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    DDR1 discoidin domain receptor tyrosine kinase 1 [ Homo sapiens (human) ]

    Gene ID: 780, updated on 11-Apr-2024

    Summary

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    Official Symbol
    DDR1provided by HGNC
    Official Full Name
    discoidin domain receptor tyrosine kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:2730
    See related
    Ensembl:ENSG00000204580 MIM:600408; AllianceGenome:HGNC:2730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A
    Summary
    Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in brain (RPKM 49.5), thyroid (RPKM 24.8) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DDR1 in Genome Data Viewer
    Location:
    6p21.33
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30880970..30900156)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30745627..30764828)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30848747..30867933)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr6:30808614-30808790 Neighboring gene long intergenic non-protein coding RNA 2570 Neighboring gene Sharpr-MPRA regulatory region 587 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30814964-30815466 Neighboring gene Sharpr-MPRA regulatory region 13207 Neighboring gene RN7SK pseudogene 186 Neighboring gene NANOG hESC enhancer GRCh37_chr6:30845201-30845702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30848468-30849396 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30851831-30852604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30852674-30853181 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30854197-30854703 Neighboring gene microRNA 4640 Neighboring gene general transcription factor IIH subunit 4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:30889690-30890889 Neighboring gene valyl-tRNA synthetase 2, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression. Xiong YX, et al. Cell Death Differ, 2023 Jul. PMID 37117273,
    2. DDR1 and Its Ligand, Collagen IV, Are Involved in In Vitro Oligodendrocyte Maturation. Silva ME, et al. Int J Mol Sci, 2023 Jan 16. PMID 36675255, Free PMC Article
    3. DDR1 functions as an immune negative factor in colorectal cancer by regulating tumor-infiltrating T cells through IL-18. Duan X, et al. Cancer Sci, 2022 Nov. PMID 35969377, Free PMC Article
    4. Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen-Induced Apoptosis in Rhabdomyosarcoma Cells. Gonzalez-Molina J, et al. Adv Sci (Weinh), 2022 Oct. PMID 35957513, Free PMC Article
    5. Discoidin domain receptor 1 is a potential target correlated with tumor invasion and immune infiltration in gastric cancer. Wang S, et al. Front Immunol, 2022. PMID 35935941, Free PMC Article

