Dolpp1 dolichyldiphosphatase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dolpp1provided by RGD
Official Full Name: dolichyldiphosphatase 1provided by RGD
Primary source: RGD:1307447
See related: EnsemblRapid:ENSRNOG00000017663 AllianceGenome:RGD:1307447
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable dolichyldiphosphatase activity. Predicted to be involved in lipid biosynthetic process and protein N-linked glycosylation. Predicted to be active in intracellular membrane-bounded organelle. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human DOLPP1 (dolichyldiphosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 33.9), Kidney (RPKM 29.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (34063825..34072133)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (13666000..13674312)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (8957103..8966618)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134378 (e-PCR)
- UniSTS:217660

REN36342 (e-PCR)
- UniSTS:361142

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dolichyldiphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyldiphosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dolichyldiphosphatase 1

Names: dolichyl pyrophosphate phosphatase 1

NP_001100037.1

EC 3.6.1.43

NP_001386275.1

EC 3.6.1.43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106567.3 → NP_001100037.1 dolichyldiphosphatase 1 isoform 2

See identical proteins and their annotated locations for NP_001100037.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6JTY4, A6JTY5, D3Z917

Related

ENSRNOP00000058902.1, ENSRNOT00000064557.3

Conserved Domains (1) summary

cd03382
Location:16 → 154

PAP2_dolichyldiphosphatase; PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is ...
NM_001399346.2 → NP_001386275.1 dolichyldiphosphatase 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2JUS5, A6JTY3

Related

ENSRNOP00000069211.3, ENSRNOT00000086789.3

Conserved Domains (1) summary

cd03382
Location:16 → 180

PAP2_dolichyldiphosphatase; PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is ...