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    GLO2 hydroxyacylglutathione hydrolase GLO2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851865, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GLO2
    Official Full Name
    hydroxyacylglutathione hydrolase GLO2
    Primary source
    SGD:S000002680
    Locus tag
    YDR272W
    See related
    AllianceGenome:SGD:S000002680; FungiDB:YDR272W; VEuPathDB:YDR272W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables hydroxyacylglutathione hydrolase activity. Involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Located in cytoplasm. Human ortholog(s) of this gene implicated in paroxysmal nonkinesigenic dyskinesia 1. Orthologous to several human genes including HAGH (hydroxyacylglutathione hydrolase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See GLO2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1009010..1009834)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tryptophan--tRNA ligase MSW1 Neighboring gene Cu(2+)-transporting P-type ATPase CCC2 Neighboring gene Don1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glyoxalase II in Saccharomyces cerevisiae: in situ kinetics using the 5,5'-dithiobis(2-nitrobenzoic acid) assay. Martins AM, et al. Arch Biochem Biophys, 1999 Jun 1. PMID 10334858
    2. In situ kinetic analysis of glyoxalase I and glyoxalase II in Saccharomyces cerevisiae. Martins AM, et al. Eur J Biochem, 2001 Jul. PMID 11453985
    3. Heterologous expression, purification, and kinetic comparison of the cytoplasmic and mitochondrial glyoxalase II enzymes, Glo2p and Glo4p, from Saccharomyces cerevisiae. Bito A, et al. Protein Expr Purif, 1999 Dec. PMID 10600466
    4. Identification and phenotypic analysis of two glyoxalase II encoding genes from Saccharomyces cerevisiae, GLO2 and GLO4, and intracellular localization of the corresponding proteins. Bito A, et al. J Biol Chem, 1997 Aug 22. PMID 9261170
    5. Yeasts as Complementary Model Systems for the Study of the Pathological Repercussions of Enhanced Synphilin-1 Glycation and Oxidation. Seynnaeve D, et al. Int J Mol Sci, 2021 Feb 7. PMID 33562355, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxyacylglutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables hydroxyacylglutathione hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hydroxyacylglutathione hydrolase GLO2
    NP_010558.3
    • Cytoplasmic glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO2 has a paralog, GLO4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1009010..1009834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180580.3 → NP_010558.3  TPA: hydroxyacylglutathione hydrolase GLO2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010558.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSQ4, E9P8T0, Q05584
      UniProtKB/TrEMBL
      A6ZYM3, B3LG20, B5VGF4, C7GS91, C8Z5I5, G2WB13, N1P8I8
      Conserved Domains (2) summary
      cd07723
      Location:16 → 188
      hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
      pfam16123
      Location:189 → 273
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05584.1

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