    See all (222) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder.
      Title: Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder.
    2. Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1) Is a Novel Therapeutic Target in Liposarcoma: A Tissue Microarray Study.
      Title: Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1) Is a Novel Therapeutic Target in Liposarcoma: A Tissue Microarray Study.
    3. DDR1-Induced Paracrine Factors of Hepatocytes Promote HSC Activation and Fibrosis Development.
      Title: DDR1-Induced Paracrine Factors of Hepatocytes Promote HSC Activation and Fibrosis Development.
    4. Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression.
      Title: Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression.
    5. Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer.
      Title: Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer.
    6. DDR1 and Its Ligand, Collagen IV, Are Involved in In Vitro Oligodendrocyte Maturation.
      Title: DDR1 and Its Ligand, Collagen IV, Are Involved in In Vitro Oligodendrocyte Maturation.
    7. DDR1 functions as an immune negative factor in colorectal cancer by regulating tumor-infiltrating T cells through IL-18.
      Title: DDR1 functions as an immune negative factor in colorectal cancer by regulating tumor-infiltrating T cells through IL-18.
    8. DDR1 promotes LoVo cell proliferation by regulating energy metabolism.
      Title: DDR1 promotes LoVo cell proliferation by regulating energy metabolism.
    9. Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen-Induced Apoptosis in Rhabdomyosarcoma Cells.
      Title: Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen-Induced Apoptosis in Rhabdomyosarcoma Cells.
    10. Discoidin domain receptor 1(DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis.
      Title: Discoidin domain receptor 1(DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis.
    Submit: New GeneRIF Correction See all GeneRIFs (160)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variation and the control of HIV-1 in humans.
    EBI GWAS Catalog
    Genetic predictors of medically refractory ulcerative colitis.
    EBI GWAS Catalog
    Seven new loci associated with age-related macular degeneration.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables collagen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables collagen binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase collagen receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase collagen receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in branching involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in collagen-activated tyrosine kinase receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ear development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo implantation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mammary gland alveolus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron projection extension IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-tyrosine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in smooth muscle cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing, spreading of cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    epithelial discoidin domain-containing receptor 1
    Names
    CD167 antigen-like family member A
    PTK3A protein tyrosine kinase 3A
    cell adhesion kinase
    mammary carcinoma kinase 10
    neuroepithelial tyrosine kinase
    neurotrophic tyrosine kinase, receptor, type 4
    protein-tyrosine kinase RTK-6
    tyrosine kinase DDR
    tyrosine-protein kinase CAK
    NP_001189450.1
    NP_001189451.1
    NP_001189452.2
    NP_001284581.1
    NP_001284582.1
    NP_001284583.1
    NP_001374821.1
    NP_001374822.1
    NP_001374823.1
    NP_001374824.1
    NP_001374825.1
    NP_001374826.1
    NP_001374827.1
    NP_001374828.1
    NP_001374829.1
    NP_001374830.1
    NP_001374831.1
    NP_001374832.1
    NP_001374833.1
    NP_001374834.1
    NP_001374835.1
    NP_001374836.1
    NP_001374837.1
    NP_001374838.1
    NP_001374839.1
    NP_001374840.1
    NP_001374841.1
    NP_001374842.1
    NP_001374843.1
    NP_001374844.1
    NP_001374845.1
    NP_001374846.1
    NP_001374847.1
    NP_001397798.1
    NP_001945.3
    NP_054699.2
    NP_054700.2
    XP_011513186.1
    XP_011513189.1
    XP_016866757.1
    XP_024302308.1
    XP_024302309.1
    XP_047275274.1
    XP_047275275.1
    XP_047275276.1
    XP_047275277.1
    XP_047275278.1
    XP_047275279.1
    XP_047275280.1
    XP_047275281.1
    XP_047275282.1
    XP_047275283.1
    XP_047275284.1
    XP_047275285.1
    XP_047275286.1
    XP_047275287.1
    XP_047275288.1
    XP_047275289.1
    XP_054185845.1
    XP_054185846.1
    XP_054185847.1
    XP_054185848.1
    XP_054185849.1
    XP_054185850.1
    XP_054185851.1
    XP_054185852.1
    XP_054185853.1
    XP_054185854.1
    XP_054185855.1
    XP_054185856.1
    XP_054186331.1
    XP_054186332.1
    XP_054186333.1
    XP_054186334.1
    XP_054186335.1
    XP_054186336.1
    XP_054186337.1
    XP_054186338.1
    XP_054186339.1
    XP_054186340.1
    XP_054186341.1
    XP_054186342.1
    XP_054186343.1
    XP_054186344.1
    XP_054186345.1
    XP_054186346.1
    XP_054186347.1
    XP_054186608.1
    XP_054186609.1
    XP_054186610.1
    XP_054186611.1
    XP_054186612.1
    XP_054186613.1
    XP_054186614.1
    XP_054186615.1
    XP_054186616.1
    XP_054186617.1
    XP_054186618.1
    XP_054186619.1
    XP_054186620.1
    XP_054186621.1
    XP_054186622.1
    XP_054186623.1
    XP_054186624.1
    XP_054186625.1
    XP_054186626.1
    XP_054187105.1
    XP_054187106.1
    XP_054187107.1
    XP_054187108.1
    XP_054187109.1
    XP_054187110.1
    XP_054187111.1
    XP_054187112.1
    XP_054187113.1
    XP_054187114.1
    XP_054187115.1
    XP_054187116.1
    XP_054187117.1
    XP_054187118.1
    XP_054187119.1
    XP_054187120.1
    XP_054187121.1
    XP_054187122.1
    XP_054187123.1
    XP_054212333.1
    XP_054212334.1
    XP_054212335.1
    XP_054212336.1
    XP_054212337.1
    XP_054212338.1
    XP_054212339.1
    XP_054212340.1
    XP_054212341.1
    XP_054212342.1
    XP_054212343.1
    XP_054212344.1
    XP_054212345.1
    XP_054212346.1
    XP_054212347.1
    XP_054212348.1
    XP_054212349.1
    XP_054212350.1
    XP_054212351.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029066.1 RefSeqGene

