TrEMBL

A0ZT98

Related

ENSP00000375081.3, ENST00000390666.4

Conserved Domains (1) summary

cd14165
Location:10 → 272

STKc_TSSK1_2-like; Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins