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    Cenpt centromere protein T [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307805, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Cenptprovided by RGD
    Official Full Name
    centromere protein Tprovided by RGD
    Primary source
    RGD:1309383
    See related
    EnsemblRapid:ENSRNOG00000024178 AllianceGenome:RGD:1309383
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309383
    Summary
    Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be involved in chromosome segregation; kinetochore assembly; and mitotic cell cycle. Predicted to be located in kinetochore and nuclear body. Orthologous to human CENPT (centromere protein T). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 97.0), Spleen (RPKM 73.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    19q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50644548..50651048, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33734684..33741159, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37813284..37819782, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene Gfo/Idh/MocA-like oxidoreductase domain containing 2 Neighboring gene uncharacterized LOC134483349 Neighboring gene RAN binding protein 10 Neighboring gene uncharacterized LOC108348930 Neighboring gene translin-associated factor X interacting protein 1 Neighboring gene THAP domain containing 11 Neighboring gene nuclear transport factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state. Prendergast L, et al. PLoS Biol, 2011 Jun. PMID 21695110, Free PMC Article
    2. Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes. Gascoigne KE, et al. Cell, 2011 Apr 29. PMID 21529714, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112755

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in kinetochore assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kinetochore assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kinetochore assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centromere protein T
    Names
    CENP-T

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024257.1 → NP_001019428.1  centromere protein T

      See identical proteins and their annotated locations for NP_001019428.1

      Status: PROVISIONAL

      Source sequence(s)
      BC093396
      UniProtKB/Swiss-Prot
      Q561R1
      UniProtKB/TrEMBL
      A0A8I6GKT8
      Related
      ENSRNOP00000029297.3, ENSRNOT00000036702.6
      Conserved Domains (2) summary
      pfam15511
      Location:407 → 510
      CENP-T_C; Centromere kinetochore component CENP-T histone fold
      pfam16171
      Location:1 → 375
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50644548..50651048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278032.1 → XP_063134102.1  centromere protein T isoform X5

      UniProtKB/TrEMBL
      A6IYS7

    2. XM_063278030.1 → XP_063134100.1  centromere protein T isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKT8

    3. XM_039097738.2 → XP_038953666.1  centromere protein T isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKT8
      Conserved Domains (2) summary
      pfam15511
      Location:483 → 586
      CENP-T_C; Centromere kinetochore component CENP-T histone fold
      pfam16171
      Location:1 → 375
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus

    4. XM_063278031.1 → XP_063134101.1  centromere protein T isoform X3

      UniProtKB/TrEMBL
      A0A8I6GKT8

    5. XM_039097740.2 → XP_038953668.1  centromere protein T isoform X4

      Conserved Domains (2) summary
      pfam15511
      Location:379 → 482
      CENP-T_C; Centromere kinetochore component CENP-T histone fold
      pfam16171
      Location:1 → 271
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus

    6. XM_039097739.2 → XP_038953667.1  centromere protein T isoform X4

      Conserved Domains (2) summary
      pfam15511
      Location:379 → 482
      CENP-T_C; Centromere kinetochore component CENP-T histone fold
      pfam16171
      Location:1 → 271
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus

    7. XM_063278033.1 → XP_063134103.1  centromere protein T isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q561R1.1 GenPept UniProtKB/Swiss-Prot:Q561R1

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