      Range
      5436..21073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202521.1 → NP_001189450.1  epithelial discoidin domain-containing receptor 1 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AF353182, BC008716, L20817
      UniProtKB/Swiss-Prot
      Q08345
      UniProtKB/TrEMBL
      Q96T62
      Conserved Domains (2) summary
      smart00231
      Location:30 → 185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    2. NM_001202522.1 → NP_001189451.1  epithelial discoidin domain-containing receptor 1 isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AF353183, BC008716, L20817
      Consensus CDS
      CCDS75419.1
      UniProtKB/TrEMBL
      A0A0A0MSX3, A0A0G2JNZ7
      Related
      ENSP00000405998.2, ENST00000446312.5
      Conserved Domains (2) summary
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl21453
      Location:478 → 761
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001202523.3 → NP_001189452.2  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    4. NM_001297652.2 → NP_001284581.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001284581.1

      Status: REVIEWED

      Source sequence(s)
      AK291621, AK294793, BC008716, DA461082
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Related
      ENSP00000407699.2, ENST00000418800.6
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    5. NM_001297653.2 → NP_001284582.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001284582.1

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    6. NM_001297654.2 → NP_001284583.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001284583.1

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Related
      ENSP00000365752.3, ENST00000376568.8
      Conserved Domains (2) summary
      cd05096
      Location:604 → 907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    7. NM_001387892.1 → NP_001374821.1  epithelial discoidin domain-containing receptor 1 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS47396.1
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Related
      ENSP00000427552.1, ENST00000513240.5
      Conserved Domains (2) summary
      cd05096
      Location:604 → 913
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    8. NM_001387893.1 → NP_001374822.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    9. NM_001387894.1 → NP_001374823.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    10. NM_001387895.1 → NP_001374824.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    11. NM_001387896.1 → NP_001374825.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    12. NM_001387897.1 → NP_001374826.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    13. NM_001387898.1 → NP_001374827.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    14. NM_001387899.1 → NP_001374828.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    15. NM_001387900.1 → NP_001374829.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    16. NM_001387901.1 → NP_001374830.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    17. NM_001387902.1 → NP_001374831.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    18. NM_001387903.1 → NP_001374832.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    19. NM_001387904.1 → NP_001374833.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    20. NM_001387905.1 → NP_001374834.1  epithelial discoidin domain-containing receptor 1 isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 876
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    21. NM_001387906.1 → NP_001374835.1  epithelial discoidin domain-containing receptor 1 isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 876
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    22. NM_001387907.1 → NP_001374836.1  epithelial discoidin domain-containing receptor 1 isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 876
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    23. NM_001387908.1 → NP_001374837.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    24. NM_001387909.1 → NP_001374838.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    25. NM_001387910.1 → NP_001374839.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    26. NM_001387911.1 → NP_001374840.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    27. NM_001387912.1 → NP_001374841.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    28. NM_001387913.1 → NP_001374842.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    29. NM_001387914.1 → NP_001374843.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Related
      ENSP00000365753.3, ENST00000376569.7
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    30. NM_001387915.1 → NP_001374844.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    31. NM_001387916.1 → NP_001374845.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    32. NM_001387917.1 → NP_001374846.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    33. NM_001387918.1 → NP_001374847.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    34. NM_001410869.1 → NP_001397798.1  epithelial discoidin domain-containing receptor 1 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS93879.1
      Related
      ENSP00000422442.1, ENST00000508312.5

    35. NM_001954.5 → NP_001945.3  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001945.3

      Status: REVIEWED

      Source sequence(s)
      BC008716, BC070070
      Consensus CDS
      CCDS4690.1
      UniProtKB/TrEMBL
      A0A024RCQ1, A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Related
      ENSP00000365754.4, ENST00000376570.8
      Conserved Domains (2) summary
      cd05096
      Location:567 → 870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    36. NM_013993.3 → NP_054699.2  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_054699.2

      Status: REVIEWED

      Source sequence(s)
      AL662870, BC008716, CN362335, L11315
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      B5A975, B5A976, B7Z2K0, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Related
      ENSP00000405039.1, ENST00000452441.5
      Conserved Domains (2) summary
      cd05096
      Location:604 → 907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    37. NM_013994.3 → NP_054700.2  epithelial discoidin domain-containing receptor 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_054700.2

      Status: REVIEWED

      Source sequence(s)
      AL662870
      Consensus CDS
      CCDS47396.1
      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 913
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      30880970..30900156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419324.1 → XP_047275280.1  epithelial discoidin domain-containing receptor 1 isoform X1

