MYCBP MYC binding protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: MYCBPprovided by HGNC
Official Full Name: MYC binding proteinprovided by HGNC
Primary source: HGNC:HGNC:7554
See related: Ensembl:ENSG00000214114 MIM:606535; AllianceGenome:HGNC:7554
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AMY-1
Summary: The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]
Expression: Ubiquitous expression in testis (RPKM 11.1), colon (RPKM 10.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p34.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (38862490..38873378, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (38729722..38740619, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (39328162..39339050, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p.
Title: Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p.
MiR-26b-5p inhibits cell proliferation and EMT by targeting MYCBP in triple-negative breast cancer.
Title: MiR-26b-5p inhibits cell proliferation and EMT by targeting MYCBP in triple-negative breast cancer.
TAZ is indispensable for c-MYC-induced hepatocarcinogenesis.
Title: TAZ is indispensable for c-MYC-induced hepatocarcinogenesis.
lncRNA LUNAR1 accelerates colorectal cancer progression by targeting the miR4953p/MYCBP axis.
Title: lncRNA LUNAR1 accelerates colorectal cancer progression by targeting the miR‑495‑3p/MYCBP axis.
Weighted gene co-expression network analysis identifies specific modules and hub genes related to subsyndromal symptomatic depression.
Title: Weighted gene co-expression network analysis identifies specific modules and hub genes related to subsyndromal symptomatic depression.
lnc-XLEC1 had inhibitive effects that may result from its collaboration with MBP-1 (MYCBP).
Title: X chromosome-linked long noncoding RNA lnc-XLEC1 regulates c-Myc-dependent cell growth by collaborating with MBP-1 in endometrial cancer.
Data found that MYCBP was highly expressed in hepatocellular carcinoma (HCC) tissues. Its overexpression is correlated with poor prognosis which indicates that MYCBP might play a cancer-promoting role in HCC. Further results found that EYA4 suppressed HCC tumor cell growth by repressing MYCBP by dephosphorylating beta-catenin S552.
Title: EYA4 inhibits hepatocellular carcinoma by repressing MYCBP by dephosphorylating β-catenin at Ser552.
Through activating MYCBP and by sponging miR-574-5p.
Title: Non-coding RNA MFI2-AS1 promotes colorectal cancer cell proliferation, migration and invasion through miR-574-5p/MYCBP axis.
c-Myc expression is reduced in pterygium compared with normal conjunctiva.
Title: Downregulation of c-Myc in pterygium and cultured pterygial cells.
Suppression of telomerase activity mediated by PinX1 is involved in the Mad1/c-Myc pathway.
Title: PinX1 inhibits telomerase activity in gastric cancer cells through Mad1/c-Myc pathway.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68279 (e-PCR)
- UniSTS:89100

GJA10_965 (e-PCR)
- UniSTS:277281

GJA10_V238 (e-PCR)
- UniSTS:277281

RH65637 (e-PCR)
- UniSTS:86355

RH69866 (e-PCR)
- UniSTS:86142

Readthrough GJA9-MYCBP

Readthrough gene: GJA9-MYCBP, Included gene: GJA9

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-Myc-binding protein

Names: associate of myc-1; c-myc binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012333.5 → NP_036465.2 C-Myc-binding protein

See identical proteins and their annotated locations for NP_036465.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.

Source sequence(s)

AL139260, BC008686, BU601195, CN478752

Consensus CDS

CCDS431.1

UniProtKB/Swiss-Prot

B2R4N0, Q5TA64, Q96HE2, Q99417

UniProtKB/TrEMBL

Q6IB68

Related

ENSP00000380702.2, ENST00000397572.5

Conserved Domains (1) summary

cd21937
Location:42 → 94

ZIP_MycBP-like; leucine zipper domain found in c-Myc-binding protein and similar proteins