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    PPFIA1 PTPRF interacting protein alpha 1 [ Homo sapiens (human) ]

    Gene ID: 8500, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PPFIA1provided by HGNC
    Official Full Name
    PTPRF interacting protein alpha 1provided by HGNC
    Primary source
    HGNC:HGNC:9245
    See related
    Ensembl:ENSG00000131626 MIM:611054; AllianceGenome:HGNC:9245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LIP1; LIP.1; LIPRIN
    Summary
    The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 18.0), thyroid (RPKM 12.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PPFIA1 in Genome Data Viewer
    Location:
    11q13.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (70270690..70384396)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (70285642..70404818)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (70116796..70230502)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3699 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70049941-70050132 Neighboring gene uncharacterized LOC124902705 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70058905-70059714 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70059715-70060524 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70060525-70061332 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:70065875-70066575 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:70075454-70075954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3701 Neighboring gene uncharacterized LOC107984346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70148375-70148874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70157785-70158680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70158681-70159574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:70156675-70157176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70159641-70160157 Neighboring gene Fas associated via death domain Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70166538-70166719 Neighboring gene uncharacterized LOC105369373 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70175478-70175614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70187532-70188110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70188111-70188688 Neighboring gene microRNA 548k Neighboring gene H2A.Z histone pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70230466-70230972 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:70235067-70235838 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70235839-70236608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70237380-70238149 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70242965-70243153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3702 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3703 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3704 Neighboring gene Sharpr-MPRA regulatory region 1776 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70250285-70250464 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70261331-70261532 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:70265651-70266850 Neighboring gene CTTN divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70289993-70290826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70343973-70344473 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70346781-70346940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70351607-70352106 Neighboring gene cortactin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70364325-70364826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70369495-70370452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70370453-70371408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70371409-70372366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70373323-70374279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70385241-70385858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70384621-70385240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70390839-70391673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70392509-70393343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70393780-70394730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70397475-70397990 Neighboring gene SH3 and multiple ankyrin repeat domains 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:70399135-70400334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70403420-70404150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70404151-70404881 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70423187-70423687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70422686-70423186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70425215-70425716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70428716-70429218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70429219-70429720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70429721-70430223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70430775-70431315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70457727-70458490 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70464553-70465368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70465369-70466183 Neighboring gene SHANK2 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Liprin-α1 contributes to oncogenic MAPK signaling by counteracting ERK activity. Pehkonen H, et al. Mol Oncol, 2024 Mar. PMID 38264964, Free PMC Article
    2. Liprin phosphorylation regulates binding to LAR: evidence for liprin autophosphorylation. Serra-Pagès C, et al. Biochemistry, 2005 Dec 6. PMID 16313174, Free PMC Article
    3. Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, in head and neck squamous cell carcinoma. Tan KD, et al. Genes Chromosomes Cancer, 2008 Apr. PMID 18196592
    4. Liprin-alpha1 promotes cell spreading on the extracellular matrix by affecting the distribution of activated integrins. Asperti C, et al. J Cell Sci, 2009 Sep 15. PMID 19690048
    5. High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis. Gao Y, et al. BMC Cancer, 2023 May 9. PMID 37158817, Free PMC Article

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Liprin-alpha1 contributes to oncogenic MAPK signaling by counteracting ERK activity.
      Title: Liprin-α1 contributes to oncogenic MAPK signaling by counteracting ERK activity.
    2. High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis.
      Title: High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis.
    3. Oligomerized liprin-alpha promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.
      Title: Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.
    4. Quantifying Polarized Extracellular Matrix Secretion in Cultured Endothelial Cells.
      Title: Quantifying Polarized Extracellular Matrix Secretion in Cultured Endothelial Cells.
    5. We found that PPFIA1 and ALG3 were distinctively overexpressed at the mRNA level in HNSCC tissues compared with normal tissues, they had a significant co-occurrence relationship. Patients without both PPFIA1 and ALG3 mRNA expression alterations had better overall survival and disease/progression-free survival compared with patients with both PPFIA1 and ALG3 alterations.
      Title: Combined expression and prognostic significance of PPFIA1 and ALG3 in head and neck squamous cell carcinoma.
    6. liprin-alpha1 as a novel regulator of CD82
      Title: Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton.
    7. The results indicate that liprin-alpha1, LL5 and ERC1 define a novel dynamic membrane-less compartment that regulates matrix degradation by affecting invadosome motility.
      Title: Identification of a membrane-less compartment regulating invadosome function and motility.
    8. This study shows that PPFIA1 is required for FN polymerization-dependent vascular morphogenesis, both in vitro and in the developing zebrafish embryo.
      Title: PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis.
    9. Based on these findings, we infer that high PPFIA1 expression might be an independent prognostic indicator of increased metastatic relapse risk in patients with estrogen receptor+/N- breast cancer, but not in estrogen receptor+/N+ or estrogen receptor- patients.
      Title: PPFIA1 is upregulated in liver metastasis of breast cancer and is a potential poor prognostic indicator of metastatic relapse.
    10. These results indicate that liprin-alpha1 localizes to different adhesion and cytoskeletal structures to regulate vimentin intermediate filament network, thereby altering the invasion and growth properties of the cancer cells.
      Title: Liprin-α1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag interacts with PFFIA1 as demonstrated by proximity dependent biotinylation proteomics PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41337, FLJ42630, FLJ43474, MGC26800

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic active zone TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spine apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    liprin-alpha-1
    Names
    LAR-interacting protein 1
    LIP-1
    Liprin-alpha1
    protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1
    protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378006.1 → NP_001364935.1  liprin-alpha-1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AP000487, AP002336, KC877433
      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Conserved Domains (5) summary
      cd09562
      Location:910 → 980
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1027 → 1092
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1112 → 1183
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:246 → 546
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:45 → 687
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_003626.5 → NP_003617.1  liprin-alpha-1 isoform b

      See identical proteins and their annotated locations for NP_003617.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and it encodes the longer protein (isoform b).
      Source sequence(s)
      AP000487, AP002336, KC877433
      Consensus CDS
      CCDS31627.1
      UniProtKB/Swiss-Prot
      A6NLE3, Q13135, Q13136, Q14567, Q8N4I2
      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Related
      ENSP00000253925.7, ENST00000253925.12
      Conserved Domains (6) summary
      cd09562
      Location:875 → 945
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:962 → 1027
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1047 → 1118
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1048 → 1118
      SAM; Sterile alpha motif
      pfam12795
      Location:321 → 517
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324 → 445
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. NM_177423.3 → NP_803172.1  liprin-alpha-1 isoform a

      See identical proteins and their annotated locations for NP_803172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 3' end, which includes a part of the coding region and 3' UTR, as compared to variant 2. The resulting protein (isoform a) has a distinct and shorter C-terminus, as compared to isoform b.
      Source sequence(s)
      AP000487, AP002336, KC877433
      Consensus CDS
      CCDS31628.1
      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Related
      ENSP00000374198.3, ENST00000389547.7
      Conserved Domains (6) summary
      cd09562
      Location:875 → 945
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:962 → 1027
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1047 → 1118
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1048 → 1118
      SAM; Sterile alpha motif
      pfam12795
      Location:321 → 517
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324 → 445
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. NR_045286.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in an internal exon and contains an alternate exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP000487, AP002336, KC877433
      Related
      ENST00000532504.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      70270690..70384396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006718716.4 → XP_006718779.1  liprin-alpha-1 isoform X1

      See identical proteins and their annotated locations for XP_006718779.1

      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Conserved Domains (7) summary
      cd09562
      Location:949 → 1019
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1066 → 1131
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1151 → 1222
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1152 → 1222
      SAM; Sterile alpha motif
      pfam00836
      Location:416 → 524
      Stathmin; Stathmin family
      pfam12795
      Location:321 → 542
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324 → 470
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_011545309.3 → XP_011543611.1  liprin-alpha-1 isoform X4

      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Conserved Domains (6) summary
      cd09562
      Location:949 → 1019
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1066 → 1131
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1151 → 1222
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1152 → 1222
      SAM; Sterile alpha motif
      pfam00836
      Location:416 → 524
      Stathmin; Stathmin family
      pfam12795
      Location:321 → 542
      MscS_porin; Mechanosensitive ion channel porin domain