    2. XM_011514884.2 → XP_011513186.1  epithelial discoidin domain-containing receptor 1 isoform X5

      See identical proteins and their annotated locations for XP_011513186.1

      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 913
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    3. XM_011514887.3 → XP_011513189.1  epithelial discoidin domain-containing receptor 1 isoform X5

      See identical proteins and their annotated locations for XP_011513189.1

      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 913
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    4. XM_047419329.1 → XP_047275285.1  epithelial discoidin domain-containing receptor 1 isoform X5

    5. XM_047419318.1 → XP_047275274.1  epithelial discoidin domain-containing receptor 1 isoform X1

    6. XM_024446541.2 → XP_024302309.1  epithelial discoidin domain-containing receptor 1 isoform X5

      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 913
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    7. XM_047419321.1 → XP_047275277.1  epithelial discoidin domain-containing receptor 1 isoform X1

    8. XM_047419322.1 → XP_047275278.1  epithelial discoidin domain-containing receptor 1 isoform X1

    9. XM_047419320.1 → XP_047275276.1  epithelial discoidin domain-containing receptor 1 isoform X1

    10. XM_047419319.1 → XP_047275275.1  epithelial discoidin domain-containing receptor 1 isoform X1

    11. XM_047419326.1 → XP_047275282.1  epithelial discoidin domain-containing receptor 1 isoform X2

    12. XM_047419333.1 → XP_047275289.1  epithelial discoidin domain-containing receptor 1 isoform X3

    13. XM_017011268.3 → XP_016866757.1  epithelial discoidin domain-containing receptor 1 isoform X5

      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 913
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    14. XM_047419323.1 → XP_047275279.1  epithelial discoidin domain-containing receptor 1 isoform X1

    15. XM_047419330.1 → XP_047275286.1  epithelial discoidin domain-containing receptor 1 isoform X5

    16. XM_047419328.1 → XP_047275284.1  epithelial discoidin domain-containing receptor 1 isoform X5

    17. XM_047419325.1 → XP_047275281.1  epithelial discoidin domain-containing receptor 1 isoform X2

    18. XM_047419331.1 → XP_047275287.1  epithelial discoidin domain-containing receptor 1 isoform X4

    19. XM_047419332.1 → XP_047275288.1  epithelial discoidin domain-containing receptor 1 isoform X3

    20. XM_024446540.2 → XP_024302308.1  epithelial discoidin domain-containing receptor 1 isoform X5

      UniProtKB/TrEMBL
      A0A1U9X7K3, A0A1U9X7L5, A0A1U9X7M1
      Conserved Domains (2) summary
      cd05096
      Location:604 → 913
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60 → 184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    21. XM_047419327.1 → XP_047275283.1  epithelial discoidin domain-containing receptor 1 isoform X5

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      2214565..2218962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      2360739..2379927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329873.1 → XP_054185848.1  epithelial discoidin domain-containing receptor 1 isoform X1

    2. XM_054329879.1 → XP_054185854.1  epithelial discoidin domain-containing receptor 1 isoform X5

    3. XM_054329875.1 → XP_054185850.1  epithelial discoidin domain-containing receptor 1 isoform X5

    4. XM_054329881.1 → XP_054185856.1  epithelial discoidin domain-containing receptor 1 isoform X5

    5. XM_054329870.1 → XP_054185845.1  epithelial discoidin domain-containing receptor 1 isoform X1

    6. XM_054329880.1 → XP_054185855.1  epithelial discoidin domain-containing receptor 1 isoform X5

    7. XM_054329872.1 → XP_054185847.1  epithelial discoidin domain-containing receptor 1 isoform X1

    8. XM_054329871.1 → XP_054185846.1  epithelial discoidin domain-containing receptor 1 isoform X1

    9. XM_054329876.1 → XP_054185851.1  epithelial discoidin domain-containing receptor 1 isoform X5

    10. XM_054329874.1 → XP_054185849.1  epithelial discoidin domain-containing receptor 1 isoform X2

    11. XM_054329877.1 → XP_054185852.1  epithelial discoidin domain-containing receptor 1 isoform X5

    12. XM_054329878.1 → XP_054185853.1  epithelial discoidin domain-containing receptor 1 isoform X5

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      2137265..2156466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330358.1 → XP_054186333.1  epithelial discoidin domain-containing receptor 1 isoform X6

