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    PKR1 Pkr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855153, updated on 6-Oct-2024

    Summary

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    Official Symbol
    PKR1
    Official Full Name
    Pkr1p
    Primary source
    SGD:S000004730
    Locus tag
    YMR123W
    See related
    AllianceGenome:SGD:S000004730; FungiDB:YMR123W; VEuPathDB:YMR123W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in vacuolar proton-transporting V-type ATPase complex assembly. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PKR1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (513593..513961)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ncw1p Neighboring gene Epo1p Neighboring gene Sto1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PKR1 encodes an assembly factor for the yeast V-type ATPase. Davis-Kaplan SR, et al. J Biol Chem, 2006 Oct 20. PMID 16926153
    2. Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis. Piña FJ, et al. Eukaryot Cell, 2011 Jan. PMID 21097665, Free PMC Article
    3. Protein interaction networks by proteome peptide scanning. Landgraf C, et al. PLoS Biol, 2004 Jan. PMID 14737190, Free PMC Article
    4. Genome-scale genetic screen of lead ion-sensitive gene deletion mutations in Saccharomyces cerevisiae. Du J, et al. Gene, 2015 Jun 1. PMID 25773006
    5. Cdc1 removes the ethanolamine phosphate of the first mannose of GPI anchors and thereby facilitates the integration of GPI proteins into the yeast cell wall. Vazquez HM, et al. Mol Biol Cell, 2014 Nov 1. PMID 25165136, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pkr1p
    NP_013842.1
    • V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      513593..513961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182624.1 → NP_013842.1  TPA: Pkr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013842.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZU6, Q03880
      UniProtKB/TrEMBL
      A6ZMI3, C7GU95, C8ZEX8, N1NXD1
      Conserved Domains (1) summary
      pfam08636
      Location:4 → 73
      Pkr1; ER protein Pkr1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03880.1

    Gene LinkOut

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