OVCA2 OVCA2 serine hydrolase domain containing [Homo sapiens (human)] - Gene

Summary

Official Symbol: OVCA2provided by HGNC
Official Full Name: OVCA2 serine hydrolase domain containingprovided by HGNC
Primary source: HGNC:HGNC:24203
See related: Ensembl:ENSG00000262664 MIM:607896; AllianceGenome:HGNC:24203
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable hydrolase activity. Involved in response to retinoic acid. Located in cytoplasm. Biomarker of ovarian cancer. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal (RPKM 23.0), gall bladder (RPKM 21.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p13.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (2042022..2043425)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (1929929..1931332)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (1945316..1946719)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human OVCA2 and its homolog FSH3-induced apoptosis in Saccharomyces cerevisiae.
Title: Human OVCA2 and its homolog FSH3-induced apoptosis in Saccharomyces cerevisiae.
OVCA2 was confirmed as a serine hydrolase with a strong preference for long-chain alkyl ester substrates (>10-carbons) and high selectivity against a variety of short, branched, and substituted esters, homologous to FSH1 from S. cerevisiae
Title: Comparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae.
is downregulated and degraded during retinoid-induced apoptosis
Title: OVCA2 is downregulated and degraded during retinoid-induced apoptosis.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH18399 (e-PCR)
- UniSTS:7201

WI-14017 (e-PCR)
- UniSTS:51316

G54885 (e-PCR)
- UniSTS:164018

G54886 (e-PCR)
- UniSTS:164019

G54887 (e-PCR)
- UniSTS:164020

G54884 (e-PCR)
- UniSTS:164029

RH78032 (e-PCR)
- UniSTS:13013

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HTP more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: esterase OVCA2

Names: candidate tumor suppressor in ovarian cancer 2; ovarian cancer gene-2 protein; ovarian cancer-associated gene 2 protein; ovarian tumor suppressor candidate 2

NP_543012.1

EC 3.1.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.