    2. XM_054330363.1 → XP_054186338.1  epithelial discoidin domain-containing receptor 1 isoform X8

    3. XM_054330365.1 → XP_054186340.1  epithelial discoidin domain-containing receptor 1 isoform X8

    4. XM_054330356.1 → XP_054186331.1  epithelial discoidin domain-containing receptor 1 isoform X6

    5. XM_054330366.1 → XP_054186341.1  epithelial discoidin domain-containing receptor 1 isoform X8

    6. XM_054330357.1 → XP_054186332.1  epithelial discoidin domain-containing receptor 1 isoform X6

    7. XM_054330360.1 → XP_054186335.1  epithelial discoidin domain-containing receptor 1 isoform X8

    8. XM_054330369.1 → XP_054186344.1  epithelial discoidin domain-containing receptor 1 isoform X9

    9. XM_054330372.1 → XP_054186347.1  epithelial discoidin domain-containing receptor 1 isoform X12

    10. XM_054330367.1 → XP_054186342.1  epithelial discoidin domain-containing receptor 1 isoform X8

    11. XM_054330368.1 → XP_054186343.1  epithelial discoidin domain-containing receptor 1 isoform X8

    12. XM_054330364.1 → XP_054186339.1  epithelial discoidin domain-containing receptor 1 isoform X8

    13. XM_054330359.1 → XP_054186334.1  epithelial discoidin domain-containing receptor 1 isoform X7

    14. XM_054330370.1 → XP_054186345.1  epithelial discoidin domain-containing receptor 1 isoform X10

    15. XM_054330371.1 → XP_054186346.1  epithelial discoidin domain-containing receptor 1 isoform X11

    16. XM_054330361.1 → XP_054186336.1  epithelial discoidin domain-containing receptor 1 isoform X8

    17. XM_054330362.1 → XP_054186337.1  epithelial discoidin domain-containing receptor 1 isoform X8

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      2191212..2210394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330638.1 → XP_054186613.1  epithelial discoidin domain-containing receptor 1 isoform X1

    2. XM_054330645.1 → XP_054186620.1  epithelial discoidin domain-containing receptor 1 isoform X5

    3. XM_054330641.1 → XP_054186616.1  epithelial discoidin domain-containing receptor 1 isoform X5

    4. XM_054330648.1 → XP_054186623.1  epithelial discoidin domain-containing receptor 1 isoform X5

    5. XM_054330633.1 → XP_054186608.1  epithelial discoidin domain-containing receptor 1 isoform X1

    6. XM_054330647.1 → XP_054186622.1  epithelial discoidin domain-containing receptor 1 isoform X5

    7. XM_054330636.1 → XP_054186611.1  epithelial discoidin domain-containing receptor 1 isoform X1

    8. XM_054330637.1 → XP_054186612.1  epithelial discoidin domain-containing receptor 1 isoform X1

    9. XM_054330635.1 → XP_054186610.1  epithelial discoidin domain-containing receptor 1 isoform X1

    10. XM_054330634.1 → XP_054186609.1  epithelial discoidin domain-containing receptor 1 isoform X1

    11. XM_054330640.1 → XP_054186615.1  epithelial discoidin domain-containing receptor 1 isoform X2

    12. XM_054330651.1 → XP_054186626.1  epithelial discoidin domain-containing receptor 1 isoform X3

    13. XM_054330642.1 → XP_054186617.1  epithelial discoidin domain-containing receptor 1 isoform X5

    14. XM_054330646.1 → XP_054186621.1  epithelial discoidin domain-containing receptor 1 isoform X5

    15. XM_054330639.1 → XP_054186614.1  epithelial discoidin domain-containing receptor 1 isoform X2

    16. XM_054330649.1 → XP_054186624.1  epithelial discoidin domain-containing receptor 1 isoform X4

    17. XM_054330650.1 → XP_054186625.1  epithelial discoidin domain-containing receptor 1 isoform X3

    18. XM_054330643.1 → XP_054186618.1  epithelial discoidin domain-containing receptor 1 isoform X5

    19. XM_054330644.1 → XP_054186619.1  epithelial discoidin domain-containing receptor 1 isoform X5

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      2225119..2249066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      2136138..2155326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331135.1 → XP_054187110.1  epithelial discoidin domain-containing receptor 1 isoform X1

