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    DNAJC4 DnaJ heat shock protein family (Hsp40) member C4 [ Homo sapiens (human) ]

    Gene ID: 3338, updated on 28-Oct-2024

    Summary

    Official Symbol
    DNAJC4provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C4provided by HGNC
    Primary source
    HGNC:HGNC:5271
    See related
    Ensembl:ENSG00000110011 MIM:604189; AllianceGenome:HGNC:5271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSPF2; MCG18; DANJC4
    Summary
    Predicted to be involved in response to unfolded protein. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in testis (RPKM 43.6), spleen (RPKM 17.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DNAJC4 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64230432..64234281)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64220128..64224226)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63997904..64001753)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FERM domain containing kindlin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63992564-63993286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63993887-63994406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63994407-63994924 Neighboring gene tRNA phosphotransferase 1 Neighboring gene uncharacterized LOC124902687 Neighboring gene nudix hydrolase 22 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3467 Neighboring gene vascular endothelial growth factor B Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:64007574-64008476 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:64008477-64009377 Neighboring gene uncharacterized LOC114841035 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3469 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64010280-64011180 Neighboring gene FKBP prolyl isomerase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC19482, MGC57189, MGC71863

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein folding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to unfolded protein TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 4
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 4
    dnaJ-like protein HSPF2
    heat shock 40kD protein 2
    multiple endocrine neoplasia type 1 candidate protein number 18

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001307980.1NP_001294909.1  dnaJ homolog subfamily C member 4 isoform 1

      See identical proteins and their annotated locations for NP_001294909.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF036874, AP001453, BC032137, BC044584
      Consensus CDS
      CCDS76424.1
      UniProtKB/TrEMBL
      J3KNJ8, Q86VG4
      Related
      ENSP00000320548.5, ENST00000321460.5
      Conserved Domains (1) summary
      pfam00226
      Location:3496
      DnaJ; DnaJ domain
    2. NM_001307981.1NP_001294910.1  dnaJ homolog subfamily C member 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site at an internal exon. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AP001453, BC044584, BC051008
      UniProtKB/TrEMBL
      Q86VG4
      Conserved Domains (1) summary
      pfam00226
      Location:3496
      DnaJ; DnaJ domain
    3. NM_005528.4NP_005519.2  dnaJ homolog subfamily C member 4 isoform 3

      See identical proteins and their annotated locations for NP_005519.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and uses alternate splice sites in the 3' coding region, resulting in a frameshift and novel 3' coding region compared to variant 1. It encodes isoform 3, which is shorter than and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC053947
      Consensus CDS
      CCDS41666.1
      UniProtKB/Swiss-Prot
      O14716, Q9NNZ3
      Related
      ENSP00000486499.2, ENST00000628077.3
      Conserved Domains (1) summary
      pfam00226
      Location:3496
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      64230432..64234281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426865.1XP_047282821.1  dnaJ homolog subfamily C member 4 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      64220128..64224226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368615.1XP_054224590.1  dnaJ homolog subfamily C member 4 isoform X2

    2. XM_054368617.1XP_054224592.1  dnaJ homolog subfamily C member 4 isoform X3

      UniProtKB/Swiss-Prot
      O14716, Q9NNZ3
    3. XM_054368616.1XP_054224591.1  dnaJ homolog subfamily C member 4 isoform X1