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    RPS6A ribosomal 40S subunit protein S6A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856015, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RPS6A
    Official Full Name
    ribosomal 40S subunit protein S6A
    Primary source
    SGD:S000006011
    Locus tag
    YPL090C
    See related
    AllianceGenome:SGD:S000006011; FungiDB:YPL090C; VEuPathDB:YPL090C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    A structural constituent of ribosome. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Part of cytosolic small ribosomal subunit and small-subunit processome. Orthologous to human RPS6 (ribosomal protein S6). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RPS6A in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    2
    Sequence:
    Chromosome: XVI; NC_001148.4 (377291..378395, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Ssu1p Neighboring gene glutathione-disulfide reductase GLR1 Neighboring gene Rlm1p Neighboring gene aldo-keto reductase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast contains two functional genes coding for ribosomal protein S10. Leer RJ, et al. Nucleic Acids Res, 1985 Jul 25. PMID 2991849, Free PMC Article
    2. Evolutionary conservation of nuclear and nucleolar targeting sequences in yeast ribosomal protein S6A. Lipsius E, et al. Biochem Biophys Res Commun, 2005 Aug 12. PMID 15979583
    3. Functional interaction in establishment of ribosomal integrity between small subunit protein rpS6 and translational regulator rpL10/Grc5p. Pachler K, et al. FEMS Yeast Res, 2004 Dec. PMID 15556089
    4. Defects in Protein Folding Machinery Affect Cell Wall Integrity and Reduce Ethanol Tolerance in S. cerevisiae. Narayanan A, et al. Curr Microbiol, 2016 Jul. PMID 26992923
    5. Saccharomyces cerevisiae nutrient signaling pathways show an unexpected early activation pattern during winemaking. Vallejo B, et al. Microb Cell Fact, 2020 Jun 6. PMID 32505207, Free PMC Article

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribosomal 40S subunit protein S6A
    NP_015235.1
    • Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      377291..378395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183904.1 → NP_015235.1  TPA: ribosomal 40S subunit protein S6A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015235.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQH5, P02365, P05751, P0CX37, P0CX38, Q02894
      UniProtKB/TrEMBL
      A6ZLC2, C8ZIU0, D3UES5, G2W9I2, G2WP91
      Conserved Domains (1) summary
      cl00931
      Location:1 → 220
      Ribosomal_S6e; Ribosomal protein S6e
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CX37.1
    P0CX38.1

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