    2. XM_054331142.1 → XP_054187117.1  epithelial discoidin domain-containing receptor 1 isoform X5

    3. XM_054331138.1 → XP_054187113.1  epithelial discoidin domain-containing receptor 1 isoform X5

    4. XM_054331145.1 → XP_054187120.1  epithelial discoidin domain-containing receptor 1 isoform X5

    5. XM_054331130.1 → XP_054187105.1  epithelial discoidin domain-containing receptor 1 isoform X1

    6. XM_054331144.1 → XP_054187119.1  epithelial discoidin domain-containing receptor 1 isoform X5

    7. XM_054331133.1 → XP_054187108.1  epithelial discoidin domain-containing receptor 1 isoform X1

    8. XM_054331134.1 → XP_054187109.1  epithelial discoidin domain-containing receptor 1 isoform X1

    9. XM_054331132.1 → XP_054187107.1  epithelial discoidin domain-containing receptor 1 isoform X1

    10. XM_054331131.1 → XP_054187106.1  epithelial discoidin domain-containing receptor 1 isoform X1

    11. XM_054331137.1 → XP_054187112.1  epithelial discoidin domain-containing receptor 1 isoform X2

    12. XM_054331148.1 → XP_054187123.1  epithelial discoidin domain-containing receptor 1 isoform X3

    13. XM_054331139.1 → XP_054187114.1  epithelial discoidin domain-containing receptor 1 isoform X5

    14. XM_054331143.1 → XP_054187118.1  epithelial discoidin domain-containing receptor 1 isoform X5

    15. XM_054331136.1 → XP_054187111.1  epithelial discoidin domain-containing receptor 1 isoform X2

    16. XM_054331146.1 → XP_054187121.1  epithelial discoidin domain-containing receptor 1 isoform X4

    17. XM_054331147.1 → XP_054187122.1  epithelial discoidin domain-containing receptor 1 isoform X3

    18. XM_054331140.1 → XP_054187115.1  epithelial discoidin domain-containing receptor 1 isoform X5

    19. XM_054331141.1 → XP_054187116.1  epithelial discoidin domain-containing receptor 1 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      30745627..30764828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356365.1 → XP_054212340.1  epithelial discoidin domain-containing receptor 1 isoform X1

    2. XM_054356371.1 → XP_054212346.1  epithelial discoidin domain-containing receptor 1 isoform X5

    3. XM_054356375.1 → XP_054212350.1  epithelial discoidin domain-containing receptor 1 isoform X5

    4. XM_054356374.1 → XP_054212349.1  epithelial discoidin domain-containing receptor 1 isoform X5

    5. XM_054356366.1 → XP_054212341.1  epithelial discoidin domain-containing receptor 1 isoform X2

    6. XM_054356369.1 → XP_054212344.1  epithelial discoidin domain-containing receptor 1 isoform X5

    7. XM_054356370.1 → XP_054212345.1  epithelial discoidin domain-containing receptor 1 isoform X5

    8. XM_054356358.1 → XP_054212333.1  epithelial discoidin domain-containing receptor 1 isoform X1

    9. XM_054356373.1 → XP_054212348.1  epithelial discoidin domain-containing receptor 1 isoform X5

    10. XM_054356359.1 → XP_054212334.1  epithelial discoidin domain-containing receptor 1 isoform X1

    11. XM_054356362.1 → XP_054212337.1  epithelial discoidin domain-containing receptor 1 isoform X1

    12. XM_054356364.1 → XP_054212339.1  epithelial discoidin domain-containing receptor 1 isoform X1

    13. XM_054356363.1 → XP_054212338.1  epithelial discoidin domain-containing receptor 1 isoform X1

    14. XM_054356361.1 → XP_054212336.1  epithelial discoidin domain-containing receptor 1 isoform X1

    15. XM_054356367.1 → XP_054212342.1  epithelial discoidin domain-containing receptor 1 isoform X2

    16. XM_054356376.1 → XP_054212351.1  epithelial discoidin domain-containing receptor 1 isoform X3

    17. XM_054356372.1 → XP_054212347.1  epithelial discoidin domain-containing receptor 1 isoform X5

    18. XM_054356368.1 → XP_054212343.1  epithelial discoidin domain-containing receptor 1 isoform X5

    19. XM_054356360.1 → XP_054212335.1  epithelial discoidin domain-containing receptor 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08345.1 GenPept UniProtKB/Swiss-Prot:Q08345

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