Rhox5 Rhox homeobox family member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rhox5provided by RGD
Official Full Name: Rhox homeobox family member 5provided by RGD
Primary source: RGD:3295
See related: AllianceGenome:RGD:3295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pem
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 4.7), Liver (RPKM 3.9) and 6 other tissues See more
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Genomic context

Location:: Xq35

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (121401888..121407643)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (116536207..116541972)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (123900357..123916988)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

regulates the expression of other Rhox genes in the epididymis
Title: The Rhox5 homeobox gene regulates the region-specific expression of its paralogs in the rodent epididymis.
GATA factors collaborate to dictate the unique developmental and region-specific expression pattern of the RHOX5 homeobox transcription factor in the caput epididymis.
Title: DNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis.
Pem promoter may be a useful model system to understand the molecular mechanism by which a tissue-specific promoter can be corrupted in tumor cells
Title: A highly active homeobox gene promoter regulated by Ets and Sp1 family members in normal granulosa cells and diverse tumor cell types.
expression in the ovary is governed by the distal promoter and is expressed at least as early as Day 5 postpartum. mRNA levels are regulated during the ovarian cycle, peaking before ovulation
Title: Regulation of the Rhox5 homeobox gene in primary granulosa cells: preovulatory expression and dependence on SP1/SP3 and GABP.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142214 (e-PCR)
- UniSTS:231464

DXWox35 (e-PCR)
- UniSTS:240185

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein Rhox5

Names: Homeobox gene Pem; homeobox protein Pem; placenta and embryonic expression protein; placentae and embryos oncofetal; reproductive homeobox 5; reproductive homeobox on chromosome X 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022175.2 → NP_071511.2 homeobox protein Rhox5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0U1RS42, A6JMI5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

121401888..121407643

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279791.1 → XP_063135861.1 homeobox protein Rhox5 isoform X2

UniProtKB/TrEMBL

A0A0U1RS42
XM_039099480.2 → XP_038955408.1 homeobox protein Rhox5 isoform X2

UniProtKB/TrEMBL

A0A0U1RS42, A6JMI5
XM_039099477.2 → XP_038955405.1 homeobox protein Rhox5 isoform X1

UniProtKB/TrEMBL

A6JMI5
XM_039099476.2 → XP_038955404.1 homeobox protein Rhox5 isoform X1

UniProtKB/TrEMBL

A6JMI5
XM_039099479.2 → XP_038955407.1 homeobox protein Rhox5 isoform X2

UniProtKB/TrEMBL

A0A0U1RS42, A6JMI5