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    TRIM17 tripartite motif containing 17 [ Homo sapiens (human) ]

    Gene ID: 51127, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TRIM17provided by HGNC
    Official Full Name
    tripartite motif containing 17provided by HGNC
    Primary source
    HGNC:HGNC:13430
    See related
    Ensembl:ENSG00000162931 MIM:606123; AllianceGenome:HGNC:13430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RBCC; terf; RNF16
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 5.7), spleen (RPKM 1.3) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIM17 in Genome Data Viewer
    Location:
    1q42.13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (228407935..228416861, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227596448..227605374, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228595636..228604562, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene uncharacterized LOC101927401 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228555546-228556114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228556115-228556682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228557329-228557895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228557896-228558461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228578692-228579248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228579249-228579804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228587477-228588152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228589505-228590179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228595439-228596098 Neighboring gene uncharacterized LOC124904537 Neighboring gene microRNA 6742 Neighboring gene tripartite motif containing 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1920 Neighboring gene uncharacterized LOC124904538 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:228628090-228628374 Neighboring gene H3.4 histone, cluster member

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation. Mandell MA, et al. J Cell Sci, 2016 Oct 1. PMID 27562068, Free PMC Article
    2. MiR-1246 is responsible for lung cancer cells-derived exosomes-mediated promoting effects on lung cancer stemness via targeting TRIM17. Liu Z, et al. Environ Toxicol, 2022 Nov. PMID 35894553
    3. TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer. Zhong T, et al. Cell Oncol (Dordr), 2023 Oct. PMID 37219768
    4. Chromosome mapping of RNF16 and rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family. Ogawa S, et al. Cytogenet Cell Genet, 2000. PMID 10894938
    5. Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation. Endo H, et al. J Biochem, 2012 Feb. PMID 22023800

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer.
      Title: TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer.
    2. MiR-1246 is responsible for lung cancer cells-derived exosomes-mediated promoting effects on lung cancer stemness via targeting TRIM17.
      Title: MiR-1246 is responsible for lung cancer cells-derived exosomes-mediated promoting effects on lung cancer stemness via targeting TRIM17.
    3. overexpression of TRIM28 or knock-out of TRIM17 reduced BCLA1 protein levels and restored sensitivity of melanoma cells to BRAF-targeted therapy. Therefore, our data describe a molecular rheostat in which two proteins of the TRIM family antagonistically regulate BCL2A1 stability and modulate cell death.
      Title: TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1.
    4. data suggest LSD1 largely plays a tumor suppressor role in luminal breast cancer and the oncogenic program associated with LSD1-inhibition may be suppressed via TRIM37-inhibition
      Title: LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression.
    5. deregulation of the TRIM17/TRIM41/ZSCAN21 pathway may be involved in the pathogenesis of Parkinson's disease.
      Title: The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate α-Synuclein Expression by Regulating ZSCAN21.
    6. TRIM17 promoted the removal of midbodies, remnants of the cell division machinery that are known autophagy targets.
      Title: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation.
    7. NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis
      Title: Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17.
    8. the E3 ubiquitin ligase terf causes protein degradation of ZWINT and negatively regulates cell proliferation
      Title: Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Candidate-gene testing for orphan limb-girdle muscular dystrophies.
    10. terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein.
      Title: TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM17
    Names
    RING finger protein terf
    RING-type E3 ubiquitin transferase TRIM17
    ring finger protein 16
    testis RING finger protein
    tripartite motif-containing protein 17
    NP_001020111.1
    NP_001128327.1
    NP_057186.1
    XP_006711842.1
    XP_011542511.1
    XP_011542512.1
    XP_011542513.1
    XP_016856908.1
    XP_047278034.1
    XP_047278044.1
    XP_047278047.1
    XP_047278054.1
    XP_047278059.1
    XP_054192869.1
    XP_054192870.1
    XP_054192871.1
    XP_054192872.1
    XP_054192873.1
    XP_054192874.1
    XP_054192875.1
    XP_054192876.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024940.3 → NP_001020111.1  E3 ubiquitin-protein ligase TRIM17 isoform 1

      See identical proteins and their annotated locations for NP_001020111.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AW770403, BC033788, DA270450
      Consensus CDS
      CCDS1571.1
      UniProtKB/Swiss-Prot
      B4DVJ2, Q5VST8, Q9Y577
      Related
      ENSP00000295033.3, ENST00000295033.7
      Conserved Domains (3) summary
      cd00021
      Location:97 → 134
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15812
      Location:296 → 472
      SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
      cd16595
      Location:13 → 66
      RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins

