SSU72 SSU72 homolog, RNA polymerase II CTD phosphatase [Homo sapiens (human)] - Gene

Summary

Official Symbol: SSU72provided by HGNC
Official Full Name: SSU72 homolog, RNA polymerase II CTD phosphataseprovided by HGNC
Primary source: HGNC:HGNC:25016
See related: Ensembl:ENSG00000160075 MIM:617680; AllianceGenome:HGNC:25016
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSPC182; PNAS-120
Summary: Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Involved in dephosphorylation of RNA polymerase II C-terminal domain and mRNA polyadenylation. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thyroid (RPKM 50.5), fat (RPKM 49.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.33

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (1541673..1574863, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (976177..1009369, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (1477053..1510243, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diverse and conserved roles of the protein Ssu72 in eukaryotes: from yeast to higher organisms.
Title: Diverse and conserved roles of the protein Ssu72 in eukaryotes: from yeast to higher organisms.
Ssu72 Dual-Specific Protein Phosphatase: From Gene to Diseases.
Title: Ssu72 Dual-Specific Protein Phosphatase: From Gene to Diseases.
results demonstrate when Ssu72 can act on early transcription complexes and suggest that Ssu72 may also function in thepreinitiation complex prior to initiation.
Title: Functional interaction of human Ssu72 with RNA polymerase II complexes.
a hand-off model in which Ssu72 mediates a conformational transition in TFIIB, accounting for the role of Ssu72 in transcription reinitiation, gene looping, and promoter-terminator cross-talk.
Title: Structural dissection of an interaction between transcription initiation and termination factors implicated in promoter-terminator cross-talk.
Aurora B kinase directly targets Ssu72 phosphatase for regulation of sister chromatid cohesion during early mitosis.
Title: Functional interplay between Aurora B kinase and Ssu72 phosphatase regulates sister chromatid cohesion.
The pSer7 phosphatase activity of Ssu72 is approximately 4000-fold lower than its pSer5 phosphatase activity toward a peptide substrate
Title: An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72.
Data suggest that Ssu72 is a novel cohesin-binding protein capable of regulating cohesion between sister chromatid arms.
Title: The hsSsu72 phosphatase is a cohesin-binding protein that regulates the resolution of sister chromatid arm cohesion.
crystal structure at 2.4 A resolution of the amino-terminal domain (residues 30-340) of human symplekin in a ternary complex with the Pol II carboxy-terminal domain (CTD) Ser 5 phosphatase Ssu72 and a CTD Ser 5 phosphopeptide
Title: Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Observational study of gene-disease association. (HuGE Navigator)
Title: High resolution linkage and linkage disequilibrium analyses of chromosome 1p36 SNPs identify new positional candidate genes for low bone mineral density.
Molecular cloning and characterization of functions of human ssu72.
Title: Conserved and specific functions of mammalian ssu72.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of SSU72 RNA polymerase II CTD phosphatase homolog by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat recruits Ssu72 together with P-TEFb to the integrated HIV-1 proviral promoter in TNF-alpha treated 2D10 T cells	PubMed
	tat	Ssu72 cooperates with the Tat/P-TEFb complex to create a CTD that is highly enriched in S2 phosphorylation	PubMed
	tat	Ssu72 stimulates HIV-1 Tat transactivation in a C-terminal domain phosphatase-dependent manner	PubMed
	tat	HIV-1 Tat interacts directly with the human Ssu72 CTD phosphatase and both the N-terminal and the C-terminal domains of Tat, and the coiled-coil domain of Ssu72 are required for the direct interaction between Tat and Ssu72	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:434012 (e-PCR)
- UniSTS:157204

SHGC-74075 (e-PCR)
- UniSTS:25923

GDB:314949 (e-PCR)
- UniSTS:156503

SHGC-74090 (e-PCR)
- UniSTS:20856

A009A39 (e-PCR)
- UniSTS:82566

STS-Z40614 (e-PCR)
- UniSTS:25743

Fc.estTEB11 (e-PCR)
- UniSTS:266901

WI-17614 (e-PCR)
- UniSTS:12722

A001Y42 (e-PCR)
- UniSTS:18376

RH70327 (e-PCR)
- UniSTS:65523

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in termination of RNA polymerase II transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
part_of mRNA cleavage and polyadenylation specificity factor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Names: CTD phosphatase SSU72

NP_054907.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.