DCANP1 dendritic cell associated nuclear protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DCANP1provided by HGNC
Official Full Name: dendritic cell associated nuclear protein 1provided by HGNC
Primary source: HGNC:HGNC:24459
See related: Ensembl:ENSG00000251380 MIM:609710; AllianceGenome:HGNC:24459
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DCNP1; C5orf20
Summary: This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans. [provided by RefSeq, Jul 2008]
Orthologs: all
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Genomic context

Location:: 5q31.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (135444214..135447348, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (135971385..135974519, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (134779904..134783038, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our study reveals a connection between the major depression candidate protein DCNP1, circadian system and melatonin biosynthesis, which may contribute to the pathogenesis of depression.
Title: Dendritic cell nuclear protein-1 regulates melatonin biosynthesis by binding to BMAL1 and inhibiting the transcription of N-acetyltransferase in C6 cells.
In the Han Chinese population, common DCNP1 polymorphisms are unlikely to be important in the genetic susceptibility to MDD.
Title: Lack of association between dendritic cell nuclear protein-1 gene and major depressive disorder in the Han Chinese population.
We propose that full-length dendritic cell nucleus protein-1 may play a role in the pathogenesis of depressive disorders by enhancing corticotropin-releasing hormone expression in the hypothalamic paraventricular nucleus.
Title: Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression.
Observational study of gene-disease association. (HuGE Navigator)
Title: Poor replication of candidate genes for major depressive disorder using genome-wide association data.
the genetic polymorphism of DCNP1 may influence production of specific IgE by altering DC (Dendritic Cells)functions in the mite allergen presenting and/or processing.
Title: A promoter nucleotide variant of the dendritic cell-specific DCNP1 associates with serum IgE levels specific for dust mite allergens among the Korean asthmatics.
molecular cloning and immunocytochemical analysis
Title: Identification and immunocytochemical analysis of DCNP1, a dendritic cell-associated nuclear protein.
Marker rs12520799, in dendritic cell nuclear protein 1 on chromosome 5, yielded a significant association with lifetime major depression.
Title: DCNP1: a novel candidate gene for major depression.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482053

RH93048 (e-PCR)
- UniSTS:85013

NoName (e-PCR)
- UniSTS:480796

NoName (e-PCR)
- UniSTS:485969

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in auditory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cochlea development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cochlea morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in craniofacial suture morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in genitalia development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in genitalia morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hard palate morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inner ear development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inner ear morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in learned vocalization behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mastication	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of relaxation of muscle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of saliva secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuromuscular process controlling balance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peristalsis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of muscle organ development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thorax and anterior abdomen determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in trigeminal nerve development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vestibulocochlear nerve formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: dendritic cell nuclear protein 1

Names: dendritic cell-associated nuclear protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.