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    RDR1 Rdr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854562, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RDR1
    Official Full Name
    Rdr1p
    Primary source
    SGD:S000005907
    Locus tag
    YOR380W
    See related
    AllianceGenome:SGD:S000005907; FungiDB:YOR380W; VEuPathDB:YOR380W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription factor activity. Involved in response to xenobiotic stimulus. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RDR1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (1051290..1052930)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene alcohol O-acetyltransferase Neighboring gene Amf1p Neighboring gene ferric-chelate reductase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Zinc cluster protein Rdr1p is a transcriptional repressor of the PDR5 gene encoding a multidrug transporter. Hellauer K, et al. J Biol Chem, 2002 May 17. PMID 11882665
    2. Activation of the mitochondrial signaling pathway in response to organic solvent stress in yeast. Nishida-Aoki N, et al. Curr Genet, 2015 May. PMID 25487302
    3. Functional characterization and comparative analysis of gene repression-mediating domains interacting with yeast pleiotropic corepressors Sin3, Cyc8 and Tup1. Lettow J, et al. Curr Genet, 2023 Jun. PMID 36854981, Free PMC Article
    4. Extranuclear Structural Components that Mediate Dynamic Chromosome Movements in Yeast Meiosis. Lee CY, et al. Curr Biol, 2020 Apr 6. PMID 32059771, Free PMC Article
    5. Massively parallel measurements of molecular interaction kinetics on a microfluidic platform. Geertz M, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012409, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding HDA PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rdr1p
    NP_015025.3
    • Transcriptional repressor involved in regulating multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      1051290..1052930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183800.3 → NP_015025.3  TPA: Rdr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015025.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W372, Q08904
      UniProtKB/TrEMBL
      A6ZPK7, B3LK33, B5VSQ3, C7GVG7, C8ZHC7, G2WNN9, N1NZ17
      Conserved Domains (2) summary
      cd12148
      Location:158 → 334
      fungal_TF_MHR; fungal transcription factor regulatory middle homology region
      smart00066
      Location:14 → 50
      GAL4; GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08904.1

    Gene LinkOut

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