    3. XM_011545307.4 → XP_011543609.1  liprin-alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Conserved Domains (7) summary
      cd09562
      Location:949 → 1019
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1057 → 1122
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1142 → 1213
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1143 → 1213
      SAM; Sterile alpha motif
      pfam00836
      Location:416 → 524
      Stathmin; Stathmin family
      pfam12795
      Location:321 → 542
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324 → 470
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_011545311.4 → XP_011543613.1  liprin-alpha-1 isoform X7

      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Conserved Domains (7) summary
      cd09562
      Location:949 → 1019
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1037 → 1102
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1122 → 1193
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1123 → 1193
      SAM; Sterile alpha motif
      pfam00836
      Location:416 → 524
      Stathmin; Stathmin family
      pfam12795
      Location:321 → 542
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324 → 470
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. XM_011545312.3 → XP_011543614.1  liprin-alpha-1 isoform X8

      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Conserved Domains (7) summary
      cd09562
      Location:949 → 1019
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1036 → 1101
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1121 → 1192
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1122 → 1192
      SAM; Sterile alpha motif
      pfam00836
      Location:416 → 524
      Stathmin; Stathmin family
      pfam12795
      Location:321 → 542
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324 → 470
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_011545308.4 → XP_011543610.1  liprin-alpha-1 isoform X3

      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Conserved Domains (7) summary
      cd09562
      Location:939 → 1009
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1056 → 1121
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1141 → 1212
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1142 → 1212
      SAM; Sterile alpha motif
      pfam00836
      Location:416 → 524
      Stathmin; Stathmin family
      pfam12795
      Location:321 → 542
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324 → 470
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. XM_017018448.2 → XP_016873937.1  liprin-alpha-1 isoform X10

      UniProtKB/TrEMBL
      A0A2R8Y7R9

    8. XM_011545316.3 → XP_011543618.1  liprin-alpha-1 isoform X16

      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Conserved Domains (5) summary
      cd09562
      Location:910 → 980
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:997 → 1062
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1082 → 1153
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1083 → 1153
      SAM; Sterile alpha motif
      pfam12795
      Location:321 → 542
      MscS_porin; Mechanosensitive ion channel porin domain

    9. XM_011545314.4 → XP_011543616.1  liprin-alpha-1 isoform X11

      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Conserved Domains (6) summary
      cd09562
      Location:900 → 970
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1017 → 1082
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1102 → 1173
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1103 → 1173
      SAM; Sterile alpha motif
      pfam00836
      Location:416 → 524
      Stathmin; Stathmin family
      pfam12795
      Location:321 → 542
      MscS_porin; Mechanosensitive ion channel porin domain

    10. XM_047427770.1 → XP_047283726.1  liprin-alpha-1 isoform X18

    11. XM_047427772.1 → XP_047283728.1  liprin-alpha-1 isoform X21

    12. XM_011545317.3 → XP_011543619.1  liprin-alpha-1 isoform X19

      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Conserved Domains (5) summary
      cd09562
      Location:900 → 970
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:987 → 1052
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1072 → 1143
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1073 → 1143
      SAM; Sterile alpha motif
      pfam12795
      Location:321 → 542
      MscS_porin; Mechanosensitive ion channel porin domain

    13. XM_047427773.1 → XP_047283729.1  liprin-alpha-1 isoform X22

    14. XM_011545310.4 → XP_011543612.1  liprin-alpha-1 isoform X6

      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Conserved Domains (6) summary
      cd09562
      Location:924 → 994
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1041 → 1106
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1126 → 1197
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1127 → 1197
      SAM; Sterile alpha motif
      pfam12795
      Location:321 → 517
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324 → 445
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    15. XM_047427766.1 → XP_047283722.1  liprin-alpha-1 isoform X12

