F3 coagulation factor III [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: F3provided by MGI
Official Full Name: coagulation factor IIIprovided by MGI
Primary source: MGI:MGI:88381
See related: Ensembl:ENSMUSG00000028128 AllianceGenome:MGI:88381
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TF; Cf3; Cf-3; CD142
Summary: This gene encodes a membrane-bound glycoprotein that forms the primary physiological initiator of the blood coagulation process following vascular damage. The encoded protein binds to coagulation factor VIIa and the ensuing complex catalyzes the proteolytic activation of coagulation factors IX and X. Mice lacking encoded protein die in utero resulting from massive hemorrhaging in both extraembryonic and embryonic vessels. A severe deficiency of the encoded protein in mice results in impaired uterine homeostasis, shorter life spans due to spontaneous fatal hemorrhages and cardiac fibrosis. [provided by RefSeq, Aug 2015]
Expression: Broad expression in bladder adult (RPKM 29.5), subcutaneous fat pad adult (RPKM 20.6) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G1; 3 52.94 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (121517186..121528701)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (121723537..121735052)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Direct contact between tumor cells and platelets initiates a FAK-dependent F3/TGF-beta positive feedback loop that promotes tumor progression and EMT in osteosarcoma.
Title: Direct contact between tumor cells and platelets initiates a FAK-dependent F3/TGF-β positive feedback loop that promotes tumor progression and EMT in osteosarcoma.
CD142 promotes trophoblast cell migration by inhibiting BCL2-related autophagic degradation of IL-8.
Title: CD142 promotes trophoblast cell migration by inhibiting BCL2-related autophagic degradation of IL-8.
The Intrinsic Pathway does not Contribute to Activation of Coagulation in Mice Bearing Human Pancreatic Tumors Expressing Tissue Factor.
Title: The Intrinsic Pathway does not Contribute to Activation of Coagulation in Mice Bearing Human Pancreatic Tumors Expressing Tissue Factor.
Cardiac Tissue Factor Regulates Inflammation, Hypertrophy, and Heart Failure in Mouse Model of Type 1 Diabetes.
Title: Cardiac Tissue Factor Regulates Inflammation, Hypertrophy, and Heart Failure in Mouse Model of Type 1 Diabetes.
Hypoxia induced up-regulation of tissue factor is mediated through extracellular RNA activated Toll-like receptor 3-activated protein 1 signalling.
Title: Hypoxia induced up-regulation of tissue factor is mediated through extracellular RNA activated Toll-like receptor 3-activated protein 1 signalling.
These data indicate that lipopolysaccharide - or cytokine-induced TF procoagulant activity requires the decryption of newly synthesized TF protein by ASMase-mediated hydrolysis of sphingomyelin.
Title: Acid sphingomyelinase plays a critical role in LPS- and cytokine-induced tissue factor procoagulant activity.
The expression of tissue factor was increased in the artery of Klf11 knockout mice. Vascular smooth muscle cells isolated from Klf11 knockout mouse aortas showed increased tissue factor expression, which was rescued by KLF11 overexpression.
Title: KLF11 (Krüppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall.
TF overexpression enhanced plaque thrombogenicity, which played a pivotal role in atherothrombosis in ApoE-/- mice.
Title: Overexpression of tissue factor induced atherothrombosis in apolipoprotein E-/- mice via both enhanced plaque thrombogenicity and plaque instability.
Sirt3 loss-of-function enhances experimental thrombosis in vivo via an increase of neutrophil extracellular traps and elevation of TF suggesting thrombo-protective effects of endogenous Sirt3.
Title: Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.
Androgen receptor is crucial for dampening prostate tissue factor expression via nuclear factor-kappaB and early growth response protein 1 pathway.
Title: Androgen receptor dampens tissue factor expression via nuclear factor-κB and early growth response protein 1.

Submit: New GeneRIF Correction See all GeneRIFs (120)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (9) 1 citation

General gene information

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Markers

F3 (e-PCR), detects polymorphism
- UniSTS:525907

RH124818 (e-PCR)
- UniSTS:161640

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
contributes_to serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in activation of plasma proteins involved in acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood coagulation	TAS Traceable Author Statement more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of serine-type peptidase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tissue factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.