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    SCARA5 scavenger receptor class A member 5 [ Homo sapiens (human) ]

    Gene ID: 286133, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SCARA5provided by HGNC
    Official Full Name
    scavenger receptor class A member 5provided by HGNC
    Primary source
    HGNC:HGNC:28701
    See related
    Ensembl:ENSG00000168079 MIM:611306; AllianceGenome:HGNC:28701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Tesr; NET33
    Summary
    Predicted to enable ferritin receptor activity. Predicted to be involved in several processes, including intracellular iron ion homeostasis; iron ion transmembrane transport; and protein homotrimerization. Predicted to act upstream of or within cellular response to heat. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in fat (RPKM 25.7), colon (RPKM 18.6) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SCARA5 in Genome Data Viewer
    Location:
    8p21.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (27869883..27992673, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (28147213..28270893, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27727400..27850190, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene MPRA-validated peak6971 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27158 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa pseudogene Neighboring gene PDZ binding kinase Neighboring gene SCARA5 intron CAGE-defined high expression enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27735141-27735642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27750341-27750927 Neighboring gene VISTA enhancer hs1741 Neighboring gene uncharacterized LOC105379342 Neighboring gene microRNA 4287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27806885-27807386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27807387-27807886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27834121-27835005 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:27918038-27918203 Neighboring gene nuclear GTPase, germinal center associated Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27920879-27921378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27160 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:27950237-27950790 Neighboring gene MPRA-validated peak6972 silencer Neighboring gene elongator acetyltransferase complex subunit 3 Neighboring gene uncharacterized LOC105379343

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Methylated tumor suppressor gene SCARA5 inhibits the proliferation, migration and invasion of nasopharyngeal carcinoma. Jiang X, et al. Epigenomics, 2023 Jun. PMID 37554122
    2. Scavenger receptor class A, member 5 is associated with thyroid cancer cell lines progression via epithelial-mesenchymal transition. Zheng C, et al. Cell Biochem Funct, 2020 Mar. PMID 31989658, Free PMC Article
    3. The scavenger receptor SCARA5 is an endocytic receptor for von Willebrand factor expressed by littoral cells in the human spleen. Swystun LL, et al. J Thromb Haemost, 2019 Aug. PMID 31126000, Free PMC Article
    4. Downregulation of SCARA5 may contribute to breast cancer via promoter hypermethylation. Ulker D, et al. Gene, 2018 Oct 5. PMID 29908284
    5. Identification of SCARA5 as a Potential Biomarker for Oral Squamous Cell Carcinoma using MALDI-TOF-MS Analysis. Liu Y, et al. Proteomics Clin Appl, 2018 Sep. PMID 29461673

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCARA5 as a downstream factor of PCAT29, inhibits proliferation, migration, and invasion of bladder cancer.
      Title: SCARA5 as a downstream factor of PCAT29, inhibits proliferation, migration, and invasion of bladder cancer.
    2. m[6]A-mediated upregulation of lncRNA RMRP boosts the progression of bladder cancer via epigenetically suppressing SCARA5.
      Title: m(6)A-mediated upregulation of lncRNA RMRP boosts the progression of bladder cancer via epigenetically suppressing SCARA5.
    3. Methylated tumor suppressor gene SCARA5 inhibits the proliferation, migration and invasion of nasopharyngeal carcinoma.
      Title: Methylated tumor suppressor gene SCARA5 inhibits the proliferation, migration and invasion of nasopharyngeal carcinoma.
    4. SCARA5 induced ferroptosis to effect ESCC proliferation and metastasis by combining with Ferritin light chain.
      Title: SCARA5 induced ferroptosis to effect ESCC proliferation and metastasis by combining with Ferritin light chain.
    5. Highly Expressing SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma.
      Title: Highly Expressing SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma.
    6. Tumor suppressive effect of scavenger receptor class A member 5 overexpression in colorectal cancer by regulating PI3K/AKT/mTOR pathway.
      Title: Tumor suppressive effect of scavenger receptor class A member 5 overexpression in colorectal cancer by regulating PI3K/AKT/mTOR pathway.
    7. SCARA5 is a Novel Biomarker in Colorectal Cancer by Comprehensive Analysis.
      Title: SCARA5 is a Novel Biomarker in Colorectal Cancer by Comprehensive Analysis.
    8. SCARA5 suppresses the proliferation and migration, and promotes the apoptosis of human retinoblastoma cells by inhibiting the PI3K/AKT pathway.
      Title: SCARA5 suppresses the proliferation and migration, and promotes the apoptosis of human retinoblastoma cells by inhibiting the PI3K/AKT pathway.
    9. Interactions of ferritin with scavenger receptor class A members.
      Title: Interactions of ferritin with scavenger receptor class A members.
    10. Scavenger receptor class A, member 5 is associated with thyroid cancer cell lines progression via epithelial-mesenchymal transition.
      Title: Scavenger receptor class A, member 5 is associated with thyroid cancer cell lines progression via epithelial-mesenchymal transition.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23907, MGC45780

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ferritin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular iron ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in iron ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homotrimerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    scavenger receptor class A member 5
    Names
    scavenger receptor class A, member 5 (putative)
    scavenger receptor hlg
    testis expressed scavenger receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413201.1 → NP_001400130.1  scavenger receptor class A member 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC069113, AC104997

    2. NM_001413202.1 → NP_001400131.1  scavenger receptor class A member 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC069113
      Related
      ENSP00000428663.1, ENST00000524352.5

    3. NM_001413203.1 → NP_001400132.1  scavenger receptor class A member 5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC069113, AC104997

    4. NM_173833.6 → NP_776194.2  scavenger receptor class A member 5 isoform 1

      See identical proteins and their annotated locations for NP_776194.2

      Status: VALIDATED

      Source sequence(s)
      AC069113, AC104997
      Consensus CDS
      CCDS6064.1
      UniProtKB/Swiss-Prot
      Q6UXZ1, Q6ZMJ2, Q7Z4A1, Q8N4Z7
      Related
      ENSP00000346990.3, ENST00000354914.8
      Conserved Domains (3) summary
      smart00202
      Location:393 → 493
      SR; Scavenger receptor Cys-rich
      pfam01391
      Location:318 → 373
      Collagen; Collagen triple helix repeat (20 copies)
      pfam12795
      Location:89 → 191
      MscS_porin; Mechanosensitive ion channel porin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      27869883..27992673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      28147213..28270893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZMJ2.1 GenPept UniProtKB/Swiss-Prot:Q6ZMJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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