    2. NM_001134855.2 → NP_001128327.1  E3 ubiquitin-protein ligase TRIM17 isoform 3

      See identical proteins and their annotated locations for NP_001128327.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 3' coding region and UTR, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct C-terminus that lacks a SPRY domain, compared to isoform 1.
      Source sequence(s)
      AK308774, DC309740
      Consensus CDS
      CCDS44327.1
      UniProtKB/TrEMBL
      B7ZAR4
      Related
      ENSP00000403312.2, ENST00000456946.6
      Conserved Domains (2) summary
      cd00021
      Location:97 → 134
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl17238
      Location:16 → 65
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    3. NM_016102.4 → NP_057186.1  E3 ubiquitin-protein ligase TRIM17 isoform 1

      See identical proteins and their annotated locations for NP_057186.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AW770403, BC033788, DA270450, DB031719
      Consensus CDS
      CCDS1571.1
      UniProtKB/Swiss-Prot
      B4DVJ2, Q5VST8, Q9Y577
      Related
      ENSP00000355659.2, ENST00000366698.7
      Conserved Domains (3) summary
      cd00021
      Location:97 → 134
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15812
      Location:296 → 472
      SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
      cd16595
      Location:13 → 66
      RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      228407935..228416861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422088.1 → XP_047278044.1  E3 ubiquitin-protein ligase TRIM17 isoform X2

    2. XM_011544211.4 → XP_011542513.1  E3 ubiquitin-protein ligase TRIM17 isoform X2

      See identical proteins and their annotated locations for XP_011542513.1

      Conserved Domains (3) summary
      cd00021
      Location:70 → 107
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15812
      Location:269 → 445
      SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
      cl17238
      Location:4 → 38
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    3. XM_017001419.2 → XP_016856908.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

      UniProtKB/TrEMBL
      B3KP04, E5RJW6
      Related
      ENSP00000430468.1, ENST00000479800.1
      Conserved Domains (2) summary
      cd00021
      Location:97 → 134
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl17238
      Location:16 → 65
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    4. XM_011544210.4 → XP_011542512.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

      See identical proteins and their annotated locations for XP_011542512.1

      UniProtKB/Swiss-Prot
      B4DVJ2, Q5VST8, Q9Y577
      Conserved Domains (3) summary
      cd00021
      Location:97 → 134
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15812
      Location:296 → 472
      SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
      cd16595
      Location:13 → 66
      RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins

    5. XM_047422103.1 → XP_047278059.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

      UniProtKB/TrEMBL
      B3KP04

    6. XM_006711779.4 → XP_006711842.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

      See identical proteins and their annotated locations for XP_006711842.1

      UniProtKB/Swiss-Prot
      B4DVJ2, Q5VST8, Q9Y577
      Conserved Domains (3) summary
      cd00021
      Location:97 → 134
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15812
      Location:296 → 472
      SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
      cd16595
      Location:13 → 66
      RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins

    7. XM_047422098.1 → XP_047278054.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

      UniProtKB/TrEMBL
      B3KP04

    8. XM_011544209.4 → XP_011542511.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

      See identical proteins and their annotated locations for XP_011542511.1

      UniProtKB/Swiss-Prot
      B4DVJ2, Q5VST8, Q9Y577
      Conserved Domains (3) summary
      cd00021
      Location:97 → 134
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15812
      Location:296 → 472
      SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
      cd16595
      Location:13 → 66
      RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins

    9. XM_047422091.1 → XP_047278047.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

      UniProtKB/TrEMBL
      B3KP04

    10. XM_047422078.1 → XP_047278034.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

      UniProtKB/Swiss-Prot
      B4DVJ2, Q5VST8, Q9Y577
      Related
      ENSP00000355658.2, ENST00000366697.6

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654708.1 Reference GRCh38.p14 PATCHES

      Range
      1..8060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      227596448..227605374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336897.1 → XP_054192872.1  E3 ubiquitin-protein ligase TRIM17 isoform X2

    2. XM_054336898.1 → XP_054192873.1  E3 ubiquitin-protein ligase TRIM17 isoform X2

    3. XM_054336895.1 → XP_054192870.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

      UniProtKB/Swiss-Prot
      B4DVJ2, Q5VST8, Q9Y577

    4. XM_054336894.1 → XP_054192869.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

      UniProtKB/Swiss-Prot
      B4DVJ2, Q5VST8, Q9Y577

    5. XM_054336896.1 → XP_054192871.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

      UniProtKB/Swiss-Prot
      B4DVJ2, Q5VST8, Q9Y577

    6. XM_054336901.1 → XP_054192876.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

      UniProtKB/TrEMBL
      B3KP04

    7. XM_054336900.1 → XP_054192875.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

      UniProtKB/TrEMBL
      B3KP04

    8. XM_054336899.1 → XP_054192874.1  E3 ubiquitin-protein ligase TRIM17 isoform X3

      UniProtKB/TrEMBL
      B3KP04

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024941.2: Suppressed sequence

      Description
      NM_001024941.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y577.1 GenPept UniProtKB/Swiss-Prot:Q9Y577

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