Abhd2 abhydrolase domain containing 2, acylglycerol lipase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abhd2provided by RGD
Official Full Name: abhydrolase domain containing 2, acylglycerol lipaseprovided by RGD
Primary source: RGD:1311389
See related: EnsemblRapid:ENSRNOG00000017120 AllianceGenome:RGD:1311389
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable carboxylic ester hydrolase activity; hormone binding activity; and steroid hormone receptor activity. Predicted to be involved in several processes, including medium-chain fatty acid metabolic process; response to steroid hormone; and sperm capacitation. Predicted to act upstream of or within negative regulation of cell migration and response to wounding. Predicted to be located in acrosomal vesicle. Predicted to be active in sperm flagellum and sperm plasma membrane. Orthologous to human ABHD2 (abhydrolase domain containing 2, acylglycerol lipase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 1461.8), Liver (RPKM 1365.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (142626748..142707892)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (133217403..133298564)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (140998240..141087405)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

BF413329 (e-PCR)
- UniSTS:248539

Abhd2 (e-PCR), detects polymorphism
- UniSTS:265209

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylesterase activity	ISO Inferred from Sequence Orthology more info
enables diacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables monoacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables nuclear steroid receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acrosome reaction	ISO Inferred from Sequence Orthology more info
involved_in acylglycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in medium-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in medium-chain fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in response to progesterone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info
acts_upstream_of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm capacitation	ISO Inferred from Sequence Orthology more info
involved_in steroid hormone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
is_active_in sperm flagellum	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
is_active_in sperm plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: monoacylglycerol lipase ABHD2

Names: abhydrolase domain-containing protein 2

NP_001099745.1

EC 3.1.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.