U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CCPG1 cell cycle progression 1 [ Homo sapiens (human) ]

    Gene ID: 9236, updated on 14-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CCPG1provided by HGNC
    Official Full Name
    cell cycle progression 1provided by HGNC
    Primary source
    HGNC:HGNC:24227
    See related
    Ensembl:ENSG00000260916 MIM:611326; AllianceGenome:HGNC:24227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPR8
    Summary
    Involved in positive regulation of cell cycle and positive regulation of cell population proliferation. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 34.7), gall bladder (RPKM 22.2) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CCPG1 in Genome Data Viewer
    Location:
    15q21.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (55355239..55408359, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (53158427..53211591, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (55647437..55700557, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9439 Neighboring gene RAB27A, member RAS oncogene family Neighboring gene Sharpr-MPRA regulatory region 6285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9444 Neighboring gene PIGB opposite strand 1 Neighboring gene NANOG hESC enhancer GRCh37_chr15:55644998-55645641 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class B Neighboring gene DNAAF4-CCPG1 readthrough (NMD candidate) Neighboring gene ReSE screen-validated silencer GRCh37_chr15:55674784-55674963 Neighboring gene microRNA 628 Neighboring gene Sharpr-MPRA regulatory region 6559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9447 Neighboring gene piercer of microtubule wall 2 Neighboring gene thioesterase superfamily member 4 pseudogene Neighboring gene dynein axonemal assembly factor 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Clinical and prognostic significance of CCPG1 in hepatocellular carcinoma. Wang G, et al. Gen Physiol Biophys, 2023 Sep. PMID 37702448
    2. RNAi screen indicates widespread biological function for human natural antisense transcripts. Faghihi MA, et al. PLoS One, 2010 Oct 4. PMID 20957177, Free PMC Article
    3. CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis. Smith MD, et al. Dev Cell, 2018 Jan 22. PMID 29290589, Free PMC Article
    4. A genome scale location analysis of human Staf/ZNF143-binding sites suggests a widespread role for human Staf/ZNF143 in mammalian promoters. Myslinski E, et al. J Biol Chem, 2006 Dec 29. PMID 17092945
    5. Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. Edwards MC, et al. Genetics, 1997 Nov. PMID 9383053, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Readthrough DNAAF4-CCPG1

    Readthrough gene: DNAAF4-CCPG1, Included gene: DNAAF4

    Homology

    Clone Names

    • FLJ60574, KIAA1254

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cell cycle progression protein 1
    Names
    cell cycle progression restoration protein 8

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204450.2 → NP_001191379.1  cell cycle progression protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001191379.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a segment in the 3' coding region that results in a frameshift. The encoded isoform (2) has a distinct and longer C-terminus, compared to isoform 1.
      Source sequence(s)
      AA740595, AC018926, AK292795, DB084778
      Consensus CDS
      CCDS55966.1
      UniProtKB/Swiss-Prot
      Q9ULG6
      Related
      ENSP00000403400.3, ENST00000442196.8
      Conserved Domains (1) summary
      pfam05837
      Location:313 → 401
      CENP-H; Centromere protein H (CENP-H)

    2. NM_001204451.2 → NP_001191380.1  cell cycle progression protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001191380.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two segments in the 3' coding region, one of which causes a frameshift. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA740595, AC018926, AK022459, DB084778
      Consensus CDS
      CCDS55967.1
      UniProtKB/Swiss-Prot
      Q9ULG6
      Related
      ENSP00000415128.3, ENST00000425574.7
      Conserved Domains (2) summary
      PLN02328
      Location:84 → 231
      PLN02328; lysine-specific histone demethylase 1 homolog
      pfam04375
      Location:195 → 321
      HemX; HemX

    3. NM_004748.6 → NP_004739.3  cell cycle progression protein 1 isoform 1

      See identical proteins and their annotated locations for NP_004739.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AA740595, AC018926, BC039871, DA670725, DA720583
      Consensus CDS
      CCDS42039.1
      UniProtKB/Swiss-Prot
      A0PJH3, A8K9T0, O14712, Q05DG4, Q5U5S7, Q8IYV8, Q9BY53, Q9HA17, Q9ULG6
      Related
      ENSP00000454456.1, ENST00000569205.5
      Conserved Domains (1) summary
      pfam05837
      Location:313 → 401
      CENP-H; Centromere protein H (CENP-H)

    4. NM_020739.5 → NP_065790.2  cell cycle progression protein 1 isoform 1

      See identical proteins and their annotated locations for NP_065790.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AA740595, AC018926, BC039871, DB084778
      Consensus CDS
      CCDS42039.1
      UniProtKB/Swiss-Prot
      A0PJH3, A8K9T0, O14712, Q05DG4, Q5U5S7, Q8IYV8, Q9BY53, Q9HA17, Q9ULG6
      Related
      ENSP00000311656.6, ENST00000310958.10
      Conserved Domains (1) summary
      pfam05837
      Location:313 → 401
      CENP-H; Centromere protein H (CENP-H)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      55355239..55408359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      53158427..53211591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULG6.3 GenPept UniProtKB/Swiss-Prot:Q9ULG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools