U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ACO1 aconitate hydratase ACO1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851013, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ACO1
    Official Full Name
    aconitate hydratase ACO1
    Primary source
    SGD:S000004295
    Locus tag
    YLR304C
    See related
    AllianceGenome:SGD:S000004295; FungiDB:YLR304C; VEuPathDB:YLR304C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GLU1
    Summary
    Enables aconitate hydratase activity and nucleic acid binding activity. Involved in mitochondrial genome maintenance and tricarboxylic acid cycle. Located in cytosol and mitochondrial nucleoid. Used to study central nervous system disease; neurodegenerative disease; optic atrophy 9; and optic nerve disease. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ACO1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (735212..737548, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 Neighboring gene tRNA-Ile Neighboring gene 1-phosphatidylinositol 4-kinase STT4 Neighboring gene NEDD8-conjugating protein UBC12

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning of the yeast mitochondrial aconitase gene (ACO1) and evidence of a synergistic regulation of expression by glucose plus glutamate. Gangloff SP, et al. Mol Cell Biol, 1990 Jul. PMID 1972545, Free PMC Article
    2. GroEL/GroES-mediated folding of a protein too large to be encapsulated. Chaudhuri TK, et al. Cell, 2001 Oct 19. PMID 11672530
    3. The aconitase C-terminal domain is an independent dual targeting element. Ben-Menachem R, et al. J Mol Biol, 2011 Jun 3. PMID 21440554
    4. Selective inhibition of the citrate-to-isocitrate reaction of cytosolic aconitase by phosphomimetic mutation of serine-711. Pitula JS, et al. Proc Natl Acad Sci U S A, 2004 Jul 27. PMID 15263083, Free PMC Article
    5. Quantitation of (a)symmetric inheritance of functional and of oxidatively damaged mitochondrial aconitase in the cell division of old yeast mother cells. Klinger H, et al. Exp Gerontol, 2010 Aug. PMID 20382214

    See all (151) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast ACO1 mitochondrial import is modulated by interactions of its C and N terminal domains and SSA1/SSA2.
      Title: Yeast aconitase mitochondrial import is modulated by interactions of its C and N terminal domains and Ssa1/2 (Hsp70).
    2. Lack of the ACO1 gene results in increased zinc tolerance.
      Title: On the molecular relationships between high-zinc tolerance and aconitase (Aco1) in Saccharomyces cerevisiae.
    3. mitochondria are opportunistic organelles that seize proteins, such as metabolic enzymes, for construction of the nucleoid, an mitochondrial DNA maintenance/segregation apparatus
      Title: Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA.
    4. essential for mtDNA maintenance independent of its catalytic activity; may integrate metabolic signals and mtDNA maintenance
      Title: Aconitase couples metabolic regulation to mitochondrial DNA maintenance.
    5. Yeast aconitase isoenzymes distribute between two distinct subcellular compartments and participate in two separate metabolic pathways: the glyoxylate shunt in the cytosol and the tricarboxylic acid cycle in mitochondria.
      Title: Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing.
    6. frataxin is an iron chaperone protein that protects the aconitase [4Fe-4S]2+ cluster from disassembly and promotes enzyme reactivation
      Title: Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aconitate hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aconitate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aconitate hydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial genome maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    aconitate hydratase ACO1
    NP_013407.1
    • Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; mutation in human homolog ACO2 is associated with dominant optic nerve atrophy; human homolog ACO2 can complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      735212..737548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182192.1 → NP_013407.1  TPA: aconitate hydratase ACO1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013407.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYU7, P19414
      UniProtKB/TrEMBL
      A7A1I8, B3RHI2, C7GUC7, C8ZDR7, G2WJC5, N1P1J9
      Conserved Domains (1) summary
      TIGR01340
      Location:41 → 772
      aconitase_mito; aconitate hydratase, mitochondrial
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19414.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.