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    TPPP3 tubulin polymerization promoting protein family member 3 [ Homo sapiens (human) ]

    Gene ID: 51673, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TPPP3provided by HGNC
    Official Full Name
    tubulin polymerization promoting protein family member 3provided by HGNC
    Primary source
    HGNC:HGNC:24162
    See related
    Ensembl:ENSG00000159713 MIM:616957; AllianceGenome:HGNC:24162
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p20; CGI-38; TPPP/p20; p25gamma
    Summary
    Enables tubulin binding activity. Involved in decidualization and microtubule bundle formation. Located in microtubule bundle and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung (RPKM 89.8), placenta (RPKM 51.0) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TPPP3 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67389809..67393498, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73184580..73188269, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67423712..67427401, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7602 Neighboring gene RN7SK pseudogene 118 Neighboring gene leucine rich repeat containing 36 Neighboring gene RNA, U1 small nuclear 123, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67439721-67440606 Neighboring gene zinc finger DHHC-type containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67440607-67441493 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67441494-67442379 Neighboring gene uncharacterized LOC124903702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67450269-67450926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67454837-67455408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67458128-67458722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67461918-67462452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67462453-67462987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7605 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67469389-67469890 Neighboring gene hydroxysteroid 11-beta dehydrogenase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Modulatory Role of TPPP3 in Microtubule Organization and Its Impact on Alpha-Synuclein Pathology. Oláh J, et al. Cells, 2022 Sep 27. PMID 36230985, Free PMC Article
    2. The expression and role of tubulin polymerization-promoting protein 3 in oral squamous cell carcinoma. Xiao T, et al. Arch Oral Biol, 2022 Nov. PMID 36058091
    3. TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma. Yang Z, et al. Biomed Res Int, 2020. PMID 33083464, Free PMC Article
    4. Silence of TPPP3 suppresses cell proliferation, invasion and migration via inactivating NF-κB/COX2 signal pathway in breast cancer cell. Ren Q, et al. Cell Biochem Funct, 2020 Aug. PMID 32515139
    5. TPPP3 Promotes Cell Proliferation, Invasion and Tumor Metastasis via STAT3/ Twist1 Pathway in Non-Small-Cell Lung Carcinoma. Li Y, et al. Cell Physiol Biochem, 2018. PMID 30404076

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TPPP3 inhibits the proliferation, invasion and migration of endometrial carcinoma targeted with miR-1827.
      Title: TPPP3 inhibits the proliferation, invasion and migration of endometrial carcinoma targeted with miR-1827.
    2. TPPP3 promote epithelial-mesenchymal transition via Snail1 in glioblastoma.
      Title: TPPP3 promote epithelial-mesenchymal transition via Snail1 in glioblastoma.
    3. Modulatory Role of TPPP3 in Microtubule Organization and Its Impact on Alpha-Synuclein Pathology.
      Title: Modulatory Role of TPPP3 in Microtubule Organization and Its Impact on Alpha-Synuclein Pathology.
    4. The expression and role of tubulin polymerization-promoting protein 3 in oral squamous cell carcinoma.
      Title: The expression and role of tubulin polymerization-promoting protein 3 in oral squamous cell carcinoma.
    5. TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma.
      Title: TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma.
    6. Interaction of TPPP3 with VDAC1 Promotes Endothelial Injury through Activation of Reactive Oxygen Species.
      Title: Interaction of TPPP3 with VDAC1 Promotes Endothelial Injury through Activation of Reactive Oxygen Species.
    7. Silence of TPPP3 suppresses cell proliferation, invasion and migration via inactivating NF-kappaB/COX2 signal pathway in breast cancer cell.
      Title: Silence of TPPP3 suppresses cell proliferation, invasion and migration via inactivating NF-κB/COX2 signal pathway in breast cancer cell.
    8. Data suggest that tubulin polymerization-promoting protein family member 3 (TPPP3) plays a significant role in decidualization.
      Title: Inhibition of TPPP3 attenuates β-catenin/NF-κB/COX-2 signaling in endometrial stromal cells and impairs decidualization.
    9. TPPP3 overexpression enhanced cell proliferation, migration and invasion and regulated the expression of Twist1, suggesting that aberrant expression of TPPP3 could induce a more metastatic phenotype in non-small-cell lung carcinoma.
      Title: TPPP3 Promotes Cell Proliferation, Invasion and Tumor Metastasis via STAT3/ Twist1 Pathway in Non-Small-Cell Lung Carcinoma.
    10. TPPP3 played a crucial role in cell mitosis by regulating centrosomes amplification and/or spindles translocation processes.
      Title: Depletion of tubulin polymerization promoting protein family member 3 suppresses HeLa cell proliferation.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in decidualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo implantation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule bundle formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with microtubule bundle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tubulin polymerization-promoting protein family member 3
    Names
    brain specific protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015964.4 → NP_057048.2  tubulin polymerization-promoting protein family member 3

      See identical proteins and their annotated locations for NP_057048.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC000691, BQ640401
      Consensus CDS
      CCDS10835.1
      UniProtKB/Swiss-Prot
      Q49AH9, Q9BW30, Q9Y326, Q9Y6H0
      Related
      ENSP00000377529.2, ENST00000393957.7
      Conserved Domains (1) summary
      pfam05517
      Location:11 → 166
      p25-alpha; p25-alpha

    2. NM_016140.4 → NP_057224.2  tubulin polymerization-promoting protein family member 3

      See identical proteins and their annotated locations for NP_057224.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC000691, BI754230
      Consensus CDS
      CCDS10835.1
      UniProtKB/Swiss-Prot
      Q49AH9, Q9BW30, Q9Y326, Q9Y6H0
      Related
      ENSP00000290942.5, ENST00000290942.9
      Conserved Domains (1) summary
      pfam05517
      Location:11 → 166
      p25-alpha; p25-alpha

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67389809..67393498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450294.2 → XP_024306062.1  tubulin polymerization-promoting protein family member 3 isoform X1

      UniProtKB/Swiss-Prot
      Q49AH9, Q9BW30, Q9Y326, Q9Y6H0
      Related
      ENSP00000462435.1, ENST00000564104.5
      Conserved Domains (1) summary
      pfam05517
      Location:11 → 166
      p25-alpha; p25-alpha

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      73184580..73188269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BW30.1 GenPept UniProtKB/Swiss-Prot:Q9BW30

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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