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    EPB41L4A-DT EPB41L4A divergent transcript [ Homo sapiens (human) ]

    Gene ID: 54508, updated on 10-Oct-2023

    Summary

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    Official Symbol
    EPB41L4A-DTprovided by HGNC
    Official Full Name
    EPB41L4A divergent transcriptprovided by HGNC
    Primary source
    HGNC:HGNC:25643
    See related
    Ensembl:ENSG00000278921 AllianceGenome:HGNC:25643
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EPB41L4A-AS2
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    Genomic context

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    See EPB41L4A-DT in Genome Data Viewer
    Location:
    5q22.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (112419583..112420978)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (112930025..112931420)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (111755280..111756675)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein band 4.1 like 4A Neighboring gene uncharacterized LOC124901044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111553293-111553794 Neighboring gene uncharacterized LOC101927023 Neighboring gene NANOG hESC enhancer GRCh37_chr5:111573109-111573620 Neighboring gene NANOG hESC enhancer GRCh37_chr5:111665295-111665825 Neighboring gene Sharpr-MPRA regulatory region 6283 Neighboring gene MPRA-validated peak5419 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111722519-111723020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111723021-111723520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16236 Neighboring gene high mobility group box 3 pseudogene 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111839317-111839816 Neighboring gene uncharacterized LOC124901043 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111858695-111859196

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and validation a TGF-β-associated long non-coding RNA of head and neck squamous cell carcinoma by bioinformatics method. Huang T, et al. J Transl Med, 2018 Feb 28. PMID 29490660, Free PMC Article
    2. The long non-coding RNA EPB41L4A-AS2 inhibits tumor proliferation and is associated with favorable prognoses in breast cancer and other solid tumors. Xu S, et al. Oncotarget, 2016 Apr 12. PMID 26980733, Free PMC Article
    3. Long noncoding RNA EPB41L4A-AS2 inhibits hepatocellular carcinoma development by sponging miR-301a-5p and targeting FOXL1. Wang YG, et al. J Exp Clin Cancer Res, 2019 Apr 10. PMID 30971290, Free PMC Article
    4. Long non-coding RNA EPB41L4A-AS2 suppresses progression of ovarian cancer by sequestering microRNA-103a to upregulate transcription factor RUNX1T1. Sun T, et al. Exp Physiol, 2020 Jan. PMID 31645082
    5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Bennett EJ, et al. Cell, 2010 Dec 10. PMID 21145461, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA EPB41L4A-AS2 suppresses progression of ovarian cancer by sequestering microRNA-103a to upregulate transcription factor RUNX1T1.
      Title: Long non-coding RNA EPB41L4A-AS2 suppresses progression of ovarian cancer by sequestering microRNA-103a to upregulate transcription factor RUNX1T1.
    2. FOXL1 and miR-301a-5p show opposite biological effects in cell proliferation and migration. miR-301a-5p overexpression rescued the EPB41L4A-AS2 upregulation induced depression in proliferation, migration and invasion of HCC cells, as well as promotion effect on FOXL1 expression. In vivo experiments proved that EPB41L4A-AS2 suppress tumor growth and extrahepatic metastasis (lung) via the miR-301a-5p-FOXL1 axis.
      Title: Long noncoding RNA EPB41L4A-AS2 inhibits hepatocellular carcinoma development by sponging miR-301a-5p and targeting FOXL1.
    3. The relationship of EPB41L4A-AS2 with the clinicopathological features and prognosis of head and neck squamous cell carcinoma patients was evaluated.
      Title: Identification and validation a TGF-β-associated long non-coding RNA of head and neck squamous cell carcinoma by bioinformatics method.
    4. Low EPB41L4A-AS2 expression is associated with breast, renal, and lung cancer.
      Title: The long non-coding RNA EPB41L4A-AS2 inhibits tumor proliferation and is associated with favorable prognoses in breast cancer and other solid tumors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • EPB41L4A antisense RNA 2 (head to head)

    Clone Names

    • FLJ11235

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027706.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK002097, BX089466
      Related
      ENST00000623705.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      112419583..112420978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      112930025..112931420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_019033.1: Suppressed sequence

      Description
      NM_019033.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials