KLK13 kallikrein related peptidase 13 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KLK13provided by HGNC
Official Full Name: kallikrein related peptidase 13provided by HGNC
Primary source: HGNC:HGNC:6361
See related: Ensembl:ENSG00000167759 MIM:605505; AllianceGenome:HGNC:6361
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KLKL4; KLK-L4
Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. [provided by RefSeq, Jan 2017]
Expression: Restricted expression toward esophagus (RPKM 227.0) See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.41

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (51055626..51065679, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (54144220..54154419, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (51558883..51568349, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of urinary kallikrein-related peptidase 13 for monitoring bladder cancer.
Title: Analysis of urinary kallikrein-related peptidase 13 for monitoring bladder cancer.
LncRNA WT-AS inhibits metastatic ability of non-small cell lung cancer by regulating KLK13.
Title: LncRNA WT-AS inhibits metastatic ability of non-small cell lung cancer by regulating KLK13.
Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1.
Title: Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1.
serine proteases transmembrane protein serine 11D and kallikrein-related peptidase 13 were shown as active proteases in Cervical-vaginal fluid.
Title: Functional proteomic profiling reveals KLK13 and TMPRSS11D as active proteases in the lower female reproductive tract.
Relatively high levels of KLK13 expression in ESCC were associated with cell proliferation and correlated with tumor progression, advanced cancer stage, and poor prognosis
Title: Expression of kallikrein-related peptidase 13 is associated with poor prognosis in esophageal squamous cell carcinoma.
Decreased KLK13 mRNA levels correlate with poor survival in esophageal squamous cell carcinoma patients.
Title: Downregulation of KLK13 promotes the invasiveness and metastasis of oesophageal squamous cell carcinoma.
There was no significant association of KLK13 and KLK14 mRNA expression with the clinical factors ascitic fluid volume or residual tumor mass. In univariate Cox regression analysis, elevated KLK13 mRNA levels were significantly linked with shorter progression-free (PFS; hazard ratio [HR] = 1.97, P = 0.020) and overall survival (OS; HR = 1.81, P = 0.041).
Title: Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis.
This first clinical study of KLK13 in bladder cancer reveals its deregulated expression in bladder tumors and highlights KLK13 as a promising marker for improving TaT1 patients' prognosis following treatment.
Title: Downregulated KLK13 expression in bladder cancer highlights tumor aggressiveness and unfavorable patients' prognosis.
Our results suggest that KLK13 mRNA expression constitutes a novel biomarker for the prediction of overall survival in nonsmall cell lung cancer and that its quantitative assessment in tumor tissues can aid in treatment decision making.
Title: Kallikrein-related peptidase 13: an independent indicator of favorable prognosis for patients with nonsmall cell lung cancer.
KLK13 may play an important role in regulating cellular migration and invasiveness, making the loss of KLK13 a potential biomarker for early detection of lymph node metastasis in oral squamous cell carcinomas.
Title: Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH92090 (e-PCR)
- UniSTS:88156

NoName (e-PCR)
- UniSTS:480471

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein-13

Names: kallikrein-like gene 4; kallikrein-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348177.2 → NP_001335106.1 kallikrein-13 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AB108824, AC011473, AY923171

Consensus CDS

CCDS86795.1

UniProtKB/TrEMBL

Q86VI7

Related

ENSP00000470245.1, ENST00000595547.5

Conserved Domains (1) summary

cd00190
Location:38 → 188

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001348178.2 → NP_001335107.1 kallikrein-13 isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AB108823, AC011473, AY923171

Consensus CDS

CCDS86794.1

UniProtKB/Swiss-Prot

Q9UKR3

UniProtKB/TrEMBL

Q5BQ99

Related

ENSP00000334079.3, ENST00000335422.3

Conserved Domains (1) summary

cd00190
Location:16 → 109

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_015596.3 → NP_056411.1 kallikrein-13 isoform 1 precursor

See identical proteins and their annotated locations for NP_056411.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC011473, BC069334

Consensus CDS

CCDS12822.1

UniProtKB/Swiss-Prot

A7UNK6, Q86VI8, Q9UKR3, Q9Y433

UniProtKB/TrEMBL

A0A1R3UCE9, B5BUM9

Related

ENSP00000470555.1, ENST00000595793.6

Conserved Domains (1) summary

cd00190
Location:38 → 261

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

NR_145463.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011473, AY923171
NR_145464.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011473, AY923172
NR_145465.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011473, AY923173
NR_145466.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011473, AY923174
NR_145467.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC011473, AY923175