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    St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25197, updated on 17-Aug-2024

    Summary

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    Official Symbol
    St6gal1provided by RGD
    Official Full Name
    ST6 beta-galactoside alpha-2,6-sialyltransferase 1provided by RGD
    Primary source
    RGD:3676
    See related
    EnsemblRapid:ENSRNOG00000001823 AllianceGenome:RGD:3676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Siat1
    Summary
    Enables sialyltransferase activity. Involved in several processes, including negative regulation of macrophage apoptotic process; protein sialylation; and regulation of substrate adhesion-dependent cell spreading. Located in Golgi medial cisterna; Golgi trans cisterna; and endoplasmic reticulum. Used to study high grade glioma. Orthologous to human ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 1020.2), Kidney (RPKM 382.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    11q23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (91031481..91158111, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (77526837..77653474, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (80927601..80981424, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene microtubule associated serine/threonine kinase 2, pseudogene 1 Neighboring gene uncharacterized LOC120095690 Neighboring gene ST6 beta-galactoside alpha-2,6-sialyltransferase 1 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enzymatic basis for N-glycan sialylation: structure of rat α2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation. Meng L, et al. J Biol Chem, 2013 Nov 29. PMID 24155237, Free PMC Article
    2. Development of sandwich enzyme-linked immunosorbent assay systems for plasma beta-galactoside alpha2,6-sialyltransferase, a possible hepatic disease biomarker. Futakawa S, et al. Anal Chim Acta, 2009 Jan 5. PMID 19046688
    3. The two rat alpha 2,6-sialyltransferase (ST6Gal I) isoforms: evaluation of catalytic activity and intra-Golgi localization. Chen TL, et al. Glycobiology, 2003 Feb. PMID 12626411
    4. Alpha2,6-sialylation of cell-surface N-glycans inhibits glioma formation in vivo. Yamamoto H, et al. Cancer Res, 2001 Sep 15. PMID 11559557
    5. Mammalian glycosyltransferase expression allows sialoglycoprotein production by baculovirus-infected insect cells. Seo NS, et al. Protein Expr Purif, 2001 Jul. PMID 11437599

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparisons of the structure with pig ST3GAL1 and a bacterial sialyltransferase revealed a similar positioning of donor, acceptor, and catalytic residues that provide a common structural framework for catalysis
      Title: Enzymatic basis for N-glycan sialylation: structure of rat α2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation.
    2. ST6Gal-I regulates macrophage apoptosis via alpha2-6 sialylation of the TNFR1 death receptor.
      Title: ST6Gal-I regulates macrophage apoptosis via α2-6 sialylation of the TNFR1 death receptor.
    3. rat ST6GAL1 mRNA possess an L exon, suggesting conservation of this regulatory element in rodents
      Title: Conservation of the ST6Gal I gene and its expression in the mammary gland.
    4. There are two possible mechanisms for the upregulation of plasma ST6Gal I in hepatopathological situations: one accompanied by acute phase reactions to increase hepatic ST6Gal I expression and the other triggered by oxidative stress in the liver.
      Title: Molecular insights into beta-galactoside alpha2,6-sialyltransferase secretion in vivo.
    5. soluble ST6Gal I produced by BACE1 plays, at least in part, a role in the sialylation of soluble glycoproteins
      Title: Beta-galactoside alpha2,6-sialyltransferase I cleavage by BACE1 enhances the sialylation of soluble glycoproteins. A novel regulatory mechanism for alpha2,6-sialylation.
    6. Results suggest that ST6Gal I is cleaved initially between Leu(37) and Gln(38) by BACE1, and then the three-amino acid sequence at the NH(2) terminus is removed by exopeptidase(s) before secretion from the cells.
      Title: Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).
    7. BACE1 cleaves ST6Gal I in vivo and controls the secretion of the E41 form of the ST6Gal I protein
      Title: In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase.
    8. The addition of rat alpha 2,6-sialyltransferase in a metabolically engineered baculovirus-infected insect cell system enables successful production of sialylated glycoprotein.
      Title: Mammalian glycosyltransferase expression allows sialoglycoprotein production by baculovirus-infected insect cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-galactoside alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactoside alpha-2,6-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-galactoside alpha-2,6-sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylneuraminate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-acetylneuraminate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of macrophage apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of mononuclear cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sialylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sialylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sialylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi medial cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi trans cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-galactoside alpha-2,6-sialyltransferase 1
    Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1
    ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
    ST6Gal I
    ST6GalI
    Sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase)
    Sialyltransferase 1 (beta-galactoside alpha-26-sialytransferase)
    alpha 2,6-ST 1
    NP_001106815.1
    NP_671738.2
    XP_006248563.1
    XP_038943921.1
    XP_038943922.1
    XP_038943923.1
    XP_038943924.1
    XP_038943925.1
    XP_063126365.1
    XP_063126366.1
    XP_063126367.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113344.1 → NP_001106815.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_001106815.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000011, M18769
      UniProtKB/Swiss-Prot
      D4ABR2, G3V680, P13721
      Conserved Domains (1) summary
      pfam00777
      Location:166 → 379
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_147205.2 → NP_671738.2  beta-galactoside alpha-2,6-sialyltransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_671738.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      BF418553, JAXUCZ010000011, M83143
      UniProtKB/TrEMBL
      F2Z3S3
      Related
      ENSRNOP00000002496.7, ENSRNOT00000002496.9
      Conserved Domains (1) summary
      pfam00777
      Location:63 → 190
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      91031481..91158111 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087995.2 → XP_038943923.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      D4ABR2, G3V680, P13721
      Conserved Domains (1) summary
      pfam00777
      Location:166 → 379
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_063270296.1 → XP_063126366.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      D4ABR2, G3V680, P13721

    3. XM_039087993.2 → XP_038943921.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      D4ABR2, G3V680, P13721
      Conserved Domains (1) summary
      pfam00777
      Location:166 → 379
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. XM_006248501.3 → XP_006248563.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006248563.1

      UniProtKB/Swiss-Prot
      D4ABR2, G3V680, P13721
      Conserved Domains (1) summary
      pfam00777
      Location:166 → 379
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. XM_039087996.2 → XP_038943924.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      D4ABR2, G3V680, P13721
      Conserved Domains (1) summary
      pfam00777
      Location:166 → 379
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    6. XM_039087994.2 → XP_038943922.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      D4ABR2, G3V680, P13721
      Conserved Domains (1) summary
      pfam00777
      Location:166 → 379
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    7. XM_063270295.1 → XP_063126365.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      D4ABR2, G3V680, P13721

    8. XM_063270297.1 → XP_063126367.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      D4ABR2, G3V680, P13721

    9. XM_039087997.2 → XP_038943925.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      D4ABR2, G3V680, P13721
      Conserved Domains (1) summary
      pfam00777
      Location:166 → 379
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13721.2 GenPept UniProtKB/Swiss-Prot:P13721

    Gene LinkOut

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