SPOCK1 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SPOCK1provided by HGNC
Official Full Name: SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1provided by HGNC
Primary source: HGNC:HGNC:11251
See related: Ensembl:ENSG00000152377 MIM:602264; AllianceGenome:HGNC:11251
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TIC1; SPOCK; TESTICAN
Summary: This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 74.1), prostate (RPKM 36.6) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q31.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (136975298..137499326, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (137497979..138022024, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (136310987..136835015, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPOCK: Master regulator of malignant tumors (Review).
Title: SPOCK: Master regulator of malignant tumors (Review).
SPOCK1, as a potential prognostic and therapeutic biomarker for lung adenocarcinoma, is associated with epithelial-mesenchymal transition and immune evasion.
Title: SPOCK1, as a potential prognostic and therapeutic biomarker for lung adenocarcinoma, is associated with epithelial-mesenchymal transition and immune evasion.
Knockdown of Long Noncoding RNA Urothelial Carcinoma-Associated 1 Represses Gallbladder Cancer Advancement by Regulating SPOCK1 Expression Through Sponging miR-613.
Title: Knockdown of Long Noncoding RNA Urothelial Carcinoma-Associated 1 Represses Gallbladder Cancer Advancement by Regulating SPOCK1 Expression Through Sponging miR-613.
Proteoglycan SPOCK1 as a Poor Prognostic Marker Promotes Malignant Progression of Clear Cell Renal Cell Carcinoma via Triggering the Snail/Slug-MMP-2 Axis-Mediated Epithelial-to-Mesenchymal Transition.
Title: Proteoglycan SPOCK1 as a Poor Prognostic Marker Promotes Malignant Progression of Clear Cell Renal Cell Carcinoma via Triggering the Snail/Slug-MMP-2 Axis-Mediated Epithelial-to-Mesenchymal Transition.
SPOCK1 and POSTN are valuable prognostic biomarkers and correlate with tumor immune infiltrates in colorectal cancer.
Title: SPOCK1 and POSTN are valuable prognostic biomarkers and correlate with tumor immune infiltrates in colorectal cancer.
SPOCK1 silencing decreases 5-FU resistance through PRRX1 in colorectal cancer.
Title: SPOCK1 silencing decreases 5-FU resistance through PRRX1 in colorectal cancer.
Expression and Potential Prognostic Value of SOX9, MCL-1 and SPOCK1 in Gastric Adenocarcinoma.
Title: Expression and Potential Prognostic Value of SOX9, MCL-1 and SPOCK1 in Gastric Adenocarcinoma.
SPOCK1 promotes metastasis in pancreatic cancer via NF-kappaB-dependent epithelial-mesenchymal transition by interacting with IkappaB-alpha.
Title: SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.
Long non-coding RNA TTN antisense RNA 1 facilitates hepatocellular carcinoma progression via regulating miR-139-5p/SPOCK1 axis.
Title: Long non-coding RNA TTN antisense RNA 1 facilitates hepatocellular carcinoma progression via regulating miR-139-5p/SPOCK1 axis.
SPOCK1 promotes the proliferation and migration of colon cancer cells by regulating the NF-kappaB pathway and inducing EMT.
Title: SPOCK1 promotes the proliferation and migration of colon cancer cells by regulating the NF-κB pathway and inducing EMT.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5S2429 (e-PCR)
- UniSTS:48391

RH102718 (e-PCR)
- UniSTS:97052

D5S2484 (e-PCR)
- UniSTS:68383

SHGC-106775 (e-PCR)
- UniSTS:170015

bac5202S (e-PCR)
- UniSTS:181541

bac5202T (e-PCR)
- UniSTS:181542

bac5208S (e-PCR)
- UniSTS:181548

D5S2225E (e-PCR)
- UniSTS:154431

IB3085 (e-PCR)
- UniSTS:30528

SHGC-85172 (e-PCR)
- UniSTS:104018

RH120820 (e-PCR)
- UniSTS:133473

RH123614 (e-PCR)
- UniSTS:136033

1446 (e-PCR)
- UniSTS:45161

RH123159 (e-PCR)
- UniSTS:135540

SHGC-66131 (e-PCR)
- UniSTS:184207

SHGC-78948 (e-PCR)
- UniSTS:184219

L31473 (e-PCR)
- UniSTS:50588

SHGC-146899 (e-PCR)
- UniSTS:172711

A002R29 (e-PCR)
- UniSTS:42179

RH103418 (e-PCR)
- UniSTS:97743

SHGC-78900 (e-PCR)
- UniSTS:100852

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in central nervous system neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	NAS Non-traceable Author Statement more info	PubMed
involved_in neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell growth	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	ISS Inferred from Sequence or Structural Similarity more info
located_in node of Ranvier	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density	NAS Non-traceable Author Statement more info	PubMed
located_in sarcoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: testican-1

Names: SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1; sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_034127.1 RefSeqGene

Range

5004..529032

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004598.4 → NP_004589.1 testican-1 precursor

See identical proteins and their annotated locations for NP_004589.1

Status: REVIEWED

Source sequence(s)

AC005213, AF231124, BC030691, BI550122

Consensus CDS

CCDS4191.1

UniProtKB/Swiss-Prot

B3KSW3, Q08629, Q59EW0, Q8N630, Q9UCL8

Related

ENSP00000378401.1, ENST00000394945.6

Conserved Domains (4) summary

cd00191
Location:312 → 372

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

cd00252
Location:197 → 315

SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...

pfam07648
Location:139 → 178

Kazal_2; Kazal-type serine protease inhibitor domain

pfam10591
Location:196 → 302

SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region