    16. XM_047427765.1 → XP_047283721.1  liprin-alpha-1 isoform X9

    17. XM_047427767.1 → XP_047283723.1  liprin-alpha-1 isoform X14

    18. XM_047427768.1 → XP_047283724.1  liprin-alpha-1 isoform X15

    19. XM_011545315.3 → XP_011543617.1  liprin-alpha-1 isoform X13

      UniProtKB/TrEMBL
      A0A2R8Y7R9, A0AAG2UWZ2
      Related
      ENSP00000496327.1, ENST00000644155.1
      Conserved Domains (6) summary
      cd09562
      Location:885 → 955
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1002 → 1067
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1087 → 1158
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1088 → 1158
      SAM; Sterile alpha motif
      pfam12795
      Location:321 → 517
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324 → 445
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    20. XM_011545319.2 → XP_011543621.1  liprin-alpha-1 isoform X27

      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Conserved Domains (6) summary
      cd09562
      Location:885 → 955
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:993 → 1058
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1078 → 1149
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1079 → 1149
      SAM; Sterile alpha motif
      pfam12795
      Location:321 → 517
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324 → 445
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    21. XM_017018449.2 → XP_016873938.1  liprin-alpha-1 isoform X23

      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Conserved Domains (5) summary
      cd09562
      Location:885 → 955
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:972 → 1037
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1057 → 1128
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 441
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:270 → 517
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    22. XM_047427769.1 → XP_047283725.1  liprin-alpha-1 isoform X17

    23. XM_047427771.1 → XP_047283727.1  liprin-alpha-1 isoform X20

    24. XM_047427774.1 → XP_047283730.1  liprin-alpha-1 isoform X24

    25. XM_047427775.1 → XP_047283731.1  liprin-alpha-1 isoform X25

    26. XM_047427763.1 → XP_047283719.1  liprin-alpha-1 isoform X5

    27. XM_047427764.1 → XP_047283720.1  liprin-alpha-1 isoform X6

    28. XM_011545306.4 → XP_011543608.1  liprin-alpha-1 isoform X1

      See identical proteins and their annotated locations for XP_011543608.1

      UniProtKB/TrEMBL
      A0A2R8Y7R9
      Conserved Domains (7) summary
      cd09562
      Location:949 → 1019
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1066 → 1131
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1151 → 1222
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1152 → 1222
      SAM; Sterile alpha motif
      pfam00836
      Location:416 → 524
      Stathmin; Stathmin family
      pfam12795
      Location:321 → 542
      MscS_porin; Mechanosensitive ion channel porin domain
      cl12013
      Location:324 → 470
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    29. XM_047427776.1 → XP_047283732.1  liprin-alpha-1 isoform X26

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160005.1 Reference GRCh38.p14 PATCHES

      Range
      26511..145684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332477.1 → XP_054188452.1  liprin-alpha-1 isoform X1

    2. XM_054332481.1 → XP_054188456.1  liprin-alpha-1 isoform X4

    3. XM_054332479.1 → XP_054188454.1  liprin-alpha-1 isoform X2

    4. XM_054332485.1 → XP_054188460.1  liprin-alpha-1 isoform X7

    5. XM_054332486.1 → XP_054188461.1  liprin-alpha-1 isoform X8

    6. XM_054332480.1 → XP_054188455.1  liprin-alpha-1 isoform X3

    7. XM_054332488.1 → XP_054188463.1  liprin-alpha-1 isoform X10

    8. XM_054332494.1 → XP_054188469.1  liprin-alpha-1 isoform X16

    9. XM_054332489.1 → XP_054188464.1  liprin-alpha-1 isoform X11

    10. XM_054332496.1 → XP_054188471.1  liprin-alpha-1 isoform X18

    11. XM_054332499.1 → XP_054188474.1  liprin-alpha-1 isoform X21

    12. XM_054332497.1 → XP_054188472.1  liprin-alpha-1 isoform X19

    13. XM_054332500.1 → XP_054188475.1  liprin-alpha-1 isoform X22

    14. XM_054332483.1 → XP_054188458.1  liprin-alpha-1 isoform X6

    15. XM_054332490.1 → XP_054188465.1  liprin-alpha-1 isoform X12

    16. XM_054332487.1 → XP_054188462.1  liprin-alpha-1 isoform X9

    17. XM_054332492.1 → XP_054188467.1  liprin-alpha-1 isoform X14

    18. XM_054332493.1 → XP_054188468.1  liprin-alpha-1 isoform X15

    19. XM_054332491.1 → XP_054188466.1  liprin-alpha-1 isoform X13

      UniProtKB/TrEMBL
      A0AAG2UWZ2

    20. XM_054332505.1 → XP_054188480.1  liprin-alpha-1 isoform X27

    21. XM_054332501.1 → XP_054188476.1  liprin-alpha-1 isoform X23

    22. XM_054332495.1 → XP_054188470.1  liprin-alpha-1 isoform X17

    23. XM_054332498.1 → XP_054188473.1  liprin-alpha-1 isoform X20

    24. XM_054332502.1 → XP_054188477.1  liprin-alpha-1 isoform X24

    25. XM_054332503.1 → XP_054188478.1  liprin-alpha-1 isoform X25

    26. XM_054332482.1 → XP_054188457.1  liprin-alpha-1 isoform X5

    27. XM_054332484.1 → XP_054188459.1  liprin-alpha-1 isoform X6

    28. XM_054332478.1 → XP_054188453.1  liprin-alpha-1 isoform X1

    29. XM_054332504.1 → XP_054188479.1  liprin-alpha-1 isoform X26

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      70285642..70404818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370272.1 → XP_054226247.1  liprin-alpha-1 isoform X1

    2. XM_054370276.1 → XP_054226251.1  liprin-alpha-1 isoform X4

    3. XM_054370274.1 → XP_054226249.1  liprin-alpha-1 isoform X2

    4. XM_054370280.1 → XP_054226255.1  liprin-alpha-1 isoform X7

    5. XM_054370281.1 → XP_054226256.1  liprin-alpha-1 isoform X8

    6. XM_054370275.1 → XP_054226250.1  liprin-alpha-1 isoform X3

    7. XM_054370283.1 → XP_054226258.1  liprin-alpha-1 isoform X10

    8. XM_054370289.1 → XP_054226264.1  liprin-alpha-1 isoform X16

    9. XM_054370284.1 → XP_054226259.1  liprin-alpha-1 isoform X11

    10. XM_054370291.1 → XP_054226266.1  liprin-alpha-1 isoform X18

    11. XM_054370294.1 → XP_054226269.1  liprin-alpha-1 isoform X21

    12. XM_054370292.1 → XP_054226267.1  liprin-alpha-1 isoform X19

    13. XM_054370295.1 → XP_054226270.1  liprin-alpha-1 isoform X22

    14. XM_054370278.1 → XP_054226253.1  liprin-alpha-1 isoform X6

    15. XM_054370285.1 → XP_054226260.1  liprin-alpha-1 isoform X12

    16. XM_054370282.1 → XP_054226257.1  liprin-alpha-1 isoform X9

    17. XM_054370287.1 → XP_054226262.1  liprin-alpha-1 isoform X14

    18. XM_054370288.1 → XP_054226263.1  liprin-alpha-1 isoform X15

    19. XM_054370286.1 → XP_054226261.1  liprin-alpha-1 isoform X13

      UniProtKB/TrEMBL
      A0AAG2UWZ2

    20. XM_054370300.1 → XP_054226275.1  liprin-alpha-1 isoform X27

    21. XM_054370296.1 → XP_054226271.1  liprin-alpha-1 isoform X23

    22. XM_054370290.1 → XP_054226265.1  liprin-alpha-1 isoform X17

    23. XM_054370293.1 → XP_054226268.1  liprin-alpha-1 isoform X20

    24. XM_054370297.1 → XP_054226272.1  liprin-alpha-1 isoform X24

    25. XM_054370298.1 → XP_054226273.1  liprin-alpha-1 isoform X25

    26. XM_054370277.1 → XP_054226252.1  liprin-alpha-1 isoform X5

    27. XM_054370279.1 → XP_054226254.1  liprin-alpha-1 isoform X6

    28. XM_054370273.1 → XP_054226248.1  liprin-alpha-1 isoform X1

    29. XM_054370299.1 → XP_054226274.1  liprin-alpha-1 isoform X26

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13136.1 GenPept UniProtKB/Swiss-Prot